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- W4385997251 abstract "Drug self-delivery systems (DSDSs) have been extensively exploited to enhance drug loading capacity and avoid excipient-related toxicity issues. However, deficient tumor targeting, inferior tumor permeability, prominent burst release, and nonspecific subcellular distribution remain major obstacles. Herein, we reported a ROS-responsive amphiphilic prodrug (CPT-S-NO) synthesized by the conjugation of zwitterionic tertiary amine-oxide (TAO) moiety and hydrophobic camptothecin (CPT) through a thioether linkage, which formed a nanoparticulate DSDS in an aqueous solution. CPT-S-NO, compared with CPT-11 and the water-soluble TAO-modified CPT prodrug (CPT-NO), exhibited prolonged blood circulation, enhanced tumor accumulation, deep tumor penetration, efficient mitochondrial targeting, and ROS-activated drug release to induce mitochondrial dysfunction, corporately conducing to the superior antitumor efficacy in vivo. This TAO decoration strategy promises potential applications in designing multipotent DSDSs for various drugs." @default.
- W4385997251 created "2023-08-20" @default.
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- W4385997251 date "2023-09-01" @default.
- W4385997251 modified "2023-10-14" @default.
- W4385997251 title "Tumor permeable self-delivery nanodrug targeting mitochondria for enhanced chemotherapy" @default.
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- W4385997251 doi "https://doi.org/10.1016/j.jconrel.2023.08.032" @default.
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