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- W4385977892 endingPage "4171" @default.
- W4385977892 startingPage "4171" @default.
- W4385977892 abstract "Acute Myeloid Leukemia (AML) is the second most common type of leukemia in children. Recent advances in high-resolution genomic profiling techniques have uncovered the mutational landscape of pediatric AML as distinct from adult AML. Overall survival rates of children with AML have dramatically improved in the past 40 years, currently reaching 70% to 80% in developed countries. This was accomplished by the intensification of conventional chemotherapy, improvement in risk stratification using leukemia-specific cytogenetics/molecular genetics and measurable residual disease, appropriate use of allogeneic hematopoietic stem cell transplantation, and improvement in supportive care. However, the principle therapeutic approach for pediatric AML has not changed substantially for decades and improvement in event-free survival is rather modest. Further refinements in risk stratification and the introduction of emerging novel therapies to contemporary therapy, through international collaboration, would be key solutions for further improvements in outcomes." @default.
- W4385977892 created "2023-08-19" @default.
- W4385977892 creator A5054682762 @default.
- W4385977892 creator A5084361647 @default.
- W4385977892 date "2023-08-18" @default.
- W4385977892 modified "2023-09-25" @default.
- W4385977892 title "Risk-Stratified Therapy for Pediatric Acute Myeloid Leukemia" @default.
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