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- W4385973183 endingPage "e100013" @default.
- W4385973183 startingPage "e100013" @default.
- W4385973183 abstract "Excessive alcohol drinking can cause pathological changes including carcinogenesis in the digestive tract from mouth to large intestine, but the underlying mechanisms are not fully understood. In this review, we discuss the effects of alcohol on small and large intestinal functions, such as leaky gut, dysbiosis and alterations of intestinal epithelium and gut immune dysfunctions, commonly referred to as alcohol-associated bowel disease (ABD). To date, detailed mechanistic insights into ABD are lacking. Accumulating evidence suggests a pathogenic role of ethanol metabolism in dysfunctions of the intestinal tract. Ethanol metabolism generates acetaldehyde and acetate, which could potentially promote functional disruptions of microbial and host components of the intestinal barrier along the gastrointestinal tract. The potential involvement of acetaldehyde and acetate in the pathogenesis of the underlying ABD, including cancer, is discussed. We also highlight some gaps in knowledge existing in the field of ABD. Finally, we discuss future directions in exploring the role of acetaldehyde and acetate generated during chronic alcohol intake in various pathologies affecting different sites of the intestinal tract." @default.
- W4385973183 created "2023-08-19" @default.
- W4385973183 creator A5012576740 @default.
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- W4385973183 creator A5077287945 @default.
- W4385973183 date "2023-08-01" @default.
- W4385973183 modified "2023-10-14" @default.
- W4385973183 title "Alcohol-associated bowel disease: new insights into pathogenesis" @default.
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