FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385968482> ?p ?o ?g. }

• W4385968482 abstract "Upon DNA replication stress, cells utilize the post-replication repair pathway to repair single-stranded DNA and maintain genome integrity. Post-replication repair is divided into two branches: error-prone translesion synthesis, signaled by PCNA mono-ubiquitination, and error-free template switching, signaled by PCNA poly-ubiquitination. In Saccharomyces cerevisiae, Rad5 is involved in both branches of repair during DNA replication stress. When the PCNA poly-ubiquitination function of Rad5 is disrupted, Rad5 recruits translesion synthesis polymerases to stalled replication forks, resulting in mutagenic repair. Details of how mutagenic repair is carried out, as well as the relationship between Rad5-mediated mutagenic repair and the canonical PCNA-mediated mutagenic repair, remain to be understood. We find that Rad5-mediated mutagenic repair requires the translesion synthesis polymerase ζ but does not require other yeast translesion polymerase activities. Furthermore, we show that Rad5-mediated mutagenic repair is independent of PCNA binding by Rev1 and so is separable from canonical mutagenic repair. In the absence of error-free template switching, both modes of mutagenic repair contribute additively to replication stress response in a replication timing-independent manner. Cellular contexts where error-free template switching is compromised are not simply laboratory phenomena, as we find that a natural variant in RAD5 is defective in PCNA poly-ubiquitination and therefore defective in error-free repair, resulting in Rad5- and PCNA-mediated mutagenic repair. Our results highlight the importance of Rad5 in regulating spontaneous mutagenesis and genetic diversity in S. cerevisiae through different modes of post-replication repair." @default.
• W4385968482 created "2023-08-19" @default.
• W4385968482 creator A5013020701 @default.
• W4385968482 creator A5037801746 @default.
• W4385968482 creator A5069152548 @default.
• W4385968482 date "2023-08-18" @default.
• W4385968482 modified "2023-10-06" @default.
• W4385968482 title "Two independent DNA repair pathways cause mutagenesis in template switching deficient <i>Saccharomyces cerevisiae</i>" @default.
• W4385968482 cites W1952865218 @default.
• W4385968482 cites W1967758986 @default.
• W4385968482 cites W1974425687 @default.
• W4385968482 cites W1977186059 @default.
• W4385968482 cites W1990906479 @default.
• W4385968482 cites W1993230731 @default.
• W4385968482 cites W1996443829 @default.
• W4385968482 cites W2009430092 @default.
• W4385968482 cites W2021698403 @default.
• W4385968482 cites W2022148699 @default.
• W4385968482 cites W2040860750 @default.
• W4385968482 cites W2042793731 @default.
• W4385968482 cites W2054918042 @default.
• W4385968482 cites W2069485100 @default.
• W4385968482 cites W2069738344 @default.
• W4385968482 cites W2069894032 @default.
• W4385968482 cites W2074655992 @default.
• W4385968482 cites W2076722802 @default.
• W4385968482 cites W2079266876 @default.
• W4385968482 cites W2079818352 @default.
• W4385968482 cites W2080574942 @default.
• W4385968482 cites W2085021706 @default.
• W4385968482 cites W2089855871 @default.
• W4385968482 cites W2092869952 @default.
• W4385968482 cites W2098418459 @default.
• W4385968482 cites W2101784201 @default.
• W4385968482 cites W2103830174 @default.
• W4385968482 cites W2110451776 @default.
• W4385968482 cites W2110668915 @default.
• W4385968482 cites W2119301405 @default.
• W4385968482 cites W2130937328 @default.
• W4385968482 cites W2131510695 @default.
• W4385968482 cites W2131778464 @default.
• W4385968482 cites W2135858046 @default.
• W4385968482 cites W2144072604 @default.
• W4385968482 cites W2146503498 @default.
• W4385968482 cites W2148123849 @default.
• W4385968482 cites W2151533829 @default.
• W4385968482 cites W2152999910 @default.
• W4385968482 cites W2164123369 @default.
• W4385968482 cites W2164408923 @default.
• W4385968482 cites W2168017683 @default.
• W4385968482 cites W2171540539 @default.
• W4385968482 cites W2272000266 @default.
• W4385968482 cites W2308946929 @default.
• W4385968482 cites W2327611812 @default.
• W4385968482 cites W2402345552 @default.
• W4385968482 cites W2470508052 @default.
• W4385968482 cites W2537411615 @default.
• W4385968482 cites W2586664616 @default.
• W4385968482 cites W2765753861 @default.
• W4385968482 cites W2785784674 @default.
• W4385968482 cites W2791448060 @default.
• W4385968482 cites W2806417234 @default.
• W4385968482 cites W2811106513 @default.
• W4385968482 cites W2913385233 @default.
• W4385968482 cites W2950354887 @default.
• W4385968482 cites W2979898694 @default.
• W4385968482 cites W3039550460 @default.
• W4385968482 cites W3041766988 @default.
• W4385968482 cites W3080408150 @default.
• W4385968482 cites W3113081857 @default.
• W4385968482 cites W3200797520 @default.
• W4385968482 cites W3203739989 @default.
• W4385968482 cites W4206085595 @default.
• W4385968482 cites W4206110660 @default.
• W4385968482 cites W4283012954 @default.
• W4385968482 cites W4285021881 @default.
• W4385968482 doi "https://doi.org/10.1093/genetics/iyad153" @default.
• W4385968482 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37594077" @default.
• W4385968482 hasPublicationYear "2023" @default.
• W4385968482 type Work @default.
• W4385968482 citedByCount "0" @default.
• W4385968482 crossrefType "journal-article" @default.
• W4385968482 hasAuthorship W4385968482A5013020701 @default.
• W4385968482 hasAuthorship W4385968482A5037801746 @default.
• W4385968482 hasAuthorship W4385968482A5069152548 @default.
• W4385968482 hasBestOaLocation W43859684822 @default.
• W4385968482 hasConcept C104317684 @default.
• W4385968482 hasConcept C104451858 @default.
• W4385968482 hasConcept C113271649 @default.
• W4385968482 hasConcept C134935766 @default.
• W4385968482 hasConcept C143425029 @default.
• W4385968482 hasConcept C153911025 @default.
• W4385968482 hasConcept C156719811 @default.
• W4385968482 hasConcept C16318435 @default.
• W4385968482 hasConcept C23458808 @default.
• W4385968482 hasConcept C2756471 @default.
• W4385968482 hasConcept C2777576037 @default.
• W4385968482 hasConcept C34688535 @default.
• W4385968482 hasConcept C49105822 @default.
• W4385968482 hasConcept C501734568 @default.

• next