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- W4385989467 abstract "The intestinal epithelium has high intrinsic turnover rate, and the precise renewal of the epithelium is dependent on the microenvironment. The intestine is innervated by a dense network of peripheral nerves that controls various aspects of intestinal physiology. However, the role of neurons in regulating epithelial cell regeneration remains largely unknown. Here, we investigated the effects of gut-innervating adrenergic nerves on epithelial cell repair following irradiation (IR)-induced injury. We observed that adrenergic nerve density in the small intestine increased post IR, while chemical adrenergic denervation impaired epithelial regeneration. Single-cell RNA sequencing experiments revealed a decrease in IL-22 signaling post IR in denervated animals. Combining pharmacologic and genetic tools, we demonstrate that β-adrenergic receptor signaling drives IL-22 production from type 3 innate lymphoid cells (ILC3s) post IR, which in turn promotes epithelial regeneration. These results define an adrenergic-ILC3 axis important for intestinal regeneration." @default.
- W4385989467 created "2023-08-19" @default.
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- W4385989467 date "2023-09-01" @default.
- W4385989467 modified "2023-10-06" @default.
- W4385989467 title "Adrenergic nerves regulate intestinal regeneration through IL-22 signaling from type 3 innate lymphoid cells" @default.
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- W4385989467 doi "https://doi.org/10.1016/j.stem.2023.07.013" @default.
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