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• W4385948782 abstract "In this study, six compounds were obtained from a methanolic extract of air-dried leaves of Senna alata and one of them, a triterpenoid (secofriedelane) named as 7-(2-carboxyethyl)-3, 4b, 6a, 8, 10a, 12a-hexamethyl-8-vinyloctadecahydrochrysene-3-carboxylic acid (5) was isolated for the first time from this plant. Then, its chemical structure was detailed and characterised by FT-IR, 1H and 13C- NMR and ESI-MS. Besides, two chemical-modified derivatives of secofriedelane (5a, 5b) were synthesised by methylation and allylation reactions, respectively, and their in vitro antibacterial activities were also evaluated. The results revealed that all the triterpenes showed, against gram-positive and -negative bacterial strains, good and moderate antibacterial activities with bactericidal effects that were enhanced by the methyl groups and altered with the allyl ones. Moreover, the molecular docking results of 5, 5a and 5b in the DNA gyrase (2XCT) active site showed that triterpene 5 has a good score very close to reference (ciprofloxacin)." @default.
• W4385948782 created "2023-08-18" @default.
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• W4385948782 date "2023-08-17" @default.
• W4385948782 modified "2023-10-12" @default.
• W4385948782 title "<i>In vitro</i> and <i>in silico</i> studies of antibacterial activities of secofriedelane derivatives from <i>Senna alata</i> (L) Roxb" @default.
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• W4385948782 doi "https://doi.org/10.1080/14786419.2023.2247537" @default.
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• W4385948782 hasPublicationYear "2023" @default.
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