FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385969293> ?p ?o ?g. }

• W4385969293 abstract "A large body of literature has highlighted the significance of the corticotropin-releasing factor (CRF) system in the regulation of neuropsychiatric diseases. Anxiety disorders are among the most common neuropsychiatric disorders. An increasing number of studies have demonstrated that the CRF family mediates and regulates the development and maintenance of anxiety. Thus, the CRF family is considered to be a potential target for the treatment of anxiety disorders. The prefrontal cortex (PFC) plays a role in the occurrence and development of anxiety, and both CRF and CRF-R1 are widely expressed in the PFC. This paper begins by reviewing CRF-related signaling pathways and their different roles in anxiety and related processes. Then, the role of the CRF system in other neuropsychiatric diseases is reviewed and the potential role of PFC CRF signaling in the regulation of anxiety disorders is discussed. Although other signaling pathways are potentially involved in the process of anxiety, CRF in the PFC primarily modulates anxiety disorders through the activation of corticotropin-releasing factor type1 receptors (CRF-R1) and the excitation of the cAMP/PKA signaling pathway. Moreover, the main signaling pathways of CRF involved in sex differentiation in the PFC appear to be different. In summary, this review suggests that the CRF system in the PFC plays a critical role in the occurrence of anxiety. Thus, CRF signaling is of great significance as a potential target for the treatment of stress-related disorders in the future." @default.
• W4385969293 created "2023-08-19" @default.
• W4385969293 creator A5075115724 @default.
• W4385969293 creator A5075906710 @default.
• W4385969293 date "2023-08-18" @default.
• W4385969293 modified "2023-10-09" @default.
• W4385969293 title "Corticotropin‐releasing factor signaling and its potential role in the prefrontal cortex‐dependent regulation of anxiety" @default.
• W4385969293 cites W1133363097 @default.
• W4385969293 cites W14396242 @default.
• W4385969293 cites W1495277562 @default.
• W4385969293 cites W1496961660 @default.
• W4385969293 cites W1540969441 @default.
• W4385969293 cites W1548760166 @default.
• W4385969293 cites W1550063945 @default.
• W4385969293 cites W1572525448 @default.
• W4385969293 cites W1681520334 @default.
• W4385969293 cites W1703928389 @default.
• W4385969293 cites W1744121855 @default.
• W4385969293 cites W186421534 @default.
• W4385969293 cites W1897149844 @default.
• W4385969293 cites W1966613107 @default.
• W4385969293 cites W1969800465 @default.
• W4385969293 cites W1970871255 @default.
• W4385969293 cites W1974253960 @default.
• W4385969293 cites W1976016445 @default.
• W4385969293 cites W1978000199 @default.
• W4385969293 cites W1984437233 @default.
• W4385969293 cites W1985207474 @default.
• W4385969293 cites W1985387196 @default.
• W4385969293 cites W1985694975 @default.
• W4385969293 cites W1986576876 @default.
• W4385969293 cites W1986984420 @default.
• W4385969293 cites W1987448598 @default.
• W4385969293 cites W1992816731 @default.
• W4385969293 cites W1992828586 @default.
• W4385969293 cites W1994134409 @default.
• W4385969293 cites W1998821779 @default.
• W4385969293 cites W1999157161 @default.
• W4385969293 cites W2003250723 @default.
• W4385969293 cites W2003654636 @default.
• W4385969293 cites W2003973869 @default.
• W4385969293 cites W2006472411 @default.
• W4385969293 cites W2008860212 @default.
• W4385969293 cites W2012416101 @default.
• W4385969293 cites W2012438450 @default.
• W4385969293 cites W2015816977 @default.
• W4385969293 cites W2017168736 @default.
• W4385969293 cites W2021464806 @default.
• W4385969293 cites W2023507956 @default.
• W4385969293 cites W2025253720 @default.
• W4385969293 cites W2027580766 @default.
• W4385969293 cites W2030611621 @default.
• W4385969293 cites W2031048563 @default.
• W4385969293 cites W2031441539 @default.
• W4385969293 cites W2032538117 @default.
• W4385969293 cites W2033932995 @default.
• W4385969293 cites W2035240522 @default.
• W4385969293 cites W2037593319 @default.
• W4385969293 cites W2039370934 @default.
• W4385969293 cites W2039893634 @default.
• W4385969293 cites W2043525975 @default.
• W4385969293 cites W2044331640 @default.
• W4385969293 cites W2050120242 @default.
• W4385969293 cites W2051089361 @default.
• W4385969293 cites W2059074079 @default.
• W4385969293 cites W2060041930 @default.
• W4385969293 cites W2060772645 @default.
• W4385969293 cites W2062682953 @default.
• W4385969293 cites W2062976494 @default.
• W4385969293 cites W2063360806 @default.
• W4385969293 cites W2068818952 @default.
• W4385969293 cites W2070065061 @default.
• W4385969293 cites W2071256705 @default.
• W4385969293 cites W2071358231 @default.
• W4385969293 cites W2073278098 @default.
• W4385969293 cites W2073964374 @default.
• W4385969293 cites W2075547760 @default.
• W4385969293 cites W2079283607 @default.
• W4385969293 cites W2080244900 @default.
• W4385969293 cites W2084407386 @default.
• W4385969293 cites W2084896388 @default.
• W4385969293 cites W2090779643 @default.
• W4385969293 cites W2090997737 @default.
• W4385969293 cites W2092829453 @default.
• W4385969293 cites W2095036452 @default.
• W4385969293 cites W2098001295 @default.
• W4385969293 cites W2110748165 @default.
• W4385969293 cites W2115449312 @default.
• W4385969293 cites W2116629441 @default.
• W4385969293 cites W2118238128 @default.
• W4385969293 cites W2119398013 @default.
• W4385969293 cites W2129752568 @default.
• W4385969293 cites W2130189270 @default.
• W4385969293 cites W2134120617 @default.
• W4385969293 cites W2143742981 @default.
• W4385969293 cites W2148133748 @default.
• W4385969293 cites W2152885509 @default.
• W4385969293 cites W2155331383 @default.
• W4385969293 cites W2156736899 @default.
• W4385969293 cites W2157103026 @default.

• next