Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385995093> ?p ?o ?g. }
- W4385995093 endingPage "1632" @default.
- W4385995093 startingPage "1632" @default.
- W4385995093 abstract "A series of copper(II) complexes with the formula [Cu2+Hy(x)Car%] varying the molecular weight (MW) of Hyaluronic acid (Hy, x = 200 or 700 kDa) conjugated with carnosine (Car) present at different loading were synthesized and characterized via different spectroscopic techniques. The metal complexes behaved as Cu, Zn-superoxide dismutase (SOD1) mimics and showed some of the most efficient reaction rate values produced using a synthetic and water-soluble copper(II)-based SOD mimic reported to date. The increase in the percentage of Car moieties parallels the enhancement of the I50 value determined via the indirect method of Fridovich. The presence of the non-functionalized Hy OH groups favors the scavenger activity of the copper(II) complexes with HyCar, recalling similar behavior previously found for the copper(II) complexes with Car conjugated using β-cyclodextrin or trehalose. In keeping with the new abilities of SOD1 to activate protective agents against oxidative stress in rheumatoid arthritis and osteoarthritis diseases, Cu2+ interaction with HyCar promotes the nuclear translocation of erythroid 2-related factor that regulates the expressions of target genes, including Heme-Oxigenase-1, thus stimulating an antioxidant response in osteoblasts subjected to an inflammatory/oxidative insult." @default.
- W4385995093 created "2023-08-19" @default.
- W4385995093 creator A5000715277 @default.
- W4385995093 creator A5011438031 @default.
- W4385995093 creator A5016086274 @default.
- W4385995093 creator A5021934963 @default.
- W4385995093 creator A5050818579 @default.
- W4385995093 creator A5052915971 @default.
- W4385995093 creator A5061172141 @default.
- W4385995093 creator A5065473672 @default.
- W4385995093 creator A5066129241 @default.
- W4385995093 creator A5068408804 @default.
- W4385995093 creator A5074975954 @default.
- W4385995093 creator A5075841925 @default.
- W4385995093 creator A5082313839 @default.
- W4385995093 creator A5089029390 @default.
- W4385995093 date "2023-08-18" @default.
- W4385995093 modified "2023-10-06" @default.
- W4385995093 title "Copper(II) Complexes with Carnosine Conjugates of Hyaluronic Acids at Different Dipeptide Loading Percentages Behave as Multiple SOD Mimics and Stimulate Nrf2 Translocation and Antioxidant Response in In Vitro Inflammatory Model" @default.
- W4385995093 cites W1485220938 @default.
- W4385995093 cites W1508726918 @default.
- W4385995093 cites W151794463 @default.
- W4385995093 cites W1521439356 @default.
- W4385995093 cites W1553328291 @default.
- W4385995093 cites W1791199433 @default.
- W4385995093 cites W1895664041 @default.
- W4385995093 cites W1940436875 @default.
- W4385995093 cites W195113900 @default.
- W4385995093 cites W1964100897 @default.
- W4385995093 cites W1965665343 @default.
- W4385995093 cites W1967200224 @default.
- W4385995093 cites W1967472830 @default.
- W4385995093 cites W1969450955 @default.
- W4385995093 cites W1970094644 @default.
- W4385995093 cites W1971090593 @default.
- W4385995093 cites W1971813656 @default.
- W4385995093 cites W1972063333 @default.
- W4385995093 cites W1974909188 @default.
- W4385995093 cites W1975098194 @default.
- W4385995093 cites W1976735315 @default.
- W4385995093 cites W1979834447 @default.
- W4385995093 cites W1981356078 @default.
- W4385995093 cites W1981622392 @default.
- W4385995093 cites W1982025393 @default.
- W4385995093 cites W1983634320 @default.
- W4385995093 cites W1986803075 @default.
- W4385995093 cites W1987096917 @default.
- W4385995093 cites W1989786656 @default.
- W4385995093 cites W1994059959 @default.
- W4385995093 cites W1996093689 @default.
- W4385995093 cites W2001287774 @default.
- W4385995093 cites W2006846157 @default.
- W4385995093 cites W2009087480 @default.
- W4385995093 cites W2010937047 @default.
- W4385995093 cites W2012887148 @default.
- W4385995093 cites W2014209773 @default.
- W4385995093 cites W2014465991 @default.
- W4385995093 cites W2016247525 @default.
- W4385995093 cites W2018627808 @default.
- W4385995093 cites W2022061456 @default.
- W4385995093 cites W2022475418 @default.
- W4385995093 cites W2023592752 @default.
- W4385995093 cites W2024054297 @default.
- W4385995093 cites W2028451690 @default.
- W4385995093 cites W2032960277 @default.
- W4385995093 cites W2033753813 @default.
- W4385995093 cites W2036720621 @default.
- W4385995093 cites W2037128300 @default.
- W4385995093 cites W2038595737 @default.
- W4385995093 cites W2042490539 @default.
- W4385995093 cites W2047361789 @default.
- W4385995093 cites W2049369080 @default.
- W4385995093 cites W2050280746 @default.
- W4385995093 cites W2053243844 @default.
- W4385995093 cites W2055115911 @default.
- W4385995093 cites W2055987225 @default.
- W4385995093 cites W2065731270 @default.
- W4385995093 cites W2067006131 @default.
- W4385995093 cites W2067490994 @default.
- W4385995093 cites W2070522638 @default.
- W4385995093 cites W2073214088 @default.
- W4385995093 cites W2073970182 @default.
- W4385995093 cites W2075922566 @default.
- W4385995093 cites W2076506953 @default.
- W4385995093 cites W2078048204 @default.
- W4385995093 cites W2080917061 @default.
- W4385995093 cites W2082282629 @default.
- W4385995093 cites W2086588624 @default.
- W4385995093 cites W2095307942 @default.
- W4385995093 cites W2099167252 @default.
- W4385995093 cites W2106945775 @default.
- W4385995093 cites W2111370164 @default.
- W4385995093 cites W2114443210 @default.
- W4385995093 cites W2122746613 @default.
- W4385995093 cites W2124558372 @default.
- W4385995093 cites W2129152698 @default.
- W4385995093 cites W2130394891 @default.
- W4385995093 cites W2135749989 @default.