FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385996839> ?p ?o ?g. }

• W4385996839 endingPage "61" @default.
• W4385996839 startingPage "61" @default.
• W4385996839 abstract "Objective: Merkel cell carcinoma is an aggressive neuroendocrine skin cancer with a low incidence rate and higher local-regional and distant spread rates compared to other cutaneous carcinomas. The primary mass is excised with a safety margin of 10–20 mm and sentinel lymph node (SLN) sampling is performed, followed by adjuvant radiotherapy to the primary site. We aimed to determine the rate of Merkel cell carcinoma in the Eastern Black Sea Region and evaluate the effects of adjuvant radiotherapy after surgery on the development of local and distant metastases and survival. Materials and Methods: Forty-four patients with Merkel cell carcinoma who received adjuvant radiotherapy between 1996 and 2022 were analyzed retrospectively. Results: Forty-four patients were included in the study. Of these, 28 (64%) were male patients and 16 (36%) were female patients. The mean patient age was 78.2 ± 9.2 (age range: 49–97). The mean age of men was 76.35 ± 11.87 (range: 49–93) years, and of women was 80.3 ± 9.45 (range: 58–97) years. After a wide local excision with a 1–2 cm margin and SLN biopsy, adjuvant radiation therapy (RT) was applied to the primary site and regional lymph nodes (LNs). The primary site of the tumor was located in the head and neck in 27 (61%) patients; nose in four (10%) patients; forehead in two (4%) patients; neck in four (4%) patients; scalp in 19 (43%) patients; extremities in 13 (29%) patients, upper extremity in 11 (25% of patients), lower extremity in two (4%) patients, and trunk in four (10%) patients. When the patients are classified according to the stage, 23 (52%) were T1, 15 (34%) were T2, two (5%) were T3, and four (9%) were T4. There was no LN involvement in 29 (66%) patients. N1 was present in 11 (25%) patients and N2 was present in four (9%) patients. Eighteen (41%) of the patients were stage I, 11 (25%) were stage II, and 15 (34%) were stage III. In patients with negative surgical margins on the tumor bed, 56 Gy RT was delivered to the primary tumor site nose and forehead, and 60 Gy to other sites. 60 Gy RT was delivered in surgical margin-positive disease and 66 Gy in gross disease. Elective 50 Gy RT was delivered to regional LNs and 60 Gy RT was delivered to positive lymph node. RT doses were administered at 2 Gy/fraction daily. The 3-year loco-regional control rate was 71% (95% CI 52.8%–79.9%), and the 3-year survival rate was 73% (95% CI 65.5%–95.7%). LN positivity in univariate analysis was a significant predictor of loco-regional control. Conclusions: Although loco-regional spread in Merkel cell carcinoma can be controlled with LN surgery and adjuvant radiotherapy, the risk of distant metastasis and disease-related death is high." @default.
• W4385996839 created "2023-08-20" @default.
• W4385996839 creator A5034734313 @default.
• W4385996839 creator A5044580864 @default.
• W4385996839 creator A5092274525 @default.
• W4385996839 date "2022-01-01" @default.
• W4385996839 modified "2023-10-14" @default.
• W4385996839 title "Merkel cell carcinoma adjuvant radiotherapy: A single institution experience from the Northeast" @default.
• W4385996839 doi "https://doi.org/10.4103/bjoc.bjoc_13_23" @default.
• W4385996839 hasPublicationYear "2022" @default.
• W4385996839 type Work @default.
• W4385996839 citedByCount "0" @default.
• W4385996839 crossrefType "journal-article" @default.
• W4385996839 hasAuthorship W4385996839A5034734313 @default.
• W4385996839 hasAuthorship W4385996839A5044580864 @default.
• W4385996839 hasAuthorship W4385996839A5092274525 @default.
• W4385996839 hasConcept C121608353 @default.
• W4385996839 hasConcept C126322002 @default.
• W4385996839 hasConcept C126838900 @default.
• W4385996839 hasConcept C141071460 @default.
• W4385996839 hasConcept C2775934546 @default.
• W4385996839 hasConcept C2777546739 @default.
• W4385996839 hasConcept C2778342957 @default.
• W4385996839 hasConcept C2780212769 @default.
• W4385996839 hasConcept C2780291066 @default.
• W4385996839 hasConcept C2780849966 @default.
• W4385996839 hasConcept C509974204 @default.
• W4385996839 hasConcept C530470458 @default.
• W4385996839 hasConcept C71924100 @default.
• W4385996839 hasConceptScore W4385996839C121608353 @default.
• W4385996839 hasConceptScore W4385996839C126322002 @default.
• W4385996839 hasConceptScore W4385996839C126838900 @default.
• W4385996839 hasConceptScore W4385996839C141071460 @default.
• W4385996839 hasConceptScore W4385996839C2775934546 @default.
• W4385996839 hasConceptScore W4385996839C2777546739 @default.
• W4385996839 hasConceptScore W4385996839C2778342957 @default.
• W4385996839 hasConceptScore W4385996839C2780212769 @default.
• W4385996839 hasConceptScore W4385996839C2780291066 @default.
• W4385996839 hasConceptScore W4385996839C2780849966 @default.
• W4385996839 hasConceptScore W4385996839C509974204 @default.
• W4385996839 hasConceptScore W4385996839C530470458 @default.
• W4385996839 hasConceptScore W4385996839C71924100 @default.
• W4385996839 hasIssue "2" @default.
• W4385996839 hasLocation W43859968391 @default.
• W4385996839 hasOpenAccess W4385996839 @default.
• W4385996839 hasPrimaryLocation W43859968391 @default.
• W4385996839 hasRelatedWork W1972587384 @default.
• W4385996839 hasRelatedWork W1974359992 @default.
• W4385996839 hasRelatedWork W2009654336 @default.
• W4385996839 hasRelatedWork W2036151248 @default.
• W4385996839 hasRelatedWork W2070134296 @default.
• W4385996839 hasRelatedWork W2071728756 @default.
• W4385996839 hasRelatedWork W2117993001 @default.
• W4385996839 hasRelatedWork W2255285412 @default.
• W4385996839 hasRelatedWork W2327992135 @default.
• W4385996839 hasRelatedWork W55893804 @default.
• W4385996839 hasVolume "2" @default.
• W4385996839 isParatext "false" @default.
• W4385996839 isRetracted "false" @default.
• W4385996839 workType "article" @default.