FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385972018> ?p ?o ?g. }

• W4385972018 abstract "ABSTRACT Macrophages play a crucial role in eliminating respiratory pathogens. Both pulmonary resident alveolar macrophages (AMs) and recruited macrophages contribute to detecting, responding to, and resolving infections in the lungs. Despite their distinct functions, it remains unclear how these macrophage subsets regulate their responses to infection, including how activation by the cytokine IFNγ is regulated. This shortcoming prevents the development of therapeutics that effectively target distinct lung macrophage populations without exacerbating inflammation. We aimed to better understand the transcriptional regulation of resting and IFNγ-activated cells using a new ex vivo model of AMs from mice, fetal liver-derived alveolar-like macrophages (FLAMs), and immortalized bone marrow-derived macrophages (iBMDMs). Our findings reveal that IFNγ robustly activates both macrophage types; however, the profile of activated IFNγ-stimulated genes varies greatly between these cell types. Notably, FLAMs show limited expression of costimulatory markers essential for T cell activation upon stimulation with only IFNγ. To understand cell type-specific differences, we examined how the inhibition of the regulatory kinases GSK3α/β alters the IFNγ response. GSK3α/β controlled distinct IFNγ responses, and in AM-like cells, we found GSK3α/β restrained the induction of type I IFN and TNF, thus preventing the robust expression of costimulatory molecules and limiting CD4 + T cell activation. Together, these data suggest that the capacity of AMs to respond to IFNγ is restricted in a GSK3α/β-dependent manner and that IFNγ responses differ across distinct macrophage populations. These findings lay the groundwork to identify new therapeutic targets that activate protective pulmonary responses without driving deleterious inflammation." @default.
• W4385972018 created "2023-08-19" @default.
• W4385972018 creator A5010270095 @default.
• W4385972018 creator A5025928093 @default.
• W4385972018 creator A5067271594 @default.
• W4385972018 creator A5083026962 @default.
• W4385972018 creator A5092659956 @default.
• W4385972018 date "2023-08-18" @default.
• W4385972018 modified "2023-10-06" @default.
• W4385972018 title "GSK3α/β restrains IFNγ-inducible costimulatory molecule expression in alveolar macrophages, limiting CD4⁺T cell activation" @default.
• W4385972018 cites W1516618581 @default.
• W4385972018 cites W1573179618 @default.
• W4385972018 cites W1967578253 @default.
• W4385972018 cites W1970707135 @default.
• W4385972018 cites W1975705605 @default.
• W4385972018 cites W2006562909 @default.
• W4385972018 cites W2029971722 @default.
• W4385972018 cites W2052847440 @default.
• W4385972018 cites W2055348159 @default.
• W4385972018 cites W2070953990 @default.
• W4385972018 cites W2079297432 @default.
• W4385972018 cites W2085099489 @default.
• W4385972018 cites W2099443109 @default.
• W4385972018 cites W2100646399 @default.
• W4385972018 cites W2100872199 @default.
• W4385972018 cites W2109479865 @default.
• W4385972018 cites W2111740348 @default.
• W4385972018 cites W2130410032 @default.
• W4385972018 cites W2130473166 @default.
• W4385972018 cites W2131908212 @default.
• W4385972018 cites W2133402546 @default.
• W4385972018 cites W2136188258 @default.
• W4385972018 cites W2138207763 @default.
• W4385972018 cites W2143488564 @default.
• W4385972018 cites W2146245930 @default.
• W4385972018 cites W2150037895 @default.
• W4385972018 cites W2163759464 @default.
• W4385972018 cites W2167017590 @default.
• W4385972018 cites W2170551349 @default.
• W4385972018 cites W2179438025 @default.
• W4385972018 cites W2191790139 @default.
• W4385972018 cites W2346942712 @default.
• W4385972018 cites W2478985445 @default.
• W4385972018 cites W2803989981 @default.
• W4385972018 cites W2806558827 @default.
• W4385972018 cites W2883018577 @default.
• W4385972018 cites W2888406753 @default.
• W4385972018 cites W2911555743 @default.
• W4385972018 cites W2931943710 @default.
• W4385972018 cites W2963522010 @default.
• W4385972018 cites W2996420143 @default.
• W4385972018 cites W3012709102 @default.
• W4385972018 cites W3045180352 @default.
• W4385972018 cites W3087497174 @default.
• W4385972018 cites W3126306489 @default.
• W4385972018 cites W3154642949 @default.
• W4385972018 cites W3160163842 @default.
• W4385972018 cites W3168050509 @default.
• W4385972018 cites W3203559074 @default.
• W4385972018 cites W37815363 @default.
• W4385972018 cites W4205659783 @default.
• W4385972018 cites W4213112177 @default.
• W4385972018 cites W4213453160 @default.
• W4385972018 cites W4226051695 @default.
• W4385972018 cites W4226258683 @default.
• W4385972018 cites W4226361155 @default.
• W4385972018 cites W4317802100 @default.
• W4385972018 doi "https://doi.org/10.1101/2023.08.16.553574" @default.
• W4385972018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37645748" @default.
• W4385972018 hasPublicationYear "2023" @default.
• W4385972018 type Work @default.
• W4385972018 citedByCount "0" @default.
• W4385972018 crossrefType "posted-content" @default.
• W4385972018 hasAuthorship W4385972018A5010270095 @default.
• W4385972018 hasAuthorship W4385972018A5025928093 @default.
• W4385972018 hasAuthorship W4385972018A5067271594 @default.
• W4385972018 hasAuthorship W4385972018A5083026962 @default.
• W4385972018 hasAuthorship W4385972018A5092659956 @default.
• W4385972018 hasBestOaLocation W43859720181 @default.
• W4385972018 hasConcept C1491633281 @default.
• W4385972018 hasConcept C202751555 @default.
• W4385972018 hasConcept C203014093 @default.
• W4385972018 hasConcept C2776090121 @default.
• W4385972018 hasConcept C2776914184 @default.
• W4385972018 hasConcept C2778012055 @default.
• W4385972018 hasConcept C2778690821 @default.
• W4385972018 hasConcept C2779244956 @default.
• W4385972018 hasConcept C54355233 @default.
• W4385972018 hasConcept C55493867 @default.
• W4385972018 hasConcept C86803240 @default.
• W4385972018 hasConcept C8891405 @default.
• W4385972018 hasConcept C95444343 @default.
• W4385972018 hasConceptScore W4385972018C1491633281 @default.
• W4385972018 hasConceptScore W4385972018C202751555 @default.
• W4385972018 hasConceptScore W4385972018C203014093 @default.
• W4385972018 hasConceptScore W4385972018C2776090121 @default.
• W4385972018 hasConceptScore W4385972018C2776914184 @default.
• W4385972018 hasConceptScore W4385972018C2778012055 @default.
• W4385972018 hasConceptScore W4385972018C2778690821 @default.
• W4385972018 hasConceptScore W4385972018C2779244956 @default.

• next