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- W4385909227 abstract "Abstract Irinotecan (Ir) is commonly employed as a first-line chemotherapeutic treatment for colorectal cancer (CRC). However, tremendous impediments remain to be addressed to surmount drug resistance and ameliorate adverse events. Poly-ADP-Ribose Polymerase (PARP) participates in the maintenance of genome stability and the repair of DNA damage, thus playing a critical role in chemotherapy resistance. In this work, we introduce a novel curative strategy which utilizes nanoparticles (NPs) prepared by dynamic supramolecular co-assembly of Ir and a PARP inhibitor (PARPi) niraparib (Nir) through π-π stacking and hydrogen bond interactions. The Ir and Nir self-assembled Nano-Twin-Drug of (Nir-Ir NPs) could enhance efficacy against CRC by synergistically inhibiting the DNA damage repair pathway and activating the tumor cell apoptosis process without obvious toxicity. In addition, the Nir-Ir NPs could effectively reverse irinotecan-resistance by inhibiting the expression of multiple resistance protein-1 (MRP-1). Overall, our study underscores the distinctive advantages and potential of Nir-Ir NPs as a complementary strategy to chemotherapy by simultaneously overcoming the Ir resistance and improving the anti-tumor efficacy against CRC." @default.
- W4385909227 created "2023-08-18" @default.
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- W4385909227 date "2023-08-17" @default.
- W4385909227 modified "2023-09-29" @default.
- W4385909227 title "A Carrier-Free Supramolecular Nano-Twin-Drug for Overcoming Irinotecan- Resistance and Enhancing Efficacy against Colorectal Cancer" @default.
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- W4385909227 doi "https://doi.org/10.21203/rs.3.rs-3255371/v1" @default.
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