Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385904823> ?p ?o ?g. }
- W4385904823 abstract "Abstract The immune-cell origin of hematologic malignancies provides a unique avenue for the understanding of both the mechanisms of immune responsiveness and immune escape, which has accelerated the progress of immunotherapy. Several categories of immunotherapies have been developed and are being further evaluated in clinical trials for the treatment of blood cancers, including stem cell transplantation, immune checkpoint inhibitors, antigen-targeted antibodies, antibody-drug conjugates, tumor vaccines, and adoptive cell therapies. These immunotherapies have shown the potential to induce long-term remission in refractory or relapsed patients and have led to a paradigm shift in cancer treatment with great clinical success. Different immunotherapeutic approaches have their advantages but also shortcomings that need to be addressed. To provide clinicians with timely information on these revolutionary therapeutic approaches, the comprehensive review provides historical perspectives on the applications and clinical considerations of the immunotherapy. Here, we first outline the recent advances that have been made in the understanding of the various categories of immunotherapies in the treatment of hematologic malignancies. We further discuss the specific mechanisms of action, summarize the clinical trials and outcomes of immunotherapies in hematologic malignancies, as well as the adverse effects and toxicity management and then provide novel insights into challenges and future directions." @default.
- W4385904823 created "2023-08-18" @default.
- W4385904823 creator A5021628223 @default.
- W4385904823 creator A5027244110 @default.
- W4385904823 creator A5048815633 @default.
- W4385904823 creator A5074069807 @default.
- W4385904823 date "2023-08-18" @default.
- W4385904823 modified "2023-10-16" @default.
- W4385904823 title "Immunotherapy in hematologic malignancies: achievements, challenges and future prospects" @default.
- W4385904823 cites W1483682701 @default.
- W4385904823 cites W1501039723 @default.
- W4385904823 cites W1547137083 @default.
- W4385904823 cites W1585625390 @default.
- W4385904823 cites W1594509286 @default.
- W4385904823 cites W1600940429 @default.
- W4385904823 cites W1604141497 @default.
- W4385904823 cites W161140084 @default.
- W4385904823 cites W1763981524 @default.
- W4385904823 cites W1826925790 @default.
- W4385904823 cites W1842764967 @default.
- W4385904823 cites W1848664898 @default.
- W4385904823 cites W1880801097 @default.
- W4385904823 cites W1902692042 @default.
- W4385904823 cites W1915689252 @default.
- W4385904823 cites W1938515409 @default.
- W4385904823 cites W1939946230 @default.
- W4385904823 cites W1942897646 @default.
- W4385904823 cites W1943878720 @default.
- W4385904823 cites W1945251789 @default.
- W4385904823 cites W1967512987 @default.
- W4385904823 cites W1970942128 @default.
- W4385904823 cites W1973171445 @default.
- W4385904823 cites W1978032636 @default.
- W4385904823 cites W1982952278 @default.
- W4385904823 cites W1984614343 @default.
- W4385904823 cites W1986354050 @default.
- W4385904823 cites W1986741896 @default.
- W4385904823 cites W1990789777 @default.
- W4385904823 cites W1991644988 @default.
- W4385904823 cites W1992343552 @default.
- W4385904823 cites W1994301526 @default.
- W4385904823 cites W1994336777 @default.
- W4385904823 cites W1994993231 @default.
- W4385904823 cites W1995090169 @default.
- W4385904823 cites W1996815863 @default.
- W4385904823 cites W2003089766 @default.
- W4385904823 cites W2004037261 @default.
- W4385904823 cites W2004265862 @default.
- W4385904823 cites W2005984068 @default.
- W4385904823 cites W2010175068 @default.
- W4385904823 cites W2013711068 @default.
- W4385904823 cites W2015451788 @default.
- W4385904823 cites W2016789384 @default.
- W4385904823 cites W2016973656 @default.
- W4385904823 cites W2017874886 @default.
- W4385904823 cites W2018295245 @default.
- W4385904823 cites W2019214729 @default.
- W4385904823 cites W2019789998 @default.
- W4385904823 cites W2021009347 @default.
- W4385904823 cites W2021588881 @default.
- W4385904823 cites W2022772870 @default.
- W4385904823 cites W2022996006 @default.
- W4385904823 cites W2023431277 @default.
- W4385904823 cites W2025338891 @default.
- W4385904823 cites W2031452426 @default.
- W4385904823 cites W2036387778 @default.
- W4385904823 cites W2039334806 @default.
- W4385904823 cites W2039715386 @default.
- W4385904823 cites W2047205338 @default.
- W4385904823 cites W2048773859 @default.
- W4385904823 cites W2049459265 @default.
- W4385904823 cites W2050115670 @default.
- W4385904823 cites W2051944033 @default.
- W4385904823 cites W2056662191 @default.
- W4385904823 cites W2057463153 @default.
- W4385904823 cites W2057968168 @default.
- W4385904823 cites W2059995755 @default.
- W4385904823 cites W2062889582 @default.
- W4385904823 cites W2063192133 @default.
- W4385904823 cites W2064610182 @default.
- W4385904823 cites W2065239231 @default.
- W4385904823 cites W2065528643 @default.
- W4385904823 cites W2066671159 @default.
- W4385904823 cites W2067948267 @default.
- W4385904823 cites W2068302119 @default.
- W4385904823 cites W2068646465 @default.
- W4385904823 cites W2070360032 @default.
- W4385904823 cites W2075902150 @default.
- W4385904823 cites W2080742973 @default.
- W4385904823 cites W2082708772 @default.
- W4385904823 cites W2082802388 @default.
- W4385904823 cites W2083691419 @default.
- W4385904823 cites W2084659308 @default.
- W4385904823 cites W2086693026 @default.
- W4385904823 cites W2087857484 @default.
- W4385904823 cites W2089717366 @default.
- W4385904823 cites W2090739823 @default.
- W4385904823 cites W2091057822 @default.
- W4385904823 cites W2093263100 @default.
- W4385904823 cites W2093871508 @default.