Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385952067> ?p ?o ?g. }
- W4385952067 abstract "Abstract In preclinical studies rapamycin was found to target neuroinflammation, by expanding regulatory T cells, and affecting autophagy, two pillars of amyotrophic lateral sclerosis (ALS) pathogenesis. Herein we report a multicenter, randomized, double-blind trial, in 63 ALS patients who were randomly assigned in a 1:1:1 ratio to receive rapamycin 2 mg/m 2 /day,1 mg/m 2 /day or placebo (EUDRACT 2016-002399-28; NCT03359538). The primary outcome, the number of patients exhibiting an increase >30% in regulatory T cells from baseline to treatment end, was not attained. Secondary outcomes were changes from baseline of T, B, NK cell subpopulations, inflammasome mRNA expression and activation status, S6-ribosomal protein phosphorylation, neurofilaments; clinical outcome measures of disease progression; survival; safety and quality of life. Of the secondary outcomes, rapamycin decreased mRNA relative expression of the pro-inflammatory cytokine IL-18, reduced plasmatic IL-18 protein, and increased the percentage of classical monocytes and memory switched B cells, although no corrections were applied for multiple tests. In conclusion, we show that rapamycin treatment is well tolerated and provides reassuring safety findings in ALS patients, but further trials are necessary to understand the biological and clinical effects of this drug in ALS." @default.
- W4385952067 created "2023-08-18" @default.
- W4385952067 creator A5002986919 @default.
- W4385952067 creator A5009246047 @default.
- W4385952067 creator A5013376058 @default.
- W4385952067 creator A5016543092 @default.
- W4385952067 creator A5016597149 @default.
- W4385952067 creator A5017248165 @default.
- W4385952067 creator A5018307013 @default.
- W4385952067 creator A5018495982 @default.
- W4385952067 creator A5030759670 @default.
- W4385952067 creator A5032127278 @default.
- W4385952067 creator A5046669478 @default.
- W4385952067 creator A5047408204 @default.
- W4385952067 creator A5049549975 @default.
- W4385952067 creator A5053444531 @default.
- W4385952067 creator A5053912816 @default.
- W4385952067 creator A5057331951 @default.
- W4385952067 creator A5061314842 @default.
- W4385952067 creator A5061442440 @default.
- W4385952067 creator A5061958104 @default.
- W4385952067 creator A5065494227 @default.
- W4385952067 creator A5065891865 @default.
- W4385952067 creator A5074413162 @default.
- W4385952067 creator A5076109679 @default.
- W4385952067 creator A5079996196 @default.
- W4385952067 creator A5081609640 @default.
- W4385952067 creator A5083279701 @default.
- W4385952067 creator A5008531728 @default.
- W4385952067 date "2023-08-17" @default.
- W4385952067 modified "2023-10-17" @default.
- W4385952067 title "Randomized, double-blind, placebo-controlled trial of rapamycin in amyotrophic lateral sclerosis" @default.
- W4385952067 cites W1812777905 @default.
- W4385952067 cites W1976266513 @default.
- W4385952067 cites W1985403672 @default.
- W4385952067 cites W1996815931 @default.
- W4385952067 cites W1996973828 @default.
- W4385952067 cites W1999522052 @default.
- W4385952067 cites W2025617070 @default.
- W4385952067 cites W2038252997 @default.
- W4385952067 cites W2053095572 @default.
- W4385952067 cites W2086639871 @default.
- W4385952067 cites W2111425566 @default.
- W4385952067 cites W2111444310 @default.
- W4385952067 cites W2111567059 @default.
- W4385952067 cites W2122971119 @default.
- W4385952067 cites W2155383466 @default.
- W4385952067 cites W2160706595 @default.
- W4385952067 cites W2511577826 @default.
- W4385952067 cites W2556818673 @default.
- W4385952067 cites W2594565722 @default.
- W4385952067 cites W2755021293 @default.
- W4385952067 cites W2761403361 @default.
- W4385952067 cites W2781022342 @default.
- W4385952067 cites W2807994366 @default.
- W4385952067 cites W3020357428 @default.
- W4385952067 cites W3040840440 @default.
- W4385952067 cites W3082122716 @default.
- W4385952067 cites W3082669542 @default.
- W4385952067 cites W3087214975 @default.
- W4385952067 cites W3118036084 @default.
- W4385952067 cites W3159328850 @default.
- W4385952067 cites W3169055556 @default.
- W4385952067 cites W3174108400 @default.
- W4385952067 cites W3174367383 @default.
- W4385952067 cites W4220985999 @default.
- W4385952067 cites W4226109550 @default.
- W4385952067 cites W4283447247 @default.
- W4385952067 cites W4291221238 @default.
- W4385952067 cites W4306663330 @default.
- W4385952067 cites W4308590523 @default.
- W4385952067 cites W4323920768 @default.
- W4385952067 cites W3200207163 @default.
- W4385952067 doi "https://doi.org/10.1038/s41467-023-40734-8" @default.
- W4385952067 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37591957" @default.
- W4385952067 hasPublicationYear "2023" @default.
- W4385952067 type Work @default.
- W4385952067 citedByCount "0" @default.
- W4385952067 crossrefType "journal-article" @default.
- W4385952067 hasAuthorship W4385952067A5002986919 @default.
- W4385952067 hasAuthorship W4385952067A5008531728 @default.
- W4385952067 hasAuthorship W4385952067A5009246047 @default.
- W4385952067 hasAuthorship W4385952067A5013376058 @default.
- W4385952067 hasAuthorship W4385952067A5016543092 @default.
- W4385952067 hasAuthorship W4385952067A5016597149 @default.
- W4385952067 hasAuthorship W4385952067A5017248165 @default.
- W4385952067 hasAuthorship W4385952067A5018307013 @default.
- W4385952067 hasAuthorship W4385952067A5018495982 @default.
- W4385952067 hasAuthorship W4385952067A5030759670 @default.
- W4385952067 hasAuthorship W4385952067A5032127278 @default.
- W4385952067 hasAuthorship W4385952067A5046669478 @default.
- W4385952067 hasAuthorship W4385952067A5047408204 @default.
- W4385952067 hasAuthorship W4385952067A5049549975 @default.
- W4385952067 hasAuthorship W4385952067A5053444531 @default.
- W4385952067 hasAuthorship W4385952067A5053912816 @default.
- W4385952067 hasAuthorship W4385952067A5057331951 @default.
- W4385952067 hasAuthorship W4385952067A5061314842 @default.
- W4385952067 hasAuthorship W4385952067A5061442440 @default.
- W4385952067 hasAuthorship W4385952067A5061958104 @default.
- W4385952067 hasAuthorship W4385952067A5065494227 @default.