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- W4385991333 abstract "Binding of specific receptors on the cell membrane activates specific phospholipases. Based on the site of action of cleavage at phospholipid positions, phospholipase are classified into four different types of phospholipases, namely PLA, PLB, PLC, and PLD. Phospholipids have a phosphate group, two alcohols, and one or two fatty acids as part of their general structure. Atrial cardiomyocytes, ventricular cardiomyocytes, endothelial cells (ECs), fibroblasts (FBs), pericytes, smooth muscle cells (SMCs), immune cells (myeloid and lymphoid), adipocytes, mesothelium cells, and neuronal cells are among several cell types found in cardiac tissue. The majority of the cells that reside in heart tissues are cardiomyocytes. The lipid mediators prostaglandin and leukotriene, which are eicosanoid derivatives of arachidonic acid (AA), play key roles in inflammation. The cytosolic Ca2+ concentration is regulated by the intracellular storage sarcoplasmic reticulum, which controls Ca2+ release. Eicosanoids that are produced from AA by the enzyme PLA2 trigger the release of prostaglandins and leukotrienes. In the canine heart (sarcolemma fraction), it was found that 21% of AA and 75% of plasmenyl choline and plasmenyl ethanolamine PLC regulates the cytosolic release of Ca2+ ions from Ca2+ ions channels present in the intercellular sarcoplasmic reticulum. Each individual compound obtained during phospholipase activity plays a different biological role. A percentage of plasmalogens are tissue-specific and differ among various animal species. This chapter is an attempt to outline the role of phospholipase in cardiovascular diseases (CVDs) and their endocrine regulatory mechanism, along with the discovery of phospholipase-based drugs and mechanism of action in CVDs." @default.
- W4385991333 created "2023-08-19" @default.
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- W4385991333 date "2023-01-01" @default.
- W4385991333 modified "2023-10-14" @default.
- W4385991333 title "Endocrine regulation of phospholipase as a therapeutic target for cardiovascular diseases" @default.
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- W4385991333 doi "https://doi.org/10.1016/b978-0-443-21800-2.00005-1" @default.
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