Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385994610> ?p ?o ?g. }
- W4385994610 abstract "Diabetes mellitus (DM) is a chronic metabolic disorder. Hepatopathy is one of the serious effects of DM Melatonin (MT) is a potent endogenous antioxidant that can control insulin output. However, little information is available about the potential association between melatonin and hepatic alpha-fetoprotein expression in diabetes.This study was conducted to assess the influence of MT on diabetes-related hepatic injuries and to determine how β-cells of the pancreas in diabetic rats respond to MT administration.Forty rats were assigned to four groups at random (ten animals per group). Group I served as a normal control group. Group II was induced with DM, and a single dose of freshly prepared streptozotocin (45 mg/kg body weight) was intraperitoneally injected. In Group III, rats received 10 mg/kg/day of intraperitoneal melatonin (IP MT) intraperitoneally over a period of 4 weeks. In Group IV (DM + MT), following the induction of diabetes, rats received MT (the same as in Group III). Fasting blood sugar, glycosylated hemoglobin (HbA1c), and serum insulin levels were assessed at the end of the experimental period. Serum liver function tests were performed. The pancreas and liver were examined histopathologically and immunohistochemically for insulin and alpha-fetoprotein (AFP) antibodies, respectively.MT was found to significantly modulate the raised blood glucose, HbA1c, and insulin levels induced by diabetes, as well as the decreased alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Furthermore, MT attenuated diabetic degenerative changes in the pancreas and the hepatic histological structure, increased the β-cell percentage area, and decreased AFP expression in the liver tissue. It attenuated diabetes-induced hepatic injury by restoring pancreatic β-cells; its antioxidant effect also reduced hepatocyte injury.Collectively, the present study confirmed the potential benefits of MT in downregulating the increased hepatic alpha-fetoprotein expression and in restoring pancreatic β-cells in a streptozotocin-induced diabetic rat model, suggesting its promising role in the treatment of diabetes." @default.
- W4385994610 created "2023-08-19" @default.
- W4385994610 creator A5012303372 @default.
- W4385994610 creator A5018141895 @default.
- W4385994610 creator A5020041675 @default.
- W4385994610 creator A5023594833 @default.
- W4385994610 creator A5028584922 @default.
- W4385994610 creator A5029851400 @default.
- W4385994610 creator A5033806941 @default.
- W4385994610 creator A5036261422 @default.
- W4385994610 creator A5036955411 @default.
- W4385994610 creator A5052782016 @default.
- W4385994610 creator A5054370050 @default.
- W4385994610 creator A5069507975 @default.
- W4385994610 creator A5081906980 @default.
- W4385994610 creator A5082267754 @default.
- W4385994610 creator A5088125799 @default.
- W4385994610 creator A5092664473 @default.
- W4385994610 date "2023-08-16" @default.
- W4385994610 modified "2023-10-17" @default.
- W4385994610 title "Melatonin downregulates the increased hepatic alpha-fetoprotein expression and restores pancreatic beta cells in a streptozotocin-induced diabetic rat model: a clinical, biochemical, immunohistochemical, and descriptive histopathological study" @default.
- W4385994610 cites W1144846780 @default.
- W4385994610 cites W1525705765 @default.
- W4385994610 cites W1848910737 @default.
- W4385994610 cites W1877383087 @default.
- W4385994610 cites W1973595940 @default.
- W4385994610 cites W1976191764 @default.
- W4385994610 cites W1987125621 @default.
- W4385994610 cites W1989239469 @default.
- W4385994610 cites W2003450091 @default.
- W4385994610 cites W2014710963 @default.
- W4385994610 cites W2026293316 @default.
- W4385994610 cites W2042733656 @default.
- W4385994610 cites W2043134073 @default.
- W4385994610 cites W2046613083 @default.
- W4385994610 cites W2073598814 @default.
- W4385994610 cites W2074871320 @default.
- W4385994610 cites W2131444090 @default.
- W4385994610 cites W2153866915 @default.
- W4385994610 cites W2155259844 @default.
- W4385994610 cites W2163164020 @default.
- W4385994610 cites W2164373861 @default.
- W4385994610 cites W2344868259 @default.
- W4385994610 cites W2346004281 @default.
- W4385994610 cites W2360439189 @default.
- W4385994610 cites W2510991852 @default.
- W4385994610 cites W2621132667 @default.
- W4385994610 cites W2727381053 @default.
- W4385994610 cites W2778535823 @default.
- W4385994610 cites W2789765203 @default.
- W4385994610 cites W2793292533 @default.
- W4385994610 cites W2806297165 @default.
- W4385994610 cites W2808017755 @default.
- W4385994610 cites W2889773757 @default.
- W4385994610 cites W2903148550 @default.
- W4385994610 cites W2918136845 @default.
- W4385994610 cites W2944697388 @default.
- W4385994610 cites W2962762119 @default.
- W4385994610 cites W2964213864 @default.
- W4385994610 cites W2984872982 @default.
- W4385994610 cites W2995691142 @default.
- W4385994610 cites W2997888679 @default.
- W4385994610 cites W2998017327 @default.
- W4385994610 cites W3000706737 @default.
- W4385994610 cites W3004051276 @default.
- W4385994610 cites W3016262322 @default.
- W4385994610 cites W3019658318 @default.
- W4385994610 cites W3037966929 @default.
- W4385994610 cites W3081584251 @default.
- W4385994610 cites W3132130261 @default.
- W4385994610 cites W3137198223 @default.
- W4385994610 cites W3154076471 @default.
- W4385994610 cites W3159422802 @default.
- W4385994610 cites W3175062399 @default.
- W4385994610 cites W3199872630 @default.
- W4385994610 cites W3207043997 @default.
- W4385994610 cites W4200393838 @default.
- W4385994610 cites W4213376308 @default.
- W4385994610 cites W4221108647 @default.
- W4385994610 cites W4253079697 @default.
- W4385994610 cites W4292004267 @default.
- W4385994610 cites W4293106324 @default.
- W4385994610 cites W4294989754 @default.
- W4385994610 cites W4306969743 @default.
- W4385994610 cites W4362520023 @default.
- W4385994610 cites W4384695278 @default.
- W4385994610 doi "https://doi.org/10.3389/fvets.2023.1214533" @default.
- W4385994610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37655263" @default.
- W4385994610 hasPublicationYear "2023" @default.
- W4385994610 type Work @default.
- W4385994610 citedByCount "0" @default.
- W4385994610 crossrefType "journal-article" @default.
- W4385994610 hasAuthorship W4385994610A5012303372 @default.
- W4385994610 hasAuthorship W4385994610A5018141895 @default.
- W4385994610 hasAuthorship W4385994610A5020041675 @default.
- W4385994610 hasAuthorship W4385994610A5023594833 @default.
- W4385994610 hasAuthorship W4385994610A5028584922 @default.
- W4385994610 hasAuthorship W4385994610A5029851400 @default.
- W4385994610 hasAuthorship W4385994610A5033806941 @default.
- W4385994610 hasAuthorship W4385994610A5036261422 @default.