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- W4385956623 abstract "<sec> <title>BACKGROUND</title> The southern India state of Kerala has among the highest proportion of older adults in its population in the country. An increase in chronic age-related diseases such as dementia is expected in the older Kerala population. Identifying older individuals early in the course of cognitive decline offers the best hope of introducing preventive measures early and planning management. However, the epidemiology and pathogenesis of predementia syndromes at the early stages of cognitive decline in older adults are not well established in India. </sec> <sec> <title>OBJECTIVE</title> The Kerala Einstein Study (KES) is a community-based cohort study that was established in 2008 and is based in the Kozhikode district in Kerala state. KES aims to establish risk factors and brain substrates of motoric cognitive risk syndrome (MCR), a predementia syndrome characterized by the presence of slow gait and subjective cognitive concerns in individuals without dementia or disability. This protocol describes the study design and procedures for this KES project. </sec> <sec> <title>METHODS</title> KES is proposing to enroll a sample of 1000 adults ≥60 years old from urban and rural areas in the Kozhikode district of Kerala state: 200 recruited in the previous phase of KES and 800 new participants to be recruited in this project. MCR is the cognitive phenotype of primary interest. The associations between previously established risk factors for dementia as well as novel risk factors (apathy and traumatic brain injury) and MCR will be examined in KES. Risk factor profiles for MCR will be compared between urban and rural residents as well as with individuals who meet the criteria for mild cognitive impairment (MCI). Cognitive and physical function, medical history and medications, sociodemographic characteristics, lifestyle patterns, and activities of daily living will be evaluated. Participants will also undergo magnetic resonance imaging and electrocardiogram investigations. Longitudinal follow-up is planned in a subset of participants as a prelude to future longitudinal studies. </sec> <sec> <title>RESULTS</title> KES (2R01AG039330-07) was funded by the US National Institutes of Health in September 2019 and received approval from the Indian Medical Council of Research to start the study in June 2021. We had recruited 433 new participants from urban and rural sites in Kozhikode as of May 2023: 41.1% (178/433) women, 67.7% (293/433) rural residents, and 13.4% (58/433) MCR cases. Enrollment is actively ongoing at all the KES recruitment sites. </sec> <sec> <title>CONCLUSIONS</title> KES will provide new insights into risk factors and brain substrates associated with MCR in India and will help guide future development of regionally specific preventive interventions for dementia. </sec> <sec> <title>INTERNATIONAL REGISTERED REPORT</title> DERR1-10.2196/49933 </sec>" @default.
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- W4385956623 date "2023-06-13" @default.
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- W4385956623 title "Epidemiology of Motoric Cognitive Risk Syndrome in the Kerala Einstein Study: Protocol for a Prospective Cohort Study (Preprint)" @default.
- W4385956623 cites W1507042971 @default.
- W4385956623 cites W1559206934 @default.
- W4385956623 cites W1606852336 @default.
- W4385956623 cites W1836202063 @default.
- W4385956623 cites W1966295452 @default.
- W4385956623 cites W1968480434 @default.
- W4385956623 cites W1972982304 @default.
- W4385956623 cites W1974941410 @default.
- W4385956623 cites W1977760944 @default.
- W4385956623 cites W1982921548 @default.
- W4385956623 cites W1984237483 @default.
- W4385956623 cites W1984267841 @default.
- W4385956623 cites W1984531700 @default.
- W4385956623 cites W1989711049 @default.
- W4385956623 cites W1997215897 @default.
- W4385956623 cites W1998518775 @default.
- W4385956623 cites W1999479542 @default.
- W4385956623 cites W2000445173 @default.
- W4385956623 cites W2017810434 @default.
- W4385956623 cites W2023937415 @default.
- W4385956623 cites W2025745331 @default.
- W4385956623 cites W2030064197 @default.
- W4385956623 cites W2031865452 @default.
- W4385956623 cites W2033427845 @default.
- W4385956623 cites W2040939183 @default.
- W4385956623 cites W2043705607 @default.
- W4385956623 cites W2044815056 @default.
- W4385956623 cites W2053149864 @default.
- W4385956623 cites W2068656021 @default.
- W4385956623 cites W2085529033 @default.
- W4385956623 cites W2096607451 @default.
- W4385956623 cites W2096657471 @default.
- W4385956623 cites W2102848905 @default.
- W4385956623 cites W2103547949 @default.
- W4385956623 cites W2105756219 @default.
- W4385956623 cites W2108948752 @default.
- W4385956623 cites W2110356839 @default.
- W4385956623 cites W2110546050 @default.
- W4385956623 cites W2111883921 @default.
- W4385956623 cites W2126136740 @default.
- W4385956623 cites W2139886607 @default.
- W4385956623 cites W2141189151 @default.
- W4385956623 cites W2146336531 @default.
- W4385956623 cites W2154116121 @default.
- W4385956623 cites W2155894782 @default.
- W4385956623 cites W2156655538 @default.
- W4385956623 cites W2157510525 @default.
- W4385956623 cites W2158742097 @default.
- W4385956623 cites W2161487213 @default.
- W4385956623 cites W2164059021 @default.
- W4385956623 cites W2166972767 @default.
- W4385956623 cites W2167291773 @default.
- W4385956623 cites W2169897728 @default.
- W4385956623 cites W2235459572 @default.
- W4385956623 cites W2281734071 @default.
- W4385956623 cites W2291320207 @default.
- W4385956623 cites W2292673340 @default.
- W4385956623 cites W2320441106 @default.
- W4385956623 cites W2339491854 @default.
- W4385956623 cites W2385081178 @default.
- W4385956623 cites W2460296584 @default.
- W4385956623 cites W2479195281 @default.
- W4385956623 cites W2572740724 @default.
- W4385956623 cites W2586759055 @default.
- W4385956623 cites W2606241194 @default.
- W4385956623 cites W2606481147 @default.
- W4385956623 cites W2831624879 @default.
- W4385956623 cites W2877135710 @default.
- W4385956623 cites W3004315912 @default.
- W4385956623 cites W3022542480 @default.
- W4385956623 cites W3119485853 @default.
- W4385956623 cites W3205783671 @default.
- W4385956623 cites W4205417274 @default.
- W4385956623 cites W4229625885 @default.
- W4385956623 cites W4240994521 @default.
- W4385956623 cites W4283031163 @default.