FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385994557> ?p ?o ?g. }

• W4385994557 abstract "The left and right occipital arteries provide blood supply to afferent cell bodies in the ipsilateral nodose and petrosal ganglia. This supply is free of an effective blood-ganglion barrier, so changes in occipital artery blood flow directly affect the access of circulating factors to the afferent cell bodies. The application of infrared (IR) light to modulate neural and other cell processes has yielded information about basic biological processes within tissues and is gaining traction as a potential therapy for a variety of disease processes. To address whether IR can directly modulate vascular function, we performed wire myography studies to determine the actions of IR on occipital arteries isolated from male Sprague-Dawley rats. Based on our previous research that functionally-important differences exist between occipital artery segments close to their origin at the external carotid artery (ECA) and those closer to the nodose ganglion, the occipital arteries were dissected into two segments, one closer to the ECA and the other closer to the nodose ganglion. Segments were constricted with 5-hydroxytryptamine to a level equal to 50% of the maximal response generated by the application of a high (80 mM) concentration of K+ ions. The direct application of pulsed IR (1,460 nm) for 5 s produced a rapid vasodilation in occipital arteries that was significantly more pronounced in segments closest to the ECA, although the ECA itself was minimally responsive. The vasodilation remained for a substantial time (at least 120 s) after cessation of IR application. The vasodilation during and following cessation of the IR application was markedly diminished in occipital arteries denuded of the endothelium. In addition, the vasodilation elicited by IR in endothelium-intact occipital arteries was substantially reduced in the presence of a selective inhibitor of the nitric oxide-sensitive guanylate cyclase, 1H-[1,2,4]oxadiazolo [4,3-a]quinoxalin-1-one (ODQ). It appears that IR causes endothelium-dependent, nitric-oxide-mediated vasodilation in the occipital arteries of the rat. The ability of IR to generate rapid and sustained vasodilation may provide new therapeutic approaches for restoring or improving blood flow to targeted tissues." @default.
• W4385994557 created "2023-08-19" @default.
• W4385994557 creator A5000929996 @default.
• W4385994557 creator A5009698775 @default.
• W4385994557 creator A5010311053 @default.
• W4385994557 creator A5030464289 @default.
• W4385994557 creator A5067336969 @default.
• W4385994557 creator A5086264408 @default.
• W4385994557 creator A5089958834 @default.
• W4385994557 date "2023-08-16" @default.
• W4385994557 modified "2023-10-17" @default.
• W4385994557 title "Infrared light elicits endothelium-dependent vasodilation in isolated occipital arteries of the rat via soluble guanylyl cyclase-dependent mechanisms" @default.
• W4385994557 cites W1565099286 @default.
• W4385994557 cites W1565165145 @default.
• W4385994557 cites W1912414577 @default.
• W4385994557 cites W1913428129 @default.
• W4385994557 cites W1938580125 @default.
• W4385994557 cites W1967609781 @default.
• W4385994557 cites W1970445852 @default.
• W4385994557 cites W1973526984 @default.
• W4385994557 cites W1979345515 @default.
• W4385994557 cites W1983140929 @default.
• W4385994557 cites W1986577456 @default.
• W4385994557 cites W1987022755 @default.
• W4385994557 cites W1991517583 @default.
• W4385994557 cites W1991902612 @default.
• W4385994557 cites W2013377994 @default.
• W4385994557 cites W2013806934 @default.
• W4385994557 cites W2014833533 @default.
• W4385994557 cites W2019148704 @default.
• W4385994557 cites W2021072126 @default.
• W4385994557 cites W2024918913 @default.
• W4385994557 cites W2030489390 @default.
• W4385994557 cites W2031968135 @default.
• W4385994557 cites W2035699598 @default.
• W4385994557 cites W2037597722 @default.
• W4385994557 cites W2040984310 @default.
• W4385994557 cites W2042315639 @default.
• W4385994557 cites W2049673744 @default.
• W4385994557 cites W2054758240 @default.
• W4385994557 cites W2054804294 @default.
• W4385994557 cites W2057772434 @default.
• W4385994557 cites W2060718012 @default.
• W4385994557 cites W2064391857 @default.
• W4385994557 cites W2068062923 @default.
• W4385994557 cites W2068108888 @default.
• W4385994557 cites W2069368135 @default.
• W4385994557 cites W2069421197 @default.
• W4385994557 cites W2073868089 @default.
• W4385994557 cites W2077688844 @default.
• W4385994557 cites W2081874031 @default.
• W4385994557 cites W2087323735 @default.
• W4385994557 cites W2087955550 @default.
• W4385994557 cites W2097273912 @default.
• W4385994557 cites W2099133178 @default.
• W4385994557 cites W2099863372 @default.
• W4385994557 cites W2113939126 @default.
• W4385994557 cites W2117597411 @default.
• W4385994557 cites W2122238986 @default.
• W4385994557 cites W2132486325 @default.
• W4385994557 cites W2134135049 @default.
• W4385994557 cites W2163721144 @default.
• W4385994557 cites W2170523337 @default.
• W4385994557 cites W2185263169 @default.
• W4385994557 cites W2199264035 @default.
• W4385994557 cites W2239875738 @default.
• W4385994557 cites W2310167664 @default.
• W4385994557 cites W2411573992 @default.
• W4385994557 cites W2417375737 @default.
• W4385994557 cites W2418402887 @default.
• W4385994557 cites W2588949028 @default.
• W4385994557 cites W2607303579 @default.
• W4385994557 cites W2622059239 @default.
• W4385994557 cites W2757610729 @default.
• W4385994557 cites W2801274718 @default.
• W4385994557 cites W2890630804 @default.
• W4385994557 cites W2980849965 @default.
• W4385994557 cites W3092346227 @default.
• W4385994557 cites W3097843595 @default.
• W4385994557 cites W3106836330 @default.
• W4385994557 cites W3109721048 @default.
• W4385994557 cites W3109888177 @default.
• W4385994557 cites W3132342399 @default.
• W4385994557 cites W3154849666 @default.
• W4385994557 cites W3162806326 @default.
• W4385994557 cites W3184028953 @default.
• W4385994557 cites W4206816234 @default.
• W4385994557 cites W4225283370 @default.
• W4385994557 cites W2018389428 @default.
• W4385994557 doi "https://doi.org/10.3389/fphys.2023.1219998" @default.
• W4385994557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37664436" @default.
• W4385994557 hasPublicationYear "2023" @default.
• W4385994557 type Work @default.
• W4385994557 citedByCount "0" @default.
• W4385994557 crossrefType "journal-article" @default.
• W4385994557 hasAuthorship W4385994557A5000929996 @default.
• W4385994557 hasAuthorship W4385994557A5009698775 @default.
• W4385994557 hasAuthorship W4385994557A5010311053 @default.
• W4385994557 hasAuthorship W4385994557A5030464289 @default.
• W4385994557 hasAuthorship W4385994557A5067336969 @default.

• next