FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385969307> ?p ?o ?g. }

• W4385969307 abstract "The current evidence demonstrates that mesenchymal stem cells (MSCs) hold therapeutic potential for ischemic stroke. However, it remains unclear how changes in the secretion of MSC cytokines following the overexpression of heme oxygenase-1 (HO-1) impact excessive inflammatory activation in a mouse ischemic stroke model. This study investigated this aspect and provided further insights.The middle cerebral artery occlusion (MCAO) mouse model was established, and subsequent injections of MSC, MSCHO-1 , or PBS solutions of equal volume were administered via the mice's tail vein. Histopathological analysis was conducted on Days 3 and 28 post-MCAO to observe morphological changes in brain slices. mRNA expression levels of various factors, including IL-1β, IL-6, IL-17, TNF-α, IL-1Ra, IL-4, IL-10, TGF-β, were quantified. The effects of MSCHO-1 treatment on neurons, microglia, and astrocytes were observed using immunofluorescence after transplantation. The polarization direction of macrophages/microglia was also detected using flow cytometry.The results showed that the expression of anti-inflammatory factors in the MSCHO-1 group increased while that of pro-inflammatory factors decreased. Small animal fluorescence studies and immunofluorescence assays showed that the homing function of MSCsHO-1 was unaffected, leading to a substantial accumulation of MSCsHO-1 in the cerebral ischemic region within 24 h. Neurons were less damaged, activation and proliferation of microglia were reduced, and polarization of microglia to the M2 type increased after MSCHO-1 transplantation. Furthermore, after transplantation of MSCsHO-1 , the mortality of mice decreased, and motor function improved significantly.The findings indicate that MSCs overexpressing HO-1 exhibited significant therapeutic effects against hyper-inflammatory injury after stroke in mice, ultimately promoting recovery after ischemic stroke." @default.
• W4385969307 created "2023-08-19" @default.
• W4385969307 creator A5011571935 @default.
• W4385969307 creator A5021548031 @default.
• W4385969307 creator A5028433300 @default.
• W4385969307 creator A5036681335 @default.
• W4385969307 creator A5037781038 @default.
• W4385969307 creator A5039366205 @default.
• W4385969307 creator A5047093158 @default.
• W4385969307 creator A5068464851 @default.
• W4385969307 creator A5069725010 @default.
• W4385969307 creator A5078803466 @default.
• W4385969307 creator A5080401376 @default.
• W4385969307 date "2023-08-17" @default.
• W4385969307 modified "2023-10-18" @default.
• W4385969307 title "Human umbilical cord derived mesenchymal stem cells overexpressing <scp>HO</scp>‐1 attenuate neural injury and enhance functional recovery by inhibiting inflammation in stroke mice" @default.
• W4385969307 cites W1971442835 @default.
• W4385969307 cites W2014582736 @default.
• W4385969307 cites W2073523882 @default.
• W4385969307 cites W2084838884 @default.
• W4385969307 cites W2114303594 @default.
• W4385969307 cites W2114570899 @default.
• W4385969307 cites W2298832169 @default.
• W4385969307 cites W2402473392 @default.
• W4385969307 cites W2567501064 @default.
• W4385969307 cites W2741222377 @default.
• W4385969307 cites W2750520189 @default.
• W4385969307 cites W2769845883 @default.
• W4385969307 cites W2788731808 @default.
• W4385969307 cites W2808158796 @default.
• W4385969307 cites W2809264303 @default.
• W4385969307 cites W2902609577 @default.
• W4385969307 cites W2924773895 @default.
• W4385969307 cites W2955840631 @default.
• W4385969307 cites W2963134140 @default.
• W4385969307 cites W2997493384 @default.
• W4385969307 cites W3019436661 @default.
• W4385969307 cites W3026555657 @default.
• W4385969307 cites W3048695591 @default.
• W4385969307 cites W3127407724 @default.
• W4385969307 cites W3132226537 @default.
• W4385969307 cites W3133969007 @default.
• W4385969307 cites W3165026729 @default.
• W4385969307 cites W3169111193 @default.
• W4385969307 cites W3179241079 @default.
• W4385969307 cites W3189693479 @default.
• W4385969307 cites W3213753238 @default.
• W4385969307 cites W4200406116 @default.
• W4385969307 cites W4205679663 @default.
• W4385969307 cites W4220758756 @default.
• W4385969307 cites W4220790273 @default.
• W4385969307 cites W4288679642 @default.
• W4385969307 cites W4291814921 @default.
• W4385969307 cites W4295864906 @default.
• W4385969307 cites W4296048600 @default.
• W4385969307 cites W4304778191 @default.
• W4385969307 cites W4306737653 @default.
• W4385969307 cites W4322761388 @default.
• W4385969307 doi "https://doi.org/10.1111/cns.14412" @default.
• W4385969307 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37592866" @default.
• W4385969307 hasPublicationYear "2023" @default.
• W4385969307 type Work @default.
• W4385969307 citedByCount "0" @default.
• W4385969307 crossrefType "journal-article" @default.
• W4385969307 hasAuthorship W4385969307A5011571935 @default.
• W4385969307 hasAuthorship W4385969307A5021548031 @default.
• W4385969307 hasAuthorship W4385969307A5028433300 @default.
• W4385969307 hasAuthorship W4385969307A5036681335 @default.
• W4385969307 hasAuthorship W4385969307A5037781038 @default.
• W4385969307 hasAuthorship W4385969307A5039366205 @default.
• W4385969307 hasAuthorship W4385969307A5047093158 @default.
• W4385969307 hasAuthorship W4385969307A5068464851 @default.
• W4385969307 hasAuthorship W4385969307A5069725010 @default.
• W4385969307 hasAuthorship W4385969307A5078803466 @default.
• W4385969307 hasAuthorship W4385969307A5080401376 @default.
• W4385969307 hasBestOaLocation W43859693071 @default.
• W4385969307 hasConcept C126322002 @default.
• W4385969307 hasConcept C142724271 @default.
• W4385969307 hasConcept C151872237 @default.
• W4385969307 hasConcept C159654299 @default.
• W4385969307 hasConcept C18903297 @default.
• W4385969307 hasConcept C198826908 @default.
• W4385969307 hasConcept C203014093 @default.
• W4385969307 hasConcept C2776914184 @default.
• W4385969307 hasConcept C2778236600 @default.
• W4385969307 hasConcept C2779830541 @default.
• W4385969307 hasConcept C2911091166 @default.
• W4385969307 hasConcept C553184892 @default.
• W4385969307 hasConcept C71924100 @default.
• W4385969307 hasConcept C86803240 @default.
• W4385969307 hasConceptScore W4385969307C126322002 @default.
• W4385969307 hasConceptScore W4385969307C142724271 @default.
• W4385969307 hasConceptScore W4385969307C151872237 @default.
• W4385969307 hasConceptScore W4385969307C159654299 @default.
• W4385969307 hasConceptScore W4385969307C18903297 @default.
• W4385969307 hasConceptScore W4385969307C198826908 @default.
• W4385969307 hasConceptScore W4385969307C203014093 @default.
• W4385969307 hasConceptScore W4385969307C2776914184 @default.
• W4385969307 hasConceptScore W4385969307C2778236600 @default.
• W4385969307 hasConceptScore W4385969307C2779830541 @default.

• next