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- W4385880069 abstract "Aging is the key risk factor for cognitive decline, yet the molecular changes underlying brain aging remain poorly understood. Here, we conducted spatiotemporal RNA sequencing of the mouse brain, profiling 1,076 samples from 15 regions across 7 ages and 2 rejuvenation interventions. Our analysis identified a brain-wide gene signature of aging in glial cells, which exhibited spatially defined changes in magnitude. By integrating spatial and single-nucleus transcriptomics, we found that glial aging was particularly accelerated in white matter compared with cortical regions, whereas specialized neuronal populations showed region-specific expression changes. Rejuvenation interventions, including young plasma injection and dietary restriction, exhibited distinct effects on gene expression in specific brain regions. Furthermore, we discovered differential gene expression patterns associated with three human neurodegenerative diseases, highlighting the importance of regional aging as a potential modulator of disease. Our findings identify molecular foci of brain aging, providing a foundation to target age-related cognitive decline." @default.
- W4385880069 created "2023-08-17" @default.
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- W4385880069 date "2023-09-01" @default.
- W4385880069 modified "2023-10-18" @default.
- W4385880069 title "Atlas of the aging mouse brain reveals white matter as vulnerable foci" @default.
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- W4385880069 cites W1696199194 @default.
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- W4385880069 cites W1966327575 @default.
- W4385880069 cites W1969352576 @default.
- W4385880069 cites W1969455604 @default.
- W4385880069 cites W1969905245 @default.
- W4385880069 cites W1978927200 @default.
- W4385880069 cites W1979283544 @default.
- W4385880069 cites W1983729920 @default.
- W4385880069 cites W2008352401 @default.
- W4385880069 cites W2019552331 @default.
- W4385880069 cites W2022689242 @default.
- W4385880069 cites W2042663107 @default.
- W4385880069 cites W2055343818 @default.
- W4385880069 cites W2066399252 @default.
- W4385880069 cites W2069049877 @default.
- W4385880069 cites W2100239923 @default.
- W4385880069 cites W2110129932 @default.
- W4385880069 cites W2113214449 @default.
- W4385880069 cites W2114926230 @default.
- W4385880069 cites W2117593197 @default.
- W4385880069 cites W2117970703 @default.
- W4385880069 cites W2123491442 @default.
- W4385880069 cites W2126525177 @default.
- W4385880069 cites W2146512944 @default.
- W4385880069 cites W2179438025 @default.
- W4385880069 cites W2190545194 @default.
- W4385880069 cites W2191292005 @default.
- W4385880069 cites W2213269341 @default.
- W4385880069 cites W2255138985 @default.
- W4385880069 cites W2261364877 @default.
- W4385880069 cites W2345745180 @default.
- W4385880069 cites W2345969280 @default.
- W4385880069 cites W2346448457 @default.
- W4385880069 cites W2401987785 @default.
- W4385880069 cites W2552939764 @default.
- W4385880069 cites W2568020671 @default.
- W4385880069 cites W2605569345 @default.
- W4385880069 cites W2724299234 @default.
- W4385880069 cites W2725775500 @default.
- W4385880069 cites W2782274120 @default.
- W4385880069 cites W2790139801 @default.
- W4385880069 cites W2809368942 @default.
- W4385880069 cites W2889294609 @default.
- W4385880069 cites W2900678737 @default.
- W4385880069 cites W2901550516 @default.
- W4385880069 cites W2934339908 @default.
- W4385880069 cites W2942678593 @default.
- W4385880069 cites W2949177718 @default.
- W4385880069 cites W2954434934 @default.
- W4385880069 cites W2972368830 @default.
- W4385880069 cites W2975507539 @default.
- W4385880069 cites W2976681669 @default.
- W4385880069 cites W2980437065 @default.
- W4385880069 cites W2993515580 @default.
- W4385880069 cites W2998795963 @default.
- W4385880069 cites W3005127469 @default.
- W4385880069 cites W3010042062 @default.
- W4385880069 cites W3020099929 @default.
- W4385880069 cites W3039975419 @default.
- W4385880069 cites W3042406747 @default.
- W4385880069 cites W3044030235 @default.
- W4385880069 cites W3045501231 @default.
- W4385880069 cites W3106879684 @default.
- W4385880069 cites W3109025853 @default.
- W4385880069 cites W3120608220 @default.
- W4385880069 cites W3127249947 @default.
- W4385880069 cites W3132186274 @default.
- W4385880069 cites W3134111171 @default.
- W4385880069 cites W3135398361 @default.
- W4385880069 cites W3175961346 @default.
- W4385880069 cites W3179857518 @default.
- W4385880069 cites W3184248450 @default.