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- W4385952701 abstract "Upon completion, participants will be able to gain knowledge on what are prebiotics, why pulses-derived resistant starch can be considered as a prebiotic and how prebiotics beneficially effect the host. Poor nutrition (e.g., decreased fiber intake) in later life associated with increased predisposition to several cardiometabolic diseases. To address this, the current investigation aimed to explore the prebiotic potential of resistant starch (RS) extracted from fiber-rich dietary pulses in modulating the gut and metabolic health of an aged host using a humanized murine model of aging. C57B6/J mice transplanted with human gut microbiome were fed specialized diets for 20 weeks: western-style high-fat diet (control; CTL) or CTL diet supplemented (5% w/w) with RS from pinto beans (PTB), black-eyed-peas (BEP), lentils (LEN), chickpeas (CKP), or inulin (INU; reference control). Illumina-based 16S rRNA gene sequencing and NMR-based untargeted metabolomics were performed on fecal samples. Glycemic response ascertained using meal tolerance test. RT-PCR gene expression performed for intestinal inflammatory markers and tight-junction proteins RS supplementation yielded sex-specific unique alterations in gut microbiome and fecal metabolome profiles. LEN group increased Firmicutes’ abundance with butyrate levels, whereas INU resulted in increased Bacteroidota with propionate production. Several notorious genera viz., Enterococcus, Odoribacter, Alistipes and Desulfovibrio decreased following RS intervention. Amino acid metabolism was positively altered together with reduction in total bile acids and cholesterol post RS treatment. LEN and CKP reduced postprandial glycemia in males. RS ameliorated gut hyperpermeability and enhanced epithelial expression of tight-junction proteins. Additionally, IL10 and TNF-α were upregulated and downregulated, respectively by LEN, CKP and INU groups. The study demonstrated prebiotic potential of pulses-derived RS, suggesting its dietary supplementation to address ‘dietary fiber gap’ of growing elderly population." @default.
- W4385952701 created "2023-08-18" @default.
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- W4385952701 date "2023-09-01" @default.
- W4385952701 modified "2023-10-05" @default.
- W4385952701 title "Understanding the Prebiotic Effects of Dietary Pulses Derived Resistant Starch in Improving Gut and Metabolic Health in a Preclinical Humanized Model of Ageing" @default.
- W4385952701 doi "https://doi.org/10.1016/j.jand.2023.06.270" @default.
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