FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385968369> ?p ?o ?g. }

• W4385968369 abstract "Serpina3n/Serpina3 has been identified to be implicated in inflammatory diseases, but its role in interstitial cystitis/bladder pain syndrome (IC/BPS) remains unknown. Here, we aimed to reveal serpina3n/serpina3 role in IC/BPS in vivo and in vitro.The IC/BPS model in mice was induced by intraperitoneal injection of 150 mg/kg of cyclophosphamide (CYP). HE and toluidine blue staining were used for histology assessment. Serpina3n/serpina3 expression in the bladder tissues from IC/BPS patients and mouse models were determined by qPCR, immunohistochemistry and western blotting. XAV-939 treatment was applied to inhibit β-catenin activation. Serpina3 role in modulating the growth and apoptosis of HBlEpCs, a human primary bladder epithelial cell line, was assessed by CCK-8 and flow cytometry assays.Serpina3n/serpina3 expression was decreased in both human and mice bladder tissues with IC/BPS. Upregulation of serpina3n significantly alleviated CYP-induced bladder injury, with decreased mast cells and pro-inflammatory factor levels, including IL-1β, IL-6, and TNF-α, while increased IL-10 level. In addition, serpina3 overexpression inhibited the apoptosis of HBlEpCs, and increased cell growth. In mechanism, we found that serpina3 overexpression promoted the activation of wnt/β-catenin signaling. And, the inhibition of wnt/β-catenin signaling with XAV-939 abolished serpina3n/serpina3 role in protecting bladder tissues from CYP-induced cystitis, as well as inhibiting HBlEpC apoptosis.Serpina3n/serpina3 expression was decreased in IC/BPS. Overexpression of serpina3n could alleviate CYP-induced IC/BPS by activating the Wnt/β-catenin signal. This study may provide a new therapeutic strategy for IC/BPS." @default.
• W4385968369 created "2023-08-19" @default.
• W4385968369 creator A5003136423 @default.
• W4385968369 creator A5006186675 @default.
• W4385968369 creator A5009017304 @default.
• W4385968369 creator A5014085310 @default.
• W4385968369 creator A5014581301 @default.
• W4385968369 creator A5061463117 @default.
• W4385968369 creator A5065942429 @default.
• W4385968369 creator A5068621371 @default.
• W4385968369 creator A5082411167 @default.
• W4385968369 date "2023-08-18" @default.
• W4385968369 modified "2023-10-14" @default.
• W4385968369 title "Serpina3n/serpina3 alleviates cyclophosphamide-induced interstitial cystitis by activating the Wnt/β-catenin signal" @default.
• W4385968369 cites W1563535758 @default.
• W4385968369 cites W1579133082 @default.
• W4385968369 cites W1964052102 @default.
• W4385968369 cites W1979137100 @default.
• W4385968369 cites W1989727926 @default.
• W4385968369 cites W2002556755 @default.
• W4385968369 cites W2031448920 @default.
• W4385968369 cites W2054226501 @default.
• W4385968369 cites W2062116068 @default.
• W4385968369 cites W2067313526 @default.
• W4385968369 cites W2091205602 @default.
• W4385968369 cites W2096171021 @default.
• W4385968369 cites W2101096891 @default.
• W4385968369 cites W2112289496 @default.
• W4385968369 cites W2135665417 @default.
• W4385968369 cites W2163378821 @default.
• W4385968369 cites W2164594869 @default.
• W4385968369 cites W2280129392 @default.
• W4385968369 cites W2323679237 @default.
• W4385968369 cites W2369601073 @default.
• W4385968369 cites W2557377110 @default.
• W4385968369 cites W2805205940 @default.
• W4385968369 cites W2808818474 @default.
• W4385968369 cites W2897081143 @default.
• W4385968369 cites W2897338348 @default.
• W4385968369 cites W2902875209 @default.
• W4385968369 cites W2950763987 @default.
• W4385968369 cites W3014604613 @default.
• W4385968369 cites W3014626218 @default.
• W4385968369 cites W3081157373 @default.
• W4385968369 cites W3082053594 @default.
• W4385968369 cites W3092069524 @default.
• W4385968369 cites W3118951571 @default.
• W4385968369 cites W3156774813 @default.
• W4385968369 cites W3167913363 @default.
• W4385968369 cites W3194396869 @default.
• W4385968369 doi "https://doi.org/10.1007/s11255-023-03726-7" @default.
• W4385968369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37594700" @default.
• W4385968369 hasPublicationYear "2023" @default.
• W4385968369 type Work @default.
• W4385968369 citedByCount "0" @default.
• W4385968369 crossrefType "journal-article" @default.
• W4385968369 hasAuthorship W4385968369A5003136423 @default.
• W4385968369 hasAuthorship W4385968369A5006186675 @default.
• W4385968369 hasAuthorship W4385968369A5009017304 @default.
• W4385968369 hasAuthorship W4385968369A5014085310 @default.
• W4385968369 hasAuthorship W4385968369A5014581301 @default.
• W4385968369 hasAuthorship W4385968369A5061463117 @default.
• W4385968369 hasAuthorship W4385968369A5065942429 @default.
• W4385968369 hasAuthorship W4385968369A5068621371 @default.
• W4385968369 hasAuthorship W4385968369A5082411167 @default.
• W4385968369 hasBestOaLocation W43859683691 @default.
• W4385968369 hasConcept C126322002 @default.
• W4385968369 hasConcept C137620995 @default.
• W4385968369 hasConcept C142724271 @default.
• W4385968369 hasConcept C150903083 @default.
• W4385968369 hasConcept C190283241 @default.
• W4385968369 hasConcept C207001950 @default.
• W4385968369 hasConcept C2777540882 @default.
• W4385968369 hasConcept C2779762690 @default.
• W4385968369 hasConcept C2910041100 @default.
• W4385968369 hasConcept C30145163 @default.
• W4385968369 hasConcept C502942594 @default.
• W4385968369 hasConcept C55493867 @default.
• W4385968369 hasConcept C62478195 @default.
• W4385968369 hasConcept C71924100 @default.
• W4385968369 hasConcept C86803240 @default.
• W4385968369 hasConcept C95444343 @default.
• W4385968369 hasConceptScore W4385968369C126322002 @default.
• W4385968369 hasConceptScore W4385968369C137620995 @default.
• W4385968369 hasConceptScore W4385968369C142724271 @default.
• W4385968369 hasConceptScore W4385968369C150903083 @default.
• W4385968369 hasConceptScore W4385968369C190283241 @default.
• W4385968369 hasConceptScore W4385968369C207001950 @default.
• W4385968369 hasConceptScore W4385968369C2777540882 @default.
• W4385968369 hasConceptScore W4385968369C2779762690 @default.
• W4385968369 hasConceptScore W4385968369C2910041100 @default.
• W4385968369 hasConceptScore W4385968369C30145163 @default.
• W4385968369 hasConceptScore W4385968369C502942594 @default.
• W4385968369 hasConceptScore W4385968369C55493867 @default.
• W4385968369 hasConceptScore W4385968369C62478195 @default.
• W4385968369 hasConceptScore W4385968369C71924100 @default.
• W4385968369 hasConceptScore W4385968369C86803240 @default.
• W4385968369 hasConceptScore W4385968369C95444343 @default.
• W4385968369 hasLocation W43859683691 @default.
• W4385968369 hasLocation W43859683692 @default.

• next