FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385988746> ?p ?o ?g. }

• W4385988746 endingPage "175996" @default.
• W4385988746 startingPage "175996" @default.
• W4385988746 abstract "Frizzled 6 (Fzd6) is involved in the development of various disorders; however, its role in the etiology of depression remains unclear. We aimed to determine the potential regulatory mechanisms of Fzd6 as a Wnt receptor in depression.Mice were divided into four groups: wild-type control (Fzd6WT-control), Fzd6 mutant control (Fzd6Q152E-control), wild-type reserpine (Fzd6WT-reserpine), and Fzd6 mutant reserpine (Fzd6Q152E-reserpine). Reserpine (0.5 mg/kg) was injected intraperitoneally for 10 days. Four behavioral experiments were performed to assess the effects of Fzd6Q152E on depression-like behaviors in the reserpine-treated mice. Blood samples were collected for an enzyme-linked immunosorbent assay (ELISA). Gene expression in the hippocampus was quantified using quantitative real-time polymerase chain reaction (qRT-PCR), and protein expression levels in the hippocampus were identified using western blotting.The Fzd6 mutation affected reserpine-induced depression-like behavioral changes in mice. ELISA revealed significantly reduced serum levels of 5-hydroxytryptamine (5-HT), brain-derived neurotrophic factor (BDNF), and norepinephrine in both Fzd6Q152E-reserpine and Fzd6WT-reserpine mice, with a more pronounced decrease in Fzd6Q152E-reserpine mice, especially in norepinephrine expression. The qRT-PCR results showed significantly decreased Fzd6 expression in Fzd6Q152E-reserpine mice and altered expression of Dkk2, Gsk-3β, Lrp6, Wnt2, Wnt3, and Wnt3a in the Wnt pathway. Western blotting revealed decreased Fzd6 protein expression in Fzd6Q152E-control mice compared to Fzd6WT-control mice, whereas Fzd6 protein expression was restored in Fzd6Q152E-reserpine mice, and Gsk-3β expression was significantly changed.Fzd6 potentially influences reserpine-induced depressive behavioral changes and serum depressive factor alterations and modulates the expression of the Wnt signaling pathway in the hippocampus of depressed mice." @default.
• W4385988746 created "2023-08-19" @default.
• W4385988746 creator A5001003276 @default.
• W4385988746 creator A5012988822 @default.
• W4385988746 creator A5014540994 @default.
• W4385988746 creator A5022995047 @default.
• W4385988746 creator A5051533408 @default.
• W4385988746 creator A5057279000 @default.
• W4385988746 creator A5070111067 @default.
• W4385988746 creator A5082061805 @default.
• W4385988746 creator A5084661620 @default.
• W4385988746 date "2023-10-01" @default.
• W4385988746 modified "2023-10-14" @default.
• W4385988746 title "Frizzled 6 mutation regulates reserpine-induced depression-like behavior and Wnt signaling pathway in mice" @default.
• W4385988746 cites W1756201586 @default.
• W4385988746 cites W1905851592 @default.
• W4385988746 cites W1968900418 @default.
• W4385988746 cites W1977395368 @default.
• W4385988746 cites W1999385317 @default.
• W4385988746 cites W2025500109 @default.
• W4385988746 cites W2067535960 @default.
• W4385988746 cites W2106134852 @default.
• W4385988746 cites W2109281837 @default.
• W4385988746 cites W2111083789 @default.
• W4385988746 cites W2111113377 @default.
• W4385988746 cites W2129879090 @default.
• W4385988746 cites W2164012002 @default.
• W4385988746 cites W2301512483 @default.
• W4385988746 cites W2467328988 @default.
• W4385988746 cites W2519325934 @default.
• W4385988746 cites W2583083439 @default.
• W4385988746 cites W2608855643 @default.
• W4385988746 cites W2776975812 @default.
• W4385988746 cites W2809733576 @default.
• W4385988746 cites W2883646061 @default.
• W4385988746 cites W2890815771 @default.
• W4385988746 cites W2892030795 @default.
• W4385988746 cites W2898150668 @default.
• W4385988746 cites W2903093081 @default.
• W4385988746 cites W2946965809 @default.
• W4385988746 cites W2953336279 @default.
• W4385988746 cites W3007771094 @default.
• W4385988746 cites W3011659826 @default.
• W4385988746 cites W3012493302 @default.
• W4385988746 cites W3021678070 @default.
• W4385988746 cites W3024517292 @default.
• W4385988746 cites W3109478496 @default.
• W4385988746 cites W3133539690 @default.
• W4385988746 cites W3164598487 @default.
• W4385988746 cites W3197768292 @default.
• W4385988746 cites W3209464262 @default.
• W4385988746 cites W4205306816 @default.
• W4385988746 cites W4211263234 @default.
• W4385988746 cites W4223437611 @default.
• W4385988746 cites W4224862907 @default.
• W4385988746 cites W4231054479 @default.
• W4385988746 cites W4292405811 @default.
• W4385988746 cites W4307703022 @default.
• W4385988746 doi "https://doi.org/10.1016/j.ejphar.2023.175996" @default.
• W4385988746 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37597646" @default.
• W4385988746 hasPublicationYear "2023" @default.
• W4385988746 type Work @default.
• W4385988746 citedByCount "0" @default.
• W4385988746 crossrefType "journal-article" @default.
• W4385988746 hasAuthorship W4385988746A5001003276 @default.
• W4385988746 hasAuthorship W4385988746A5012988822 @default.
• W4385988746 hasAuthorship W4385988746A5014540994 @default.
• W4385988746 hasAuthorship W4385988746A5022995047 @default.
• W4385988746 hasAuthorship W4385988746A5051533408 @default.
• W4385988746 hasAuthorship W4385988746A5057279000 @default.
• W4385988746 hasAuthorship W4385988746A5070111067 @default.
• W4385988746 hasAuthorship W4385988746A5082061805 @default.
• W4385988746 hasAuthorship W4385988746A5084661620 @default.
• W4385988746 hasConcept C104317684 @default.
• W4385988746 hasConcept C126322002 @default.
• W4385988746 hasConcept C134018914 @default.
• W4385988746 hasConcept C137620995 @default.
• W4385988746 hasConcept C2776415932 @default.
• W4385988746 hasConcept C2777842393 @default.
• W4385988746 hasConcept C55493867 @default.
• W4385988746 hasConcept C62478195 @default.
• W4385988746 hasConcept C71924100 @default.
• W4385988746 hasConcept C85265743 @default.
• W4385988746 hasConcept C86803240 @default.
• W4385988746 hasConcept C98274493 @default.
• W4385988746 hasConceptScore W4385988746C104317684 @default.
• W4385988746 hasConceptScore W4385988746C126322002 @default.
• W4385988746 hasConceptScore W4385988746C134018914 @default.
• W4385988746 hasConceptScore W4385988746C137620995 @default.
• W4385988746 hasConceptScore W4385988746C2776415932 @default.
• W4385988746 hasConceptScore W4385988746C2777842393 @default.
• W4385988746 hasConceptScore W4385988746C55493867 @default.
• W4385988746 hasConceptScore W4385988746C62478195 @default.
• W4385988746 hasConceptScore W4385988746C71924100 @default.
• W4385988746 hasConceptScore W4385988746C85265743 @default.
• W4385988746 hasConceptScore W4385988746C86803240 @default.
• W4385988746 hasConceptScore W4385988746C98274493 @default.
• W4385988746 hasLocation W43859887461 @default.

• next