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- W4385980713 abstract "Phospholipases are the enzymes that cause hydrolysis of phospholipids. Different phospholipases act at different sites in the structure of phospholipids. Phospholipase A2 removes a fatty acid from the sn-2 position, commonly producing arachidonic acid. Arachidonic acid is the precursor of eicosanoids and leukotrienes and performs important functions in the body including a role in cancer. Phospholipase A2 is of different types that are grouped together as a superfamily. Out of different members, secretory, cytosolic, and calcium-independent phospholipases have been studied extensively and are found associated with cancer. Secretory PLA2 (particularly sPLA2-IIA) appears to exert conflicting action and can act either as anticarcinogenic or procarcinogenic depending on the type of cancer. On the other hand, cytosolic PLA2 (particularly cPLA2α) and calcium-independent PLA2 (particularly iPLA2β) behave as procarcinogenic in most tumors. Recently, one role of PLA2, particularly cytosolic PLA2, is emerging as a radiosensitizer agent. Some inhibitors of cytosolic PLA2 can increase the response of malignant tissue to radiation therapy improving the overall prognosis of the disease. This chapter is an attempt to highlight these important aspects of different types of phospholipase A2 in cancer." @default.
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- W4385980713 date "2023-01-01" @default.
- W4385980713 modified "2023-10-14" @default.
- W4385980713 title "Emerging role of phospholipase A2 superfamily in cancer and treatment using radiation" @default.
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- W4385980713 doi "https://doi.org/10.1016/b978-0-323-95697-0.00006-6" @default.
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