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• W4385890351 abstract "De novo assembly is the process of reconstructing the genome sequence of an organism from sequencing reads. Genome sequences are essential to biology, and assembly has been a central problem in bioinformatics for four decades. Until recently, genomes were typically assembled into fragments of a few megabases at best but technological advances in long-read sequencing now enable near complete chromosome-level assembly, also known as telomere-to-telomere assembly, for many organisms. Here we review recent progress on assembly algorithms and protocols. We focus on how to derive near telomere-to-telomere assemblies and discuss potential future developments." @default.
• W4385890351 created "2023-08-17" @default.
• W4385890351 creator A5013795174 @default.
• W4385890351 creator A5082040351 @default.
• W4385890351 date "2023-08-15" @default.
• W4385890351 modified "2023-09-27" @default.
• W4385890351 title "Genome assembly in the telomere-to-telomere era." @default.
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• W4385890351 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37645045" @default.
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