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- W4385993203 abstract "Three available methods used to determine heparin loading dose were studied to determine the most reliable method for reaching a target pre-bypass activated clotting time (ACT) of 510 seconds. One hundred and seven patients were randomly assigned to one of three treatment methods: A) 300 units/kg; B) Hemostasis Management System (HMS); C) RX/DX. Five different lots of heparin were assigned to Groups A and B, and Group C had one heparin lot. Different lots were used to account for possible variations in heparin activity. Post-skin incision ACTs, post-heparin pre-bypass ACTs, and heparin loading doses were compared. The mean and standard deviation of the post-heparin pre-bypass ACTs were used to determine which method was most reliable to obtain a desired ACT. There was no statistical difference between different heparin lots. There was no difference in the post-heparin ACTs for the three methods (A:487±135 vs. B:474±105 vs. C:474±111 sec). There was a statistically significant difference between the standard deviation for the HMS and 300 u/kg standard deviations (p<0.05). The HMS has the smallest deviation which makes it the most reliable predictor of heparin loading doses to reach a target ACT for cardiopulmonary bypass." @default.
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- W4385993203 date "1996-06-01" @default.
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- W4385993203 title "Comparison of Three Methods to Estimate Heparin Loading Dose for Cardiopulmonary Bypass" @default.
- W4385993203 doi "https://doi.org/10.1051/ject/199628267" @default.
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