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• W4385954718 abstract "This study was conducted to evaluate the cognitive dysfunction improvement effect of aqueous extract of Codium fragile (AECF) by regulating the imbalance of the gut–brain axis in chronic particulate matter (PM)2.5-exposed mice. The physiological compounds of AECF were identified as hexadecanamide, oleamide, octadecanamide, stearidonic acid, and linolenic acid by the ultra-performance liquid chromatography-quadrupole time of flight mass spectrometry (UPLC Q-TOF MSE) analysis. To evaluate the effect of PM2.5 on the antioxidant system, superoxide dismutase (SOD) contents, reduced glutathione (GSH) contents, and malondialdehyde (MDA) contents were measured in colon and brain tissues. AECF significantly ameliorated the imbalance of the antioxidant systems. Also, AECF improved intestinal myeloperoxidase (MPO) activity, the abundance of the gut microbiome, short-chain fatty acids (SCFAs) contents, and tight junction protein expression against PM2.5-induced damage. In addition, AECF prevented PM2.5-induced inflammatory and apoptotic expression via the toll-like receptor-4 (TLR-4)/myeloid differentiation primary response 88 (MyD88) pathway in colon and brain tissues. Additionally, AECF enhanced the mitochondrial function, including the mitochondrial membrane potential (MMP) and reactive oxygen species (ROS) contents in brain tissues. Furthermore, AECF regulated the cholinergic system, such as acetylcholine (ACh) contents, acetylcholinesterase (AChE) activity, and protein expression levels of AChE and choline acetyltransferase (ChAT) in brain tissues. To evaluate the effect of cognitive dysfunction caused by PM2.5-induced intestinal dysfunction, behavior tests such as Y-maze, passive avoidance, and Morris water maze tests were performed. From the results of the behavior tests, AECF ameliorated spatial learning and memory, short-term memory, and long-term learning and memory function. This study confirmed that AECF reduced PM2.5-induced cognitive dysfunction by regulating gut microbiome and inflammation, apoptosis, and mitochondrial function by enhancing the gut–brain axis. Based on these results, this study suggests that AECF, which contains fatty acid amides, might be a potential material for ameliorating PM2.5-induced cognitive dysfunction via gut–brain axis improvement." @default.
• W4385954718 created "2023-08-18" @default.
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• W4385954718 date "2023-08-17" @default.
• W4385954718 modified "2023-10-14" @default.
• W4385954718 title "Codium fragile Suppresses PM2.5-Induced Cognitive Dysfunction by Regulating Gut–Brain Axis via TLR-4/MyD88 Pathway" @default.
• W4385954718 cites W1494360569 @default.
• W4385954718 cites W1614117239 @default.
• W4385954718 cites W1797297565 @default.
• W4385954718 cites W1912700599 @default.
• W4385954718 cites W1971048984 @default.
• W4385954718 cites W1972095764 @default.
• W4385954718 cites W1976870277 @default.
• W4385954718 cites W1977291093 @default.
• W4385954718 cites W1992282049 @default.
• W4385954718 cites W1995193883 @default.
• W4385954718 cites W1997191564 @default.
• W4385954718 cites W1999177172 @default.
• W4385954718 cites W1999272644 @default.
• W4385954718 cites W2005064739 @default.
• W4385954718 cites W2006157649 @default.
• W4385954718 cites W2008448408 @default.
• W4385954718 cites W2012606594 @default.
• W4385954718 cites W2014745197 @default.
• W4385954718 cites W2019582654 @default.
• W4385954718 cites W2020398205 @default.
• W4385954718 cites W2026261400 @default.
• W4385954718 cites W2035537160 @default.
• W4385954718 cites W2038064966 @default.
• W4385954718 cites W2039471616 @default.
• W4385954718 cites W2042263204 @default.
• W4385954718 cites W2042879438 @default.
• W4385954718 cites W2056036338 @default.
• W4385954718 cites W2059277649 @default.
• W4385954718 cites W2080963939 @default.
• W4385954718 cites W2088665897 @default.
• W4385954718 cites W2090076381 @default.
• W4385954718 cites W2122772258 @default.
• W4385954718 cites W2125381661 @default.
• W4385954718 cites W2128635872 @default.
• W4385954718 cites W2131118500 @default.
• W4385954718 cites W2131169527 @default.
• W4385954718 cites W2146532249 @default.
• W4385954718 cites W2159197667 @default.
• W4385954718 cites W2161764972 @default.
• W4385954718 cites W2169473035 @default.
• W4385954718 cites W2257198177 @default.
• W4385954718 cites W2275537745 @default.
• W4385954718 cites W2489029810 @default.
• W4385954718 cites W2508213551 @default.
• W4385954718 cites W2521751481 @default.
• W4385954718 cites W2575605891 @default.
• W4385954718 cites W2582797467 @default.
• W4385954718 cites W2595321304 @default.
• W4385954718 cites W2621030068 @default.
• W4385954718 cites W2735527928 @default.
• W4385954718 cites W2737944606 @default.
• W4385954718 cites W2762068253 @default.
• W4385954718 cites W2765237212 @default.
• W4385954718 cites W2767322666 @default.
• W4385954718 cites W2792025613 @default.
• W4385954718 cites W2792526694 @default.
• W4385954718 cites W2804679688 @default.
• W4385954718 cites W2892119478 @default.
• W4385954718 cites W2902049322 @default.
• W4385954718 cites W2919054694 @default.
• W4385954718 cites W2921966151 @default.
• W4385954718 cites W2931382420 @default.
• W4385954718 cites W2937201376 @default.
• W4385954718 cites W2947264263 @default.
• W4385954718 cites W2960695456 @default.
• W4385954718 cites W2973441482 @default.
• W4385954718 cites W2987356303 @default.
• W4385954718 cites W3001233619 @default.
• W4385954718 cites W3004007042 @default.
• W4385954718 cites W3007002887 @default.
• W4385954718 cites W3024427377 @default.
• W4385954718 cites W3026043737 @default.
• W4385954718 cites W3026296114 @default.
• W4385954718 cites W3082443534 @default.
• W4385954718 cites W3083563735 @default.
• W4385954718 cites W3110713218 @default.
• W4385954718 cites W3111760191 @default.
• W4385954718 cites W3111897458 @default.
• W4385954718 cites W3134465013 @default.
• W4385954718 cites W3135117422 @default.
• W4385954718 cites W3138746800 @default.
• W4385954718 cites W3139370465 @default.
• W4385954718 cites W3148286855 @default.

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