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Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385988227> ?p ?o ?g. }

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• W4385988227 startingPage "115614" @default.
• W4385988227 abstract "The emergence of the graphene-based hybrid electrical-electrochemical vertical device (EEVD) has introduced a promising nanostructured biosensor tailored for point-of-care applications. In this study, we present an innovative EEVD capable of simultaneously detecting the receptor binding domain (RBD) of the SARS-CoV-2 spike protein in both serum and saliva. The foundation of the EEVD lies in a poly-neutral red-graphene heterojunction, which has been enhanced with a bioconjugate of gold nanoparticles and antibodies. The biodevice demonstrates a remarkable limit of detection, registering at the femtomolar scale (2.86 fmol L-1 or 0.1 pg mL-1). Its sensitivity is characterized by a 6.1 mV/decade response, and its operational range spans 10-12 to 10-7 g mL-1 in both serum and saliva samples. With a 20.0 μL of biological samples and a rapid processing time of under 10 min, the EEVD achieves the feat of dual antigen detection. The tests achieved 100.0% specificity, accuracy, and sensitivity in saliva, and 100.0% specificity, 88.9% accuracy, and 80.0% sensitivity in serum. This study highlights the EEVD as a low-cost solution of rapid viral detection during the crucial initial phases of COVID-19 infections." @default.
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• W4385988227 date "2023-11-01" @default.
• W4385988227 modified "2023-10-14" @default.
• W4385988227 title "Expanding the application of graphene vertical devices to dual femtomolar detection of SARS-CoV-2 receptor binding domain in serum and saliva" @default.
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• W4385988227 doi "https://doi.org/10.1016/j.bios.2023.115614" @default.
• W4385988227 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37607446" @default.
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