Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385955981> ?p ?o ?g. }
- W4385955981 endingPage "1853" @default.
- W4385955981 startingPage "1841" @default.
- W4385955981 abstract "AT2 cells harbor alveolar stem cell activity in the lung and can self-renew and differentiate into AT1 cells during homeostasis and after injury. To identify epigenetic pathways that control the AT2-AT1 regenerative response in the lung, we performed an organoid screen using a library of pharmacological epigenetic inhibitors. This screen identified DOT1L as a regulator of AT2 cell growth and differentiation. In vivo inactivation of Dot1l leads to precocious activation of both AT1 and AT2 gene expression during lung development and accelerated AT1 cell differentiation after acute lung injury. Single-cell transcriptome analysis reveals the presence of a new AT2 cell state upon loss of Dot1l, characterized by increased expression of oxidative phosphorylation genes and changes in expression of critical transcription and epigenetic factors. Taken together, these data demonstrate that Dot1l controls the rate of alveolar epithelial cell fate acquisition during development and regeneration after acute injury." @default.
- W4385955981 created "2023-08-18" @default.
- W4385955981 creator A5003101072 @default.
- W4385955981 creator A5020690590 @default.
- W4385955981 creator A5023208871 @default.
- W4385955981 creator A5062292129 @default.
- W4385955981 creator A5064809970 @default.
- W4385955981 creator A5064965148 @default.
- W4385955981 creator A5065670232 @default.
- W4385955981 creator A5072731127 @default.
- W4385955981 creator A5077653394 @default.
- W4385955981 creator A5078196069 @default.
- W4385955981 date "2023-09-01" @default.
- W4385955981 modified "2023-10-17" @default.
- W4385955981 title "DOT1L regulates lung developmental epithelial cell fate and adult alveolar stem cell differentiation after acute injury" @default.
- W4385955981 cites W1832820770 @default.
- W4385955981 cites W2005829971 @default.
- W4385955981 cites W2064315321 @default.
- W4385955981 cites W2091208410 @default.
- W4385955981 cites W2101979131 @default.
- W4385955981 cites W2104954848 @default.
- W4385955981 cites W2120876285 @default.
- W4385955981 cites W2140765582 @default.
- W4385955981 cites W2161282017 @default.
- W4385955981 cites W2170444631 @default.
- W4385955981 cites W2263021307 @default.
- W4385955981 cites W2344060249 @default.
- W4385955981 cites W2346501107 @default.
- W4385955981 cites W2552834938 @default.
- W4385955981 cites W2766968008 @default.
- W4385955981 cites W2786421413 @default.
- W4385955981 cites W2787299394 @default.
- W4385955981 cites W2788439692 @default.
- W4385955981 cites W2791712220 @default.
- W4385955981 cites W2800406470 @default.
- W4385955981 cites W2902599110 @default.
- W4385955981 cites W2917661393 @default.
- W4385955981 cites W2951546294 @default.
- W4385955981 cites W2951703547 @default.
- W4385955981 cites W2951799803 @default.
- W4385955981 cites W2990280798 @default.
- W4385955981 cites W3006552983 @default.
- W4385955981 cites W3014259712 @default.
- W4385955981 cites W3040811143 @default.
- W4385955981 cites W3043344901 @default.
- W4385955981 cites W3047493479 @default.
- W4385955981 cites W3119067519 @default.
- W4385955981 cites W3135360764 @default.
- W4385955981 cites W3161329726 @default.
- W4385955981 cites W3163266086 @default.
- W4385955981 cites W3184530143 @default.
- W4385955981 cites W3205418932 @default.
- W4385955981 cites W3206071748 @default.
- W4385955981 cites W4221078835 @default.
- W4385955981 cites W4233089886 @default.
- W4385955981 cites W4284888512 @default.
- W4385955981 cites W4288081004 @default.
- W4385955981 cites W4315928671 @default.
- W4385955981 doi "https://doi.org/10.1016/j.stemcr.2023.07.006" @default.
- W4385955981 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37595582" @default.
- W4385955981 hasPublicationYear "2023" @default.
- W4385955981 type Work @default.
- W4385955981 citedByCount "0" @default.
- W4385955981 crossrefType "journal-article" @default.
- W4385955981 hasAuthorship W4385955981A5003101072 @default.
- W4385955981 hasAuthorship W4385955981A5020690590 @default.
- W4385955981 hasAuthorship W4385955981A5023208871 @default.
- W4385955981 hasAuthorship W4385955981A5062292129 @default.
- W4385955981 hasAuthorship W4385955981A5064809970 @default.
- W4385955981 hasAuthorship W4385955981A5064965148 @default.
- W4385955981 hasAuthorship W4385955981A5065670232 @default.
- W4385955981 hasAuthorship W4385955981A5072731127 @default.
- W4385955981 hasAuthorship W4385955981A5077653394 @default.
- W4385955981 hasAuthorship W4385955981A5078196069 @default.
- W4385955981 hasBestOaLocation W43859559811 @default.
- W4385955981 hasConcept C104317684 @default.
- W4385955981 hasConcept C148738053 @default.
- W4385955981 hasConcept C1491633281 @default.
- W4385955981 hasConcept C150194340 @default.
- W4385955981 hasConcept C162317418 @default.
- W4385955981 hasConcept C163952510 @default.
- W4385955981 hasConcept C171056886 @default.
- W4385955981 hasConcept C203014093 @default.
- W4385955981 hasConcept C28328180 @default.
- W4385955981 hasConcept C41091548 @default.
- W4385955981 hasConcept C54355233 @default.
- W4385955981 hasConcept C62112901 @default.
- W4385955981 hasConcept C86339819 @default.
- W4385955981 hasConcept C86803240 @default.
- W4385955981 hasConcept C95444343 @default.
- W4385955981 hasConceptScore W4385955981C104317684 @default.
- W4385955981 hasConceptScore W4385955981C148738053 @default.
- W4385955981 hasConceptScore W4385955981C1491633281 @default.
- W4385955981 hasConceptScore W4385955981C150194340 @default.
- W4385955981 hasConceptScore W4385955981C162317418 @default.
- W4385955981 hasConceptScore W4385955981C163952510 @default.
- W4385955981 hasConceptScore W4385955981C171056886 @default.
- W4385955981 hasConceptScore W4385955981C203014093 @default.