Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385954177> ?p ?o ?g. }
- W4385954177 abstract "Foxo1 upregulation is linked to defective fracture healing under diabetic conditions. Previous studies demonstrated that diabetes upregulates Foxo1 expression and activation and diabetes impairs ciliogenesis resulting in defective fracture repair. However, the mechanism by which diabetes causes cilia loss during fracture healing remains elusive. We report here that streptozotocin (STZ)-induced type 1 diabetes mellitus (T1DM) dramatically increased Foxo1 expression in femoral fracture calluses, which thereby caused a significant decrease in the expression of IFT80 and primary cilia number. Ablation of Foxo1 in osteoblasts in OSXcretTAFoxo1f/f mice rescued IFT80 expression and ciliogenesis and restored bone formation and mechanical strength in diabetic fracture calluses. In vitro, advanced glycation end products (AGEs) impaired cilia formation in osteoblasts and reduced the production of a mineralizing matrix, which were rescued by Foxo1 deletion. Mechanistically, AGEs increased Foxo1 expression and transcriptional activity to inhibit IFT80 expression causing impaired cilia formation. Thus, our findings demonstrate that diabetes impairs fracture healing through Foxo1 mediated inhibition of ciliary IFT80 expression and primary cilia formation, resulting in impaired osteogenesis. Inhibition of Foxo1 and/or restoration of cilia formation has the potential to promote diabetes-impaired fracture healing." @default.
- W4385954177 created "2023-08-18" @default.
- W4385954177 creator A5017353282 @default.
- W4385954177 creator A5034694040 @default.
- W4385954177 creator A5050335459 @default.
- W4385954177 creator A5056774287 @default.
- W4385954177 creator A5082155425 @default.
- W4385954177 date "2023-08-17" @default.
- W4385954177 modified "2023-10-16" @default.
- W4385954177 title "Diabetes impairs fracture healing through Foxo1 mediated disruption of ciliogenesis" @default.
- W4385954177 cites W1048885802 @default.
- W4385954177 cites W162961686 @default.
- W4385954177 cites W1970231717 @default.
- W4385954177 cites W1971206408 @default.
- W4385954177 cites W1971706608 @default.
- W4385954177 cites W1976718809 @default.
- W4385954177 cites W1981987409 @default.
- W4385954177 cites W1984247031 @default.
- W4385954177 cites W1988533223 @default.
- W4385954177 cites W2010291190 @default.
- W4385954177 cites W2030700131 @default.
- W4385954177 cites W2031165650 @default.
- W4385954177 cites W2042361253 @default.
- W4385954177 cites W2044723012 @default.
- W4385954177 cites W2046723511 @default.
- W4385954177 cites W2053940222 @default.
- W4385954177 cites W2080094674 @default.
- W4385954177 cites W2129618055 @default.
- W4385954177 cites W2166977115 @default.
- W4385954177 cites W2311799170 @default.
- W4385954177 cites W2516488633 @default.
- W4385954177 cites W256356543 @default.
- W4385954177 cites W2737930891 @default.
- W4385954177 cites W2751828697 @default.
- W4385954177 cites W2896714748 @default.
- W4385954177 cites W2910804142 @default.
- W4385954177 cites W2923091617 @default.
- W4385954177 cites W2981860717 @default.
- W4385954177 cites W3001506028 @default.
- W4385954177 cites W3028078262 @default.
- W4385954177 cites W3097966074 @default.
- W4385954177 cites W3133963655 @default.
- W4385954177 cites W3197042392 @default.
- W4385954177 cites W4211143281 @default.
- W4385954177 cites W4220904561 @default.
- W4385954177 cites W4311957263 @default.
- W4385954177 doi "https://doi.org/10.1038/s41420-023-01562-3" @default.
- W4385954177 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37591875" @default.
- W4385954177 hasPublicationYear "2023" @default.
- W4385954177 type Work @default.
- W4385954177 citedByCount "0" @default.
- W4385954177 crossrefType "journal-article" @default.
- W4385954177 hasAuthorship W4385954177A5017353282 @default.
- W4385954177 hasAuthorship W4385954177A5034694040 @default.
- W4385954177 hasAuthorship W4385954177A5050335459 @default.
- W4385954177 hasAuthorship W4385954177A5056774287 @default.
- W4385954177 hasAuthorship W4385954177A5082155425 @default.
- W4385954177 hasBestOaLocation W43859541771 @default.
- W4385954177 hasConcept C100094513 @default.
- W4385954177 hasConcept C104317684 @default.
- W4385954177 hasConcept C126322002 @default.
- W4385954177 hasConcept C127561419 @default.
- W4385954177 hasConcept C134018914 @default.
- W4385954177 hasConcept C140149449 @default.
- W4385954177 hasConcept C141071460 @default.
- W4385954177 hasConcept C147990577 @default.
- W4385954177 hasConcept C185592680 @default.
- W4385954177 hasConcept C195267511 @default.
- W4385954177 hasConcept C55493867 @default.
- W4385954177 hasConcept C555293320 @default.
- W4385954177 hasConcept C62478195 @default.
- W4385954177 hasConcept C71924100 @default.
- W4385954177 hasConcept C75217442 @default.
- W4385954177 hasConcept C8337478 @default.
- W4385954177 hasConcept C86803240 @default.
- W4385954177 hasConcept C95444343 @default.
- W4385954177 hasConceptScore W4385954177C100094513 @default.
- W4385954177 hasConceptScore W4385954177C104317684 @default.
- W4385954177 hasConceptScore W4385954177C126322002 @default.
- W4385954177 hasConceptScore W4385954177C127561419 @default.
- W4385954177 hasConceptScore W4385954177C134018914 @default.
- W4385954177 hasConceptScore W4385954177C140149449 @default.
- W4385954177 hasConceptScore W4385954177C141071460 @default.
- W4385954177 hasConceptScore W4385954177C147990577 @default.
- W4385954177 hasConceptScore W4385954177C185592680 @default.
- W4385954177 hasConceptScore W4385954177C195267511 @default.
- W4385954177 hasConceptScore W4385954177C55493867 @default.
- W4385954177 hasConceptScore W4385954177C555293320 @default.
- W4385954177 hasConceptScore W4385954177C62478195 @default.
- W4385954177 hasConceptScore W4385954177C71924100 @default.
- W4385954177 hasConceptScore W4385954177C75217442 @default.
- W4385954177 hasConceptScore W4385954177C8337478 @default.
- W4385954177 hasConceptScore W4385954177C86803240 @default.
- W4385954177 hasConceptScore W4385954177C95444343 @default.
- W4385954177 hasFunder F4320337362 @default.
- W4385954177 hasFunder F4320337365 @default.
- W4385954177 hasIssue "1" @default.
- W4385954177 hasLocation W43859541771 @default.
- W4385954177 hasLocation W43859541772 @default.
- W4385954177 hasLocation W43859541773 @default.