Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385907185> ?p ?o ?g. }
- W4385907185 abstract "Abstract Circulatory shock is defined syndromically as hypotension associated with tissue hypoperfusion and often subcategorized according to hemodynamic profile (e.g., distributive, cardiogenic, hypovolemic) and etiology (e.g., infection, myocardial infarction, trauma, among others). These shock subgroups are generally considered homogeneous entities in research and clinical practice. This current definition fails to consider the complex pathophysiology of shock and the influence of patient heterogeneity. Recent translational evidence highlights previously under-appreciated heterogeneity regarding the underlying pathways with distinct host-response patterns in circulatory shock syndromes. This heterogeneity may confound the interpretation of trial results as a given treatment may preferentially impact distinct subgroups. Re-analyzing results of major ‘neutral’ treatment trials from the perspective of biological mechanisms (i.e., host-response signatures) may reveal treatment effects in subgroups of patients that share treatable traits (i.e., specific biological signatures that portend a predictable response to a given treatment). In this review, we discuss the emerging literature suggesting the existence of distinct biomarker-based host-response patterns of circulatory shock syndrome independent of etiology or hemodynamic profile. We further review responses to newly prescribed treatments in the intensive care unit designed to personalize treatments (biomarker-driven or endotype-driven patient selection in support of future clinical trials)." @default.
- W4385907185 created "2023-08-18" @default.
- W4385907185 creator A5001192465 @default.
- W4385907185 creator A5010513524 @default.
- W4385907185 creator A5013249076 @default.
- W4385907185 creator A5026254558 @default.
- W4385907185 creator A5034441524 @default.
- W4385907185 creator A5057636738 @default.
- W4385907185 creator A5063880800 @default.
- W4385907185 creator A5069514943 @default.
- W4385907185 creator A5070604004 @default.
- W4385907185 creator A5091313128 @default.
- W4385907185 date "2023-08-18" @default.
- W4385907185 modified "2023-10-17" @default.
- W4385907185 title "Distinct host-response signatures in circulatory shock: a narrative review" @default.
- W4385907185 cites W1924238075 @default.
- W4385907185 cites W1991209345 @default.
- W4385907185 cites W2057979643 @default.
- W4385907185 cites W2067090053 @default.
- W4385907185 cites W2071057542 @default.
- W4385907185 cites W2095944485 @default.
- W4385907185 cites W2097364950 @default.
- W4385907185 cites W2103727400 @default.
- W4385907185 cites W2104825124 @default.
- W4385907185 cites W2106543129 @default.
- W4385907185 cites W2155331090 @default.
- W4385907185 cites W2177407033 @default.
- W4385907185 cites W2274346642 @default.
- W4385907185 cites W2499637665 @default.
- W4385907185 cites W2540963844 @default.
- W4385907185 cites W2561288668 @default.
- W4385907185 cites W2581605534 @default.
- W4385907185 cites W2586773298 @default.
- W4385907185 cites W2614578436 @default.
- W4385907185 cites W2789446953 @default.
- W4385907185 cites W2883340375 @default.
- W4385907185 cites W2886027918 @default.
- W4385907185 cites W2897735762 @default.
- W4385907185 cites W2898483928 @default.
- W4385907185 cites W2901255373 @default.
- W4385907185 cites W2906288826 @default.
- W4385907185 cites W2944988359 @default.
- W4385907185 cites W2974323409 @default.
- W4385907185 cites W2977895282 @default.
- W4385907185 cites W2994813104 @default.
- W4385907185 cites W3008165957 @default.
- W4385907185 cites W3033281129 @default.
- W4385907185 cites W3035338615 @default.
- W4385907185 cites W3037477403 @default.
- W4385907185 cites W3040546271 @default.
- W4385907185 cites W3101169228 @default.
- W4385907185 cites W3102707424 @default.
- W4385907185 cites W3118836301 @default.
- W4385907185 cites W3154178180 @default.
- W4385907185 cites W3178881950 @default.
- W4385907185 cites W3180782340 @default.
- W4385907185 cites W3192489984 @default.
- W4385907185 cites W3199546171 @default.
- W4385907185 cites W3203725826 @default.
- W4385907185 cites W4200071867 @default.
- W4385907185 cites W4200090846 @default.
- W4385907185 cites W4210564798 @default.
- W4385907185 cites W4210713587 @default.
- W4385907185 cites W4210941072 @default.
- W4385907185 cites W4214635346 @default.
- W4385907185 cites W4224222931 @default.
- W4385907185 cites W4225295092 @default.
- W4385907185 cites W4229453761 @default.
- W4385907185 cites W4253371818 @default.
- W4385907185 cites W4254170669 @default.
- W4385907185 cites W4283022274 @default.
- W4385907185 cites W4283319043 @default.
- W4385907185 cites W4307190334 @default.
- W4385907185 cites W4308489971 @default.
- W4385907185 cites W4310524002 @default.
- W4385907185 cites W4310778978 @default.
- W4385907185 cites W4310784069 @default.
- W4385907185 cites W4311724243 @default.
- W4385907185 cites W4317038776 @default.
- W4385907185 doi "https://doi.org/10.1186/s40635-023-00531-5" @default.
- W4385907185 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37592121" @default.
- W4385907185 hasPublicationYear "2023" @default.
- W4385907185 type Work @default.
- W4385907185 citedByCount "0" @default.
- W4385907185 crossrefType "journal-article" @default.
- W4385907185 hasAuthorship W4385907185A5001192465 @default.
- W4385907185 hasAuthorship W4385907185A5010513524 @default.
- W4385907185 hasAuthorship W4385907185A5013249076 @default.
- W4385907185 hasAuthorship W4385907185A5026254558 @default.
- W4385907185 hasAuthorship W4385907185A5034441524 @default.
- W4385907185 hasAuthorship W4385907185A5057636738 @default.
- W4385907185 hasAuthorship W4385907185A5063880800 @default.
- W4385907185 hasAuthorship W4385907185A5069514943 @default.
- W4385907185 hasAuthorship W4385907185A5070604004 @default.
- W4385907185 hasAuthorship W4385907185A5091313128 @default.
- W4385907185 hasBestOaLocation W43859071851 @default.
- W4385907185 hasConcept C126322002 @default.
- W4385907185 hasConcept C164705383 @default.
- W4385907185 hasConcept C177713679 @default.
- W4385907185 hasConcept C2776376669 @default.