Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385971952> ?p ?o ?g. }
- W4385971952 endingPage "e937" @default.
- W4385971952 startingPage "e937" @default.
- W4385971952 abstract "Conventional therapies for acute myeloid leukemia (AML) are characterized by high rates of relapse, severe toxicities, and poor overall survival rates. Thus, the development of new therapeutic strategies is crucial for improving the survival and quality of life of AML patients. CD19-directed chimeric antigen receptor (CAR) T-cell immunotherapy has been extremely successful in the treatment of B-cell acute lymphoid leukemia and several mature B-cell lymphomas. However, the use of CAR T-cell therapy for AML is currently prevented due to the lack of a myeloid equivalent to CD19, as currently known cell surface targets on leukemic blasts are also expressed on healthy hematopoietic stem and progenitor cells as well as their progeny. In addition, the immunosuppressive tumor microenvironment has a dampening effect on the antitumor activity of CAR-T cells. Here, we review the therapeutic challenges limiting the use of CAR T-cell therapy for AML and discuss promising novel strategies to overcome them." @default.
- W4385971952 created "2023-08-19" @default.
- W4385971952 creator A5011582886 @default.
- W4385971952 creator A5032149122 @default.
- W4385971952 creator A5071405091 @default.
- W4385971952 creator A5071534196 @default.
- W4385971952 creator A5075216811 @default.
- W4385971952 creator A5083636221 @default.
- W4385971952 creator A5086564584 @default.
- W4385971952 creator A5092659938 @default.
- W4385971952 date "2023-08-18" @default.
- W4385971952 modified "2023-09-25" @default.
- W4385971952 title "CAR-T in the Treatment of Acute Myeloid Leukemia: Barriers and How to Overcome Them" @default.
- W4385971952 cites W1522048276 @default.
- W4385971952 cites W1973765711 @default.
- W4385971952 cites W1975889870 @default.
- W4385971952 cites W2010607826 @default.
- W4385971952 cites W2025300117 @default.
- W4385971952 cites W2026252733 @default.
- W4385971952 cites W2052328656 @default.
- W4385971952 cites W2082708772 @default.
- W4385971952 cites W2083730819 @default.
- W4385971952 cites W2087671080 @default.
- W4385971952 cites W2097175022 @default.
- W4385971952 cites W2104597364 @default.
- W4385971952 cites W2113802879 @default.
- W4385971952 cites W2115817713 @default.
- W4385971952 cites W2132693111 @default.
- W4385971952 cites W2138494474 @default.
- W4385971952 cites W2144186438 @default.
- W4385971952 cites W2158485828 @default.
- W4385971952 cites W2253938658 @default.
- W4385971952 cites W2340435799 @default.
- W4385971952 cites W2543973826 @default.
- W4385971952 cites W2560318964 @default.
- W4385971952 cites W2584913109 @default.
- W4385971952 cites W2593086395 @default.
- W4385971952 cites W2766879149 @default.
- W4385971952 cites W2774484554 @default.
- W4385971952 cites W2787301955 @default.
- W4385971952 cites W2788008397 @default.
- W4385971952 cites W2792588868 @default.
- W4385971952 cites W2805058565 @default.
- W4385971952 cites W2807706866 @default.
- W4385971952 cites W2889359744 @default.
- W4385971952 cites W2890642520 @default.
- W4385971952 cites W2894996603 @default.
- W4385971952 cites W2900136343 @default.
- W4385971952 cites W2903169068 @default.
- W4385971952 cites W2903615768 @default.
- W4385971952 cites W2915597716 @default.
- W4385971952 cites W2919051790 @default.
- W4385971952 cites W2921180030 @default.
- W4385971952 cites W2942562472 @default.
- W4385971952 cites W2942621614 @default.
- W4385971952 cites W2947751606 @default.
- W4385971952 cites W2952529368 @default.
- W4385971952 cites W2953265626 @default.
- W4385971952 cites W2956092422 @default.
- W4385971952 cites W2959127920 @default.
- W4385971952 cites W2969586911 @default.
- W4385971952 cites W2973443369 @default.
- W4385971952 cites W2977304256 @default.
- W4385971952 cites W2978438841 @default.
- W4385971952 cites W2979495513 @default.
- W4385971952 cites W2980542859 @default.
- W4385971952 cites W2989449197 @default.
- W4385971952 cites W2999212986 @default.
- W4385971952 cites W3002073720 @default.
- W4385971952 cites W3004688556 @default.
- W4385971952 cites W3006367172 @default.
- W4385971952 cites W3010217167 @default.
- W4385971952 cites W3022057969 @default.
- W4385971952 cites W3022543485 @default.
- W4385971952 cites W3037522076 @default.
- W4385971952 cites W3038790873 @default.
- W4385971952 cites W3045778847 @default.
- W4385971952 cites W3046771604 @default.
- W4385971952 cites W3092603045 @default.
- W4385971952 cites W3096785749 @default.
- W4385971952 cites W3120439274 @default.
- W4385971952 cites W3124472806 @default.
- W4385971952 cites W3135442493 @default.
- W4385971952 cites W3137893730 @default.
- W4385971952 cites W3154903133 @default.
- W4385971952 cites W3159888487 @default.
- W4385971952 cites W3162374648 @default.
- W4385971952 cites W3184405876 @default.
- W4385971952 cites W3200480347 @default.
- W4385971952 cites W3206099201 @default.
- W4385971952 cites W4200205224 @default.
- W4385971952 cites W4200540015 @default.
- W4385971952 cites W4206626897 @default.
- W4385971952 cites W4214907529 @default.
- W4385971952 cites W4223507706 @default.
- W4385971952 cites W4224324126 @default.
- W4385971952 cites W4226460098 @default.
- W4385971952 cites W4281761026 @default.