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• W4385957746 abstract "Pancreatic ductal adenocarcinoma (PDAC) is a highly devastating disease with a poor prognosis and growing incidence. In this study, we explored the potential roles of CDK1, CDK2, CDK4, and CDK6 in the progression of early-stage PDAC. Clinicopathologic and mRNA expression data and treatment information of 140 patients identified with stage I/II PDAC who underwent pancreaticoduodenectomy were obtained from the Cancer Genome Atlas data set. Our bioinformatic analysis showed that higher CDK1, CDK2, CDK4, or CDK6 expression was associated with a shorter median survival of the early-stage PDAC patients. Of note, in the low-proliferating pancreatic cancer group, CDKs expressions were significantly associated with proteins functioning in apoptosis, metastasis, immunity, or stemness. Among the low-proliferating PDAC, higher expression of CDK1 was associated with the shorter survival of patients, suggesting that CDK1 may regulate PDAC progression through cell cycleindependent mechanisms. Our experimental data showed that CDK1 knockdown/inhibition significantly suppressed the expression levels of AHR and POU5F1, two critical proteins functioning in cancer cell metastasis and stemness, in low-proliferating, but not in high-proliferating pancreatic cancer cells. In all, our study suggests that CDKs regulate PDAC progression not only through cell proliferation but also through apoptosis, metastasis, immunity, and stemness." @default.
• W4385957746 created "2023-08-18" @default.
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• W4385957746 date "2023-01-01" @default.
• W4385957746 modified "2023-10-17" @default.
• W4385957746 title "CDKs Functional Analysis in Low Proliferating Early-Stage Pancreatic Ductal Adenocarcinoma" @default.
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• W4385957746 doi "https://doi.org/10.26502/jbsb.5107060" @default.
• W4385957746 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37744402" @default.
• W4385957746 hasPublicationYear "2023" @default.
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