FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385983299> ?p ?o ?g. }

• W4385983299 endingPage "S21" @default.
• W4385983299 startingPage "S21" @default.
• W4385983299 abstract "One goal of regenerative medicine is to rejuvenate tissues and extend lifespan by restoring the function of endogenous aged stem cells. However, evidence that somatic stem cells can be targeted in vivo to extend lifespan is still lacking. Here, we demonstrate that after a short systemic treatment with a specific inhibitor of the small RhoGTPase Cdc42 (CASIN), transplanting aged hematopoietic stem cells (HSCs) from treated mice is sufficient to extend the healthspan and lifespan of aged immunocompromised mice without additional treatment. In detail, we show that systemic CASIN treatment improves strength and endurance of aged mice by increasing the myogenic regenerative potential of aged skeletal muscle stem cells. Further, we show that CASIN modifies niche localization and H4K16ac polarity of HSCs in vivo. Single cell profiling reveals changes in HSC transcriptome, which underlie enhanced lymphoid and regenerative capacity in serial transplantation assays. Overall, we provide proof-of-concept evidence that a short systemic treatment to decrease Cdc42 activity improves the regenerative capacity of different endogenous aged stem cells in vivo, and that rejuvenated HSCs exert a broad systemic effect sufficient to extend murine health- and lifespan. One goal of regenerative medicine is to rejuvenate tissues and extend lifespan by restoring the function of endogenous aged stem cells. However, evidence that somatic stem cells can be targeted in vivo to extend lifespan is still lacking. Here, we demonstrate that after a short systemic treatment with a specific inhibitor of the small RhoGTPase Cdc42 (CASIN), transplanting aged hematopoietic stem cells (HSCs) from treated mice is sufficient to extend the healthspan and lifespan of aged immunocompromised mice without additional treatment. In detail, we show that systemic CASIN treatment improves strength and endurance of aged mice by increasing the myogenic regenerative potential of aged skeletal muscle stem cells. Further, we show that CASIN modifies niche localization and H4K16ac polarity of HSCs in vivo. Single cell profiling reveals changes in HSC transcriptome, which underlie enhanced lymphoid and regenerative capacity in serial transplantation assays. Overall, we provide proof-of-concept evidence that a short systemic treatment to decrease Cdc42 activity improves the regenerative capacity of different endogenous aged stem cells in vivo, and that rejuvenated HSCs exert a broad systemic effect sufficient to extend murine health- and lifespan." @default.
• W4385983299 created "2023-08-19" @default.
• W4385983299 creator A5007290070 @default.
• W4385983299 creator A5009491648 @default.
• W4385983299 creator A5015419512 @default.
• W4385983299 creator A5017335591 @default.
• W4385983299 creator A5020584779 @default.
• W4385983299 creator A5034818741 @default.
• W4385983299 creator A5041015051 @default.
• W4385983299 creator A5061170036 @default.
• W4385983299 creator A5063055821 @default.
• W4385983299 creator A5064647701 @default.
• W4385983299 creator A5067463217 @default.
• W4385983299 creator A5069853882 @default.
• W4385983299 creator A5074528628 @default.
• W4385983299 creator A5082856541 @default.
• W4385983299 creator A5089963770 @default.
• W4385983299 date "2023-01-01" @default.
• W4385983299 modified "2023-10-14" @default.
• W4385983299 title "1003 – TRANSPLANTING REJUVENATED BLOOD STEM CELLS EXTENDS LIFESPAN OF AGED MICE" @default.
• W4385983299 doi "https://doi.org/10.1016/j.exphem.2023.06.009" @default.
• W4385983299 hasPublicationYear "2023" @default.
• W4385983299 type Work @default.
• W4385983299 citedByCount "0" @default.
• W4385983299 crossrefType "journal-article" @default.
• W4385983299 hasAuthorship W4385983299A5007290070 @default.
• W4385983299 hasAuthorship W4385983299A5009491648 @default.
• W4385983299 hasAuthorship W4385983299A5015419512 @default.
• W4385983299 hasAuthorship W4385983299A5017335591 @default.
• W4385983299 hasAuthorship W4385983299A5020584779 @default.
• W4385983299 hasAuthorship W4385983299A5034818741 @default.
• W4385983299 hasAuthorship W4385983299A5041015051 @default.
• W4385983299 hasAuthorship W4385983299A5061170036 @default.
• W4385983299 hasAuthorship W4385983299A5063055821 @default.
• W4385983299 hasAuthorship W4385983299A5064647701 @default.
• W4385983299 hasAuthorship W4385983299A5067463217 @default.
• W4385983299 hasAuthorship W4385983299A5069853882 @default.
• W4385983299 hasAuthorship W4385983299A5074528628 @default.
• W4385983299 hasAuthorship W4385983299A5082856541 @default.
• W4385983299 hasAuthorship W4385983299A5089963770 @default.
• W4385983299 hasConcept C104317684 @default.
• W4385983299 hasConcept C10854531 @default.
• W4385983299 hasConcept C109159458 @default.
• W4385983299 hasConcept C123012128 @default.
• W4385983299 hasConcept C126322002 @default.
• W4385983299 hasConcept C134018914 @default.
• W4385983299 hasConcept C134305767 @default.
• W4385983299 hasConcept C16613235 @default.
• W4385983299 hasConcept C202751555 @default.
• W4385983299 hasConcept C203014093 @default.
• W4385983299 hasConcept C20875687 @default.
• W4385983299 hasConcept C28328180 @default.
• W4385983299 hasConcept C2911091166 @default.
• W4385983299 hasConcept C502942594 @default.
• W4385983299 hasConcept C54355233 @default.
• W4385983299 hasConcept C71924100 @default.
• W4385983299 hasConcept C86803240 @default.
• W4385983299 hasConcept C95444343 @default.
• W4385983299 hasConceptScore W4385983299C104317684 @default.
• W4385983299 hasConceptScore W4385983299C10854531 @default.
• W4385983299 hasConceptScore W4385983299C109159458 @default.
• W4385983299 hasConceptScore W4385983299C123012128 @default.
• W4385983299 hasConceptScore W4385983299C126322002 @default.
• W4385983299 hasConceptScore W4385983299C134018914 @default.
• W4385983299 hasConceptScore W4385983299C134305767 @default.
• W4385983299 hasConceptScore W4385983299C16613235 @default.
• W4385983299 hasConceptScore W4385983299C202751555 @default.
• W4385983299 hasConceptScore W4385983299C203014093 @default.
• W4385983299 hasConceptScore W4385983299C20875687 @default.
• W4385983299 hasConceptScore W4385983299C28328180 @default.
• W4385983299 hasConceptScore W4385983299C2911091166 @default.
• W4385983299 hasConceptScore W4385983299C502942594 @default.
• W4385983299 hasConceptScore W4385983299C54355233 @default.
• W4385983299 hasConceptScore W4385983299C71924100 @default.
• W4385983299 hasConceptScore W4385983299C86803240 @default.
• W4385983299 hasConceptScore W4385983299C95444343 @default.
• W4385983299 hasLocation W43859832991 @default.
• W4385983299 hasOpenAccess W4385983299 @default.
• W4385983299 hasPrimaryLocation W43859832991 @default.
• W4385983299 hasRelatedWork W1992103432 @default.
• W4385983299 hasRelatedWork W2014336765 @default.
• W4385983299 hasRelatedWork W2060908277 @default.
• W4385983299 hasRelatedWork W2079838338 @default.
• W4385983299 hasRelatedWork W2386459873 @default.
• W4385983299 hasRelatedWork W2416632361 @default.
• W4385983299 hasRelatedWork W2438531772 @default.
• W4385983299 hasRelatedWork W2588082616 @default.
• W4385983299 hasRelatedWork W3186344585 @default.
• W4385983299 hasRelatedWork W4378085261 @default.
• W4385983299 hasVolume "124" @default.
• W4385983299 isParatext "false" @default.
• W4385983299 isRetracted "false" @default.
• W4385983299 workType "article" @default.