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• W4385984472 abstract "Cellular senescence, a cell state characterized by growth arrest and insensitivity to growth stimulatory hormones, is accompanied by a massive change in chromatin organization. Senescence can be induced by a range of physiological signals and pathological stresses and was originally thought to be an irreversible state, implicated in normal development, wound healing, tumor suppression and aging. Recently cellular senescence was shown to be reversible in some cases, with exit being triggered by the modulation of the cell's transcriptional program by the four Yamanaka factors, the suppression of p53 or H3K9me3, PDK1, and/or depletion of AP-1. Coincident with senescence reversal are changes in chromatin organization, most notably the loss of senescence-associated heterochromatin foci (SAHF) found in oncogene-induced senescence. In addition to fixed-cell imaging, chromatin conformation capture and multi-omics have been used to examine chromatin reorganization at different spatial resolutions during senescence. They identify determinants of SAHF formation and other key features that differentiate distinct types of senescence. Not surprisingly, multiple factors, including the time of induction, the type of stress experienced, and the type of cell involved, influence the global reorganization of chromatin in senescence. Here we discuss how changes in the three-dimensional organization of the genome contribute to the regulation of transcription at different stages of senescence. In particular, the distinct contributions of heterochromatin- and lamina-mediated interactions, changes in gene expression, and other cellular control mechanisms are discussed. We propose that high-resolution temporal and spatial analyses of the chromatin landscape during senescence will identify early markers of the different senescence states to help guide clinical diagnosis." @default.
• W4385984472 created "2023-08-19" @default.
• W4385984472 creator A5038281692 @default.
• W4385984472 creator A5082924650 @default.
• W4385984472 date "2023-08-18" @default.
• W4385984472 modified "2023-10-14" @default.
• W4385984472 title "Dynamic 3D genome reorganization during senescence: defining cell states through chromatin" @default.
• W4385984472 cites W1862799510 @default.
• W4385984472 cites W1896708637 @default.
• W4385984472 cites W1965124005 @default.
• W4385984472 cites W1967365486 @default.
• W4385984472 cites W1970924670 @default.
• W4385984472 cites W1971451591 @default.
• W4385984472 cites W2004314923 @default.
• W4385984472 cites W2010417927 @default.
• W4385984472 cites W2031866174 @default.
• W4385984472 cites W2042471279 @default.
• W4385984472 cites W2042789810 @default.
• W4385984472 cites W2047330128 @default.
• W4385984472 cites W2061619522 @default.
• W4385984472 cites W2073026107 @default.
• W4385984472 cites W2074350232 @default.
• W4385984472 cites W2084308291 @default.
• W4385984472 cites W2085444106 @default.
• W4385984472 cites W2087404852 @default.
• W4385984472 cites W2097265055 @default.
• W4385984472 cites W2098995242 @default.
• W4385984472 cites W2115852450 @default.
• W4385984472 cites W2116054786 @default.
• W4385984472 cites W2122097157 @default.
• W4385984472 cites W2124614845 @default.
• W4385984472 cites W2130458932 @default.
• W4385984472 cites W2140930678 @default.
• W4385984472 cites W2145578278 @default.
• W4385984472 cites W2152602162 @default.
• W4385984472 cites W2153643905 @default.
• W4385984472 cites W2155846733 @default.
• W4385984472 cites W2262370504 @default.
• W4385984472 cites W2340948097 @default.
• W4385984472 cites W2418343927 @default.
• W4385984472 cites W2526226937 @default.
• W4385984472 cites W2535123950 @default.
• W4385984472 cites W2565424224 @default.
• W4385984472 cites W2607008467 @default.
• W4385984472 cites W2734636788 @default.
• W4385984472 cites W2742007963 @default.
• W4385984472 cites W2749511637 @default.
• W4385984472 cites W2754653878 @default.
• W4385984472 cites W2762611634 @default.
• W4385984472 cites W2765547660 @default.
• W4385984472 cites W2777786283 @default.
• W4385984472 cites W2780826946 @default.
• W4385984472 cites W2783734371 @default.
• W4385984472 cites W2788548733 @default.
• W4385984472 cites W2795649462 @default.
• W4385984472 cites W2799540870 @default.
• W4385984472 cites W2884053119 @default.
• W4385984472 cites W2884160797 @default.
• W4385984472 cites W2894289085 @default.
• W4385984472 cites W2901540370 @default.
• W4385984472 cites W2917634600 @default.
• W4385984472 cites W2921773684 @default.
• W4385984472 cites W2945510241 @default.
• W4385984472 cites W2949421968 @default.
• W4385984472 cites W2952203741 @default.
• W4385984472 cites W2954376097 @default.
• W4385984472 cites W2972445800 @default.
• W4385984472 cites W2972909971 @default.
• W4385984472 cites W2974792094 @default.
• W4385984472 cites W2995325699 @default.
• W4385984472 cites W3007727593 @default.
• W4385984472 cites W3009321072 @default.
• W4385984472 cites W3013167866 @default.
• W4385984472 cites W3013543222 @default.
• W4385984472 cites W3015167195 @default.
• W4385984472 cites W3016447954 @default.
• W4385984472 cites W3025824156 @default.
• W4385984472 cites W3027739401 @default.
• W4385984472 cites W3033840227 @default.
• W4385984472 cites W3039246220 @default.
• W4385984472 cites W3047671778 @default.
• W4385984472 cites W3087868350 @default.
• W4385984472 cites W3108031567 @default.
• W4385984472 cites W3108996799 @default.
• W4385984472 cites W3137176315 @default.
• W4385984472 cites W3173458376 @default.
• W4385984472 cites W3211983635 @default.
• W4385984472 cites W4205519160 @default.
• W4385984472 cites W4207041710 @default.
• W4385984472 cites W4224096428 @default.
• W4385984472 cites W4226211557 @default.
• W4385984472 cites W4282584831 @default.
• W4385984472 cites W4291793058 @default.
• W4385984472 cites W4292004337 @default.
• W4385984472 cites W4318027593 @default.
• W4385984472 cites W4362530462 @default.
• W4385984472 doi "https://doi.org/10.1038/s41418-023-01197-y" @default.
• W4385984472 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37596440" @default.
• W4385984472 hasPublicationYear "2023" @default.
• W4385984472 type Work @default.

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