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- W4385973276 abstract "IntroductionHigh convection volumes in haemodiafiltration (HDF) result in improved survival, however, it remains unclear whether it is achievable in all patients.MethodsCONVINCE, a randomised controlled trial, randomised patients with end-stage kidney disease 1:1 to high-dose HDF versus high-flux haemodialysis continuation. We evaluated the proportion of patients achieving high-dose HDF target: convection volume per visit of ≥23 L (range ±1 L), at baseline, month 3, and month 6. We compared baseline characteristics in two ways: 1) patients on target for all three visits versus patients who missed target on ≥1 visits; and 2) patients on target for all three visits or missing it once versus patients who missed target on ≥2 visits.Results653 patients were randomised to HDF. Their mean age was 62.2 (SD 13.5) years, 36% were female, 81% had fistula vascular access, and 33% were diabetic. Across three visits, 75 patients (11%), 27 patients (4%), and 11 patients (2%) missed the convection volume target once, twice, and three times, respectively. Apart from diabetes, there were no apparent differences in patient characteristics between patients who always achieved the high-dose target (83%) and those who missed the target either once or more (17%), or twice or more (6%).ConclusionAchieving high-dose HDF is feasible for nearly all patients in CONVINCE and could be maintained during the 6-month follow-up period. Apart from diabetes there were no other indications for confounding by indication on multivariable analyses that may explain the potential survival advantage for patients receiving high-dose HDF." @default.
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- W4385973276 date "2023-08-01" @default.
- W4385973276 modified "2023-10-14" @default.
- W4385973276 title "High-Target Hemodiafiltration Convective Dose Achieved in Most Patients in a 6-Month Intermediary Analysis of the CONVINCE Randomized Controlled Trial" @default.
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- W4385973276 doi "https://doi.org/10.1016/j.ekir.2023.08.004" @default.
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