FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385970840> ?p ?o ?g. }

• W4385970840 abstract "KMT2A-rearranged (KMT2A-r) B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is widely recognized as a high-risk leukemia in both children and adults. However, there is a paucity of data on adults treated in recent protocols and the optimal treatment strategy for these patients is still a matter of debate. In this study, we set out to refine the prognosis of adult KMT2A-r BCP-ALL treated with modern chemotherapy regimen and investigate the prognostic impact of co-mutations and minimal residual disease (MRD). Of 1091 adult patients with Philadelphia-negative BCP-ALL enrolled in three consecutive GRAALL trials, 141 (12.9%) had KMT2A-r, with 5-year cumulative incidence of relapse (CIR) and overall survival (OS) rates of 40.7% and 53.3%, respectively. Molecular profiling highlighted a low mutational burden in this subtype, reminiscent of infant BCP-ALL. However, the presence of TP53 and/or IKZF1 alterations defined a subset of patients with significantly poorer CIR (69.3% vs 36.2%, p=0.001) and OS (28.1% vs 60.7%, p=0.006). We next analyzed the prognostic implication of MRD measured after induction and first consolidation, using both immunoglobulin (IG)/T-cell receptor (TR) rearrangements and KMT2A genomic fusion as markers. In approximately one third of patients, IG/TR rearrangements were absent or displayed clonal evolution during the disease course, compromising MRD monitoring. By contrast, KMT2A-based MRD was highly reliable and was strongly associated with outcome, with early good responders having an excellent outcome (3-year CIR 7.1% and OS 92.9%). Altogether, our study reveals striking heterogeneity in outcomes within adults with KMT2A-r BCP-ALL and provides new biomarkers to guide risk-based therapeutic stratification." @default.
• W4385970840 created "2023-08-19" @default.
• W4385970840 creator A5000436961 @default.
• W4385970840 creator A5004066423 @default.
• W4385970840 creator A5006990604 @default.
• W4385970840 creator A5007895303 @default.
• W4385970840 creator A5009193536 @default.
• W4385970840 creator A5009884108 @default.
• W4385970840 creator A5010632074 @default.
• W4385970840 creator A5018514641 @default.
• W4385970840 creator A5023619034 @default.
• W4385970840 creator A5025168447 @default.
• W4385970840 creator A5033797515 @default.
• W4385970840 creator A5034355848 @default.
• W4385970840 creator A5037286573 @default.
• W4385970840 creator A5044033798 @default.
• W4385970840 creator A5045751060 @default.
• W4385970840 creator A5046742745 @default.
• W4385970840 creator A5049438446 @default.
• W4385970840 creator A5049919069 @default.
• W4385970840 creator A5053681765 @default.
• W4385970840 creator A5055524428 @default.
• W4385970840 creator A5059340186 @default.
• W4385970840 creator A5061934865 @default.
• W4385970840 creator A5062808434 @default.
• W4385970840 creator A5064103067 @default.
• W4385970840 creator A5073015935 @default.
• W4385970840 creator A5074192291 @default.
• W4385970840 creator A5076973611 @default.
• W4385970840 creator A5081933349 @default.
• W4385970840 creator A5083101824 @default.
• W4385970840 creator A5085953785 @default.
• W4385970840 creator A5086985283 @default.
• W4385970840 creator A5092804687 @default.
• W4385970840 date "2023-08-18" @default.
• W4385970840 modified "2023-10-18" @default.
• W4385970840 title "Genetic alterations and MRD refine risk assessment within <i>KMT2A</i>-rearranged B-cell precursor ALL in adult: a GRAALL study" @default.
• W4385970840 doi "https://doi.org/10.1182/blood.2023021501" @default.
• W4385970840 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37595275" @default.
• W4385970840 hasPublicationYear "2023" @default.
• W4385970840 type Work @default.
• W4385970840 citedByCount "0" @default.
• W4385970840 crossrefType "journal-article" @default.
• W4385970840 hasAuthorship W4385970840A5000436961 @default.
• W4385970840 hasAuthorship W4385970840A5004066423 @default.
• W4385970840 hasAuthorship W4385970840A5006990604 @default.
• W4385970840 hasAuthorship W4385970840A5007895303 @default.
• W4385970840 hasAuthorship W4385970840A5009193536 @default.
• W4385970840 hasAuthorship W4385970840A5009884108 @default.
• W4385970840 hasAuthorship W4385970840A5010632074 @default.
• W4385970840 hasAuthorship W4385970840A5018514641 @default.
• W4385970840 hasAuthorship W4385970840A5023619034 @default.
• W4385970840 hasAuthorship W4385970840A5025168447 @default.
• W4385970840 hasAuthorship W4385970840A5033797515 @default.
• W4385970840 hasAuthorship W4385970840A5034355848 @default.
• W4385970840 hasAuthorship W4385970840A5037286573 @default.
• W4385970840 hasAuthorship W4385970840A5044033798 @default.
• W4385970840 hasAuthorship W4385970840A5045751060 @default.
• W4385970840 hasAuthorship W4385970840A5046742745 @default.
• W4385970840 hasAuthorship W4385970840A5049438446 @default.
• W4385970840 hasAuthorship W4385970840A5049919069 @default.
• W4385970840 hasAuthorship W4385970840A5053681765 @default.
• W4385970840 hasAuthorship W4385970840A5055524428 @default.
• W4385970840 hasAuthorship W4385970840A5059340186 @default.
• W4385970840 hasAuthorship W4385970840A5061934865 @default.
• W4385970840 hasAuthorship W4385970840A5062808434 @default.
• W4385970840 hasAuthorship W4385970840A5064103067 @default.
• W4385970840 hasAuthorship W4385970840A5073015935 @default.
• W4385970840 hasAuthorship W4385970840A5074192291 @default.
• W4385970840 hasAuthorship W4385970840A5076973611 @default.
• W4385970840 hasAuthorship W4385970840A5081933349 @default.
• W4385970840 hasAuthorship W4385970840A5083101824 @default.
• W4385970840 hasAuthorship W4385970840A5085953785 @default.
• W4385970840 hasAuthorship W4385970840A5086985283 @default.
• W4385970840 hasAuthorship W4385970840A5092804687 @default.
• W4385970840 hasConcept C126322002 @default.
• W4385970840 hasConcept C143998085 @default.
• W4385970840 hasConcept C203014093 @default.
• W4385970840 hasConcept C2776694085 @default.
• W4385970840 hasConcept C2778336483 @default.
• W4385970840 hasConcept C2778461978 @default.
• W4385970840 hasConcept C2779823535 @default.
• W4385970840 hasConcept C2781413609 @default.
• W4385970840 hasConcept C71924100 @default.
• W4385970840 hasConcept C72563966 @default.
• W4385970840 hasConcept C88879693 @default.
• W4385970840 hasConceptScore W4385970840C126322002 @default.
• W4385970840 hasConceptScore W4385970840C143998085 @default.
• W4385970840 hasConceptScore W4385970840C203014093 @default.
• W4385970840 hasConceptScore W4385970840C2776694085 @default.
• W4385970840 hasConceptScore W4385970840C2778336483 @default.
• W4385970840 hasConceptScore W4385970840C2778461978 @default.
• W4385970840 hasConceptScore W4385970840C2779823535 @default.
• W4385970840 hasConceptScore W4385970840C2781413609 @default.
• W4385970840 hasConceptScore W4385970840C71924100 @default.
• W4385970840 hasConceptScore W4385970840C72563966 @default.
• W4385970840 hasConceptScore W4385970840C88879693 @default.
• W4385970840 hasLocation W43859708401 @default.
• W4385970840 hasLocation W43859708402 @default.
• W4385970840 hasOpenAccess W4385970840 @default.

• next