Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385950112> ?p ?o ?g. }
- W4385950112 abstract "Background The novel coronavirus disease 2019 (COVID-19) presents with complex pathophysiological effects in various organ systems. Following the COVID-19, there are shifts in biomarker and cytokine equilibrium associated with altered physiological processes arising from viral damage or aggressive immunological response. We hypothesized that high daily dose methylprednisolone improved the injury biomarkers and serum cytokine profiles in COVID-19 patients. Methods Injury biomarker and cytokine analysis was performed on 50 SARS-Cov-2 negative controls and 101 hospitalized severe COVID-19 patients: 49 methylprednisolone-treated (MP group) and 52 placebo-treated serum samples. Samples from the treated groups collected on days D1 (pre-treatment) all the groups, D7 (2 days after ending therapy) and D14 were analyzed. Luminex assay quantified the biomarkers HMGB1, FABP3, myoglobin, troponin I and NTproBNP. Immune mediators (CXCL8, CCL2, CXCL9, CXCL10, TNF, IFN-γ, IL-17A, IL-12p70, IL-10, IL-6, IL-4, IL-2, and IL-1β) were quantified using cytometric bead array. Results At pretreatment, the two treatment groups were comparable demographically. At pre-treatment (D1), injury biomarkers (HMGB1, TnI, myoglobin and FABP3) were distinctly elevated. At D7, HMGB1 was significantly higher in the MP group (p=0.0448) compared to the placebo group, while HMGB1 in the placebo group diminished significantly by D14 (p=0.0115). Compared to healthy control samples, several immune mediators (IL-17A, IL-6, IL-10, MIG, MCP-1, and IP-10) were considerably elevated at baseline (all p≤0.05). At D7, MIG and IP-10 of the MP-group were significantly lower than in the placebo-group (p=0.0431, p=0.0069, respectively). Longitudinally, IL-2 (MP-group) and IL-17A (placebo-group) had increased significantly by D14. In placebo group, IL-2 and IL-17A continuously increased, as IL-12p70, IL-10 and IP-10 steadily decreased during follow-up. The MP treated group had IL-2, IFN-γ, IL-17A and IL-12p70 progressively increase while IL-1β and IL-10 gradually decreased towards D14. Moderate to strong positive correlations between chemokines and cytokines were observed on D7 and D14. Conclusion These findings suggest MP treatment could ameliorate levels of myoglobin and FABP3, but appeared to have no impact on HMGB1, TnI and NTproBNP. In addition, methylprednisolone relieves the COVID-19 induced inflammatory response by diminishing MIG and IP-10 levels. Overall, corticosteroid (methylprednisolone) use in COVID-19 management influences the immunological molecule and injury biomarker profile in COVID-19 patients." @default.
- W4385950112 created "2023-08-18" @default.
- W4385950112 creator A5001446475 @default.
- W4385950112 creator A5002275313 @default.
- W4385950112 creator A5021346811 @default.
- W4385950112 creator A5024161412 @default.
- W4385950112 creator A5042712243 @default.
- W4385950112 creator A5047986349 @default.
- W4385950112 creator A5052250727 @default.
- W4385950112 creator A5055840657 @default.
- W4385950112 creator A5056292477 @default.
- W4385950112 creator A5059452672 @default.
- W4385950112 creator A5066418657 @default.
- W4385950112 creator A5066467922 @default.
- W4385950112 creator A5066653279 @default.
- W4385950112 creator A5068617807 @default.
- W4385950112 creator A5075439007 @default.
- W4385950112 creator A5080895560 @default.
- W4385950112 date "2023-08-16" @default.
- W4385950112 modified "2023-10-17" @default.
- W4385950112 title "Temporal patterns of cytokine and injury biomarkers in hospitalized COVID-19 patients treated with methylprednisolone" @default.
- W4385950112 cites W1542668411 @default.
- W4385950112 cites W1968802386 @default.
- W4385950112 cites W1976858929 @default.
- W4385950112 cites W1981698321 @default.
- W4385950112 cites W2012010986 @default.
- W4385950112 cites W2029668372 @default.
- W4385950112 cites W2036384654 @default.
- W4385950112 cites W2049696083 @default.
- W4385950112 cites W2055617964 @default.
- W4385950112 cites W2065744527 @default.
- W4385950112 cites W2070463916 @default.
- W4385950112 cites W2071468584 @default.
- W4385950112 cites W2077752217 @default.
- W4385950112 cites W2104414795 @default.
- W4385950112 cites W2141029513 @default.
- W4385950112 cites W2166726995 @default.
- W4385950112 cites W2467515438 @default.
- W4385950112 cites W2547214152 @default.
- W4385950112 cites W2770893462 @default.
- W4385950112 cites W2779202511 @default.
- W4385950112 cites W2780787390 @default.
- W4385950112 cites W2805147785 @default.
- W4385950112 cites W2974490667 @default.
- W4385950112 cites W3002108456 @default.
- W4385950112 cites W3005403371 @default.
- W4385950112 cites W3006873276 @default.
- W4385950112 cites W3009859788 @default.
- W4385950112 cites W3009912996 @default.
- W4385950112 cites W3010699833 @default.
- W4385950112 cites W3011610993 @default.
- W4385950112 cites W3012849736 @default.
- W4385950112 cites W3013094207 @default.
- W4385950112 cites W3013893688 @default.
- W4385950112 cites W3014099229 @default.
- W4385950112 cites W3015849236 @default.
- W4385950112 cites W3016127406 @default.
- W4385950112 cites W3020593113 @default.
- W4385950112 cites W3023125802 @default.
- W4385950112 cites W3023264778 @default.
- W4385950112 cites W3024651542 @default.
- W4385950112 cites W3027154555 @default.
- W4385950112 cites W3032427039 @default.
- W4385950112 cites W3033072986 @default.
- W4385950112 cites W3036931136 @default.
- W4385950112 cites W3037135479 @default.
- W4385950112 cites W3040531409 @default.
- W4385950112 cites W3041275036 @default.
- W4385950112 cites W3042170621 @default.
- W4385950112 cites W3044219705 @default.
- W4385950112 cites W3044898763 @default.
- W4385950112 cites W3045910809 @default.
- W4385950112 cites W3045925312 @default.
- W4385950112 cites W3048510827 @default.
- W4385950112 cites W3049206116 @default.
- W4385950112 cites W3083964891 @default.
- W4385950112 cites W3086748853 @default.
- W4385950112 cites W3091510250 @default.
- W4385950112 cites W3094419073 @default.
- W4385950112 cites W3096383810 @default.
- W4385950112 cites W3096788461 @default.
- W4385950112 cites W3097641691 @default.
- W4385950112 cites W3107226474 @default.
- W4385950112 cites W3113136031 @default.
- W4385950112 cites W3117552014 @default.
- W4385950112 cites W3118418470 @default.
- W4385950112 cites W3123425658 @default.
- W4385950112 cites W3127761604 @default.
- W4385950112 cites W3129598140 @default.
- W4385950112 cites W3131658864 @default.
- W4385950112 cites W3134752981 @default.
- W4385950112 cites W3135692744 @default.
- W4385950112 cites W3146509987 @default.
- W4385950112 cites W3150010507 @default.
- W4385950112 cites W3158024242 @default.
- W4385950112 cites W3158025673 @default.
- W4385950112 cites W3162242396 @default.
- W4385950112 cites W3163668768 @default.
- W4385950112 cites W3163889992 @default.
- W4385950112 cites W3165209070 @default.