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• W4385984199 abstract "<sec> <title>BACKGROUND</title> Vaccines have facilitated the substantial reduction and containment of COVID-19 transmission in many countries by early 2023. However, the long-term interconnection between vaccines, traits of the pathogen, vaccination strategies, and cases averted/trade-offs of health outcomes is not well understood. </sec> <sec> <title>OBJECTIVE</title> Estimate the long-term aversion effects and trade-offs of major health outcomes for the COVID-19 pandemic. </sec> <sec> <title>METHODS</title> Utilizing a compartment-calibrated model, I estimated the aversion/trade-offs effect on six major disease burdens (i.e., total/symptomatic/asymptomatic/hospitalized/ICU/death cases averted) over time conditional on a variety level of scenarios. </sec> <sec> <title>RESULTS</title> The findings implied that low-risk immunity profiles of booster doses increased the peak cases averted versus medium- and high-risk counterparts. The effect was most salient for the former paired with enhancing the rollout rate of doses, followed by the medium- and then high-risk scenarios. Positive and chronically durable aversion effects for the low-risk, in contrast, negative trade-offs and decreasing aversion effects for the suboptimal scenarios were observed. </sec> <sec> <title>CONCLUSIONS</title> Vaccination strategies, traits of pathogens, and traits of vaccines exert important roles in controlling the transmission of infectious diseases. While there are heterogeneities in vaccines, public strategies, social efforts, and other considerations, this work can provide an evidence-based rationale for the long-term trade-off analysis of vaccination and contribute to the sustainable containment of infectious diseases. </sec>" @default.
• W4385984199 created "2023-08-19" @default.
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• W4385984199 date "2023-08-17" @default.
• W4385984199 modified "2023-10-06" @default.
• W4385984199 title "Estimate the long-term aversion effects and trade-offs of major health outcomes for the COVID-19 pandemic (Preprint)" @default.
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• W4385984199 doi "https://doi.org/10.2196/preprints.51942" @default.
• W4385984199 hasPublicationYear "2023" @default.
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