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• W4385969239 abstract "Nicotine cessation leads to anxiety and depression.The suitability of the zebrafish model of anhedonia using reserpine and fluoxetine was evaluated. Fluoxetine was also used to reduce nicotine withdrawal-induced anhedonic state.Zebrafish were exposed to reserpine (40 mg/l) and then to fluoxetine (0.1 mg/l) for 1 week. Anhedonia was evaluated in the Novel Tank Diving and Compartment Preference tests. Another group was exposed to nicotine (1 mg/l/2 weeks) and then exposed to fluoxetine. Anxiety and anhedonia were evaluated 2-60 days after. Tyrosine hydroxylase (TH) immunoreactivity and microglial morphology (labelled by 4C4 monoclonal antibody) in the parvocellular pretectal nucleus (PPN), dorsal part, and of calcitonin gene-related peptide (CGRP) in the hypothalamus were also analysed.Less time in the top and increased latency to the top in reserpine compared to a drug-free group was found. Fluoxetine rescued reserpine-induced the reduced time in the top. Seven and 30 days after nicotine withdrawal more time in the bottom and similar time in the Compartment Preference test, rescued by fluoxetine, were shown. In the PPN, 30-day withdrawal induced an increase in TH immunoreactivity, but fluoxetine induced a further significant increase. No changes in PPN microglia morphology and hypothalamic CGRP were detected.Our findings validate the suitability of the zebrafish model of anhedonia using the reserpine-induced depression-like behaviour and the predictivity using fluoxetine. Fluoxetine rescued nicotine withdrawal-induced anhedonic state, opening the possibility to screen new drugs to alleviate anxiety and depression in smokers during abstinence." @default.
• W4385969239 created "2023-08-19" @default.
• W4385969239 creator A5043092838 @default.
• W4385969239 creator A5053529456 @default.
• W4385969239 creator A5061203019 @default.
• W4385969239 creator A5076516536 @default.
• W4385969239 creator A5092839048 @default.
• W4385969239 date "2023-08-18" @default.
• W4385969239 modified "2023-10-06" @default.
• W4385969239 title "Fluoxetine rescues the depressive-like behaviour induced by reserpine and the altered emotional behaviour induced by nicotine withdrawal in zebrafish: Involvement of tyrosine hydroxylase" @default.
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• W4385969239 doi "https://doi.org/10.1177/02698811231191103" @default.
• W4385969239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37593958" @default.
• W4385969239 hasPublicationYear "2023" @default.
• W4385969239 type Work @default.
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• W4385969239 hasAuthorship W4385969239A5053529456 @default.

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