Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385955496> ?p ?o ?g. }
- W4385955496 endingPage "1667" @default.
- W4385955496 startingPage "1653" @default.
- W4385955496 abstract "Chikungunya virus (CHIKV) has recently emerged to cause millions of human infections worldwide. Infection can induce the formation of long intercellular extensions that project from infected cells and form stable non-continuous membrane bridges with neighbouring cells. The mechanistic role of these intercellular extensions in CHIKV infection was unclear. Here we developed a co-culture system and flow cytometry methods to quantitatively evaluate transmission of CHIKV from infected to uninfected cells in the presence of neutralizing antibody. Endocytosis and endosomal acidification were critical for virus cell-to-cell transmission, while the CHIKV receptor MXRA8 was not. By using distinct antibodies to block formation of extensions and by evaluation of transmission in HeLa cells that did not form extensions, we showed that intercellular extensions mediate CHIKV cell-to-cell transmission. In vivo, pre-treatment of mice with a neutralizing antibody blocked infection by direct virus inoculation, while adoptive transfer of infected cells produced antibody-resistant host infection. Together our data suggest a model in which the contact sites of intercellular extensions on target cells shield CHIKV from neutralizing antibodies and promote efficient intercellular virus transmission both in vitro and in vivo. Filopodia-like extensions connect chikungunya virus-infected and non-infected cells and promote efficient viral transmission by shielding from neutralizing antibodies." @default.
- W4385955496 created "2023-08-18" @default.
- W4385955496 creator A5002509270 @default.
- W4385955496 creator A5008833439 @default.
- W4385955496 creator A5030038763 @default.
- W4385955496 creator A5034932037 @default.
- W4385955496 creator A5037893819 @default.
- W4385955496 creator A5047702020 @default.
- W4385955496 creator A5059043595 @default.
- W4385955496 creator A5061677067 @default.
- W4385955496 creator A5066356842 @default.
- W4385955496 creator A5070153307 @default.
- W4385955496 creator A5076442194 @default.
- W4385955496 creator A5077956284 @default.
- W4385955496 date "2023-08-17" @default.
- W4385955496 modified "2023-10-16" @default.
- W4385955496 title "Chikungunya virus cell-to-cell transmission is mediated by intercellular extensions in vitro and in vivo" @default.
- W4385955496 cites W1526128150 @default.
- W4385955496 cites W1585777045 @default.
- W4385955496 cites W1606338704 @default.
- W4385955496 cites W1619221212 @default.
- W4385955496 cites W1657414671 @default.
- W4385955496 cites W1756184344 @default.
- W4385955496 cites W1938711525 @default.
- W4385955496 cites W1966635724 @default.
- W4385955496 cites W1968517266 @default.
- W4385955496 cites W1983853508 @default.
- W4385955496 cites W2039667276 @default.
- W4385955496 cites W2045688769 @default.
- W4385955496 cites W2047440919 @default.
- W4385955496 cites W2049676886 @default.
- W4385955496 cites W2051695714 @default.
- W4385955496 cites W2063825303 @default.
- W4385955496 cites W2069487448 @default.
- W4385955496 cites W2076354932 @default.
- W4385955496 cites W2083889661 @default.
- W4385955496 cites W2088757776 @default.
- W4385955496 cites W2099540110 @default.
- W4385955496 cites W2130810814 @default.
- W4385955496 cites W2132117914 @default.
- W4385955496 cites W2136631930 @default.
- W4385955496 cites W2136958613 @default.
- W4385955496 cites W2140895863 @default.
- W4385955496 cites W2141231462 @default.
- W4385955496 cites W2141918346 @default.
- W4385955496 cites W2158760156 @default.
- W4385955496 cites W2213001499 @default.
- W4385955496 cites W2259698181 @default.
- W4385955496 cites W2284046515 @default.
- W4385955496 cites W2343619545 @default.
- W4385955496 cites W2487259150 @default.
- W4385955496 cites W2504702569 @default.
- W4385955496 cites W2565736463 @default.
- W4385955496 cites W2588207450 @default.
- W4385955496 cites W2594220414 @default.
- W4385955496 cites W2791130803 @default.
- W4385955496 cites W2803841447 @default.
- W4385955496 cites W2808132849 @default.
- W4385955496 cites W2908960338 @default.
- W4385955496 cites W2912729722 @default.
- W4385955496 cites W2915816290 @default.
- W4385955496 cites W2945892221 @default.
- W4385955496 cites W2970420961 @default.
- W4385955496 cites W2972007636 @default.
- W4385955496 cites W2987130288 @default.
- W4385955496 cites W3041706312 @default.
- W4385955496 cites W3090421815 @default.
- W4385955496 cites W3094584667 @default.
- W4385955496 cites W84426258 @default.
- W4385955496 doi "https://doi.org/10.1038/s41564-023-01449-0" @default.
- W4385955496 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37591996" @default.
- W4385955496 hasPublicationYear "2023" @default.
- W4385955496 type Work @default.
- W4385955496 citedByCount "1" @default.
- W4385955496 countsByYear W43859554962023 @default.
- W4385955496 crossrefType "journal-article" @default.
- W4385955496 hasAuthorship W4385955496A5002509270 @default.
- W4385955496 hasAuthorship W4385955496A5008833439 @default.
- W4385955496 hasAuthorship W4385955496A5030038763 @default.
- W4385955496 hasAuthorship W4385955496A5034932037 @default.
- W4385955496 hasAuthorship W4385955496A5037893819 @default.
- W4385955496 hasAuthorship W4385955496A5047702020 @default.
- W4385955496 hasAuthorship W4385955496A5059043595 @default.
- W4385955496 hasAuthorship W4385955496A5061677067 @default.
- W4385955496 hasAuthorship W4385955496A5066356842 @default.
- W4385955496 hasAuthorship W4385955496A5070153307 @default.
- W4385955496 hasAuthorship W4385955496A5076442194 @default.
- W4385955496 hasAuthorship W4385955496A5077956284 @default.
- W4385955496 hasConcept C140704245 @default.
- W4385955496 hasConcept C1491633281 @default.
- W4385955496 hasConcept C159047783 @default.
- W4385955496 hasConcept C159654299 @default.
- W4385955496 hasConcept C196594336 @default.
- W4385955496 hasConcept C203014093 @default.
- W4385955496 hasConcept C2522874641 @default.
- W4385955496 hasConcept C2779261636 @default.
- W4385955496 hasConcept C2781273456 @default.
- W4385955496 hasConcept C28005876 @default.