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- W4385955982 endingPage "100380" @default.
- W4385955982 startingPage "100380" @default.
- W4385955982 abstract "Cell lineages accumulate somatic mutations during organismal development, potentially leading to pathological states. The rate of somatic evolution within a cell population can vary due to multiple factors, including selection, a change in the mutation rate, or differences in the microenvironment. Here, we developed a statistical test called the Poisson Tree (PT) test to detect varying evolutionary rates among cell lineages, leveraging the phylogenetic signal of single-cell DNA sequencing (scDNA-seq) data. We applied the PT test to 24 healthy and cancer samples, rejecting a constant evolutionary rate in 11 out of 15 cancer and five out of nine healthy scDNA-seq datasets. In six cancer datasets, we identified subclonal mutations in known driver genes that could explain the rate accelerations of particular cancer lineages. Our findings demonstrate the efficacy of scDNA-seq for studying somatic evolution and suggest that cell lineages often evolve at different rates within cancer and healthy tissues." @default.
- W4385955982 created "2023-08-18" @default.
- W4385955982 creator A5018340662 @default.
- W4385955982 creator A5035497488 @default.
- W4385955982 creator A5038666930 @default.
- W4385955982 creator A5042649313 @default.
- W4385955982 creator A5055657759 @default.
- W4385955982 date "2023-09-01" @default.
- W4385955982 modified "2023-10-16" @default.
- W4385955982 title "Single-cell phylogenies reveal changes in the evolutionary rate within cancer and healthy tissues" @default.
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