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- W4385998348 abstract "Summary Lymph node stromal cells (LNSCs) have a crucial immunomodulatory function, but their heterogeneity in human is incompletely understood. Here, we report the single cell RNA sequencing (scRNA-seq) of 12’000 LNSCs isolated from a human lymph node (LN). This study comprehensively defines the gene signatures of 10 fibroblast subtypes: CCL21 + SC, CCL19 + SC, CD34 + CXCL14 + SC, pericytes, DES + SC, LAMP5 + SC, NR4A1 + BCAM + SC, HLA-DR + SC, SEPT4 + SC and GLDN + SC. To explore the heterogeneous stromal compartment within the complex LN tissue architecture, we integrated the scRNA-seq profiles of the identified LNSC subsets with a publicly available human spatial transcriptomic LN dataset and predicted their location within the complex LN tissue architecture. Each LNSC subtype was spatially restricted to specific LN regions, indicating different LNSC-lymphocyte interactions which was further investigated using NicheNet. The positioning of distinct LNSC subtypes in different LN regions sets the stage for future research on the relationship between LNSC-specific niches and immunomodulatory function during health and disease." @default.
- W4385998348 created "2023-08-20" @default.
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- W4385998348 date "2023-08-19" @default.
- W4385998348 modified "2023-10-07" @default.
- W4385998348 title "Identification and mapping of human lymph node stromal cell subsets by combining single-cell RNA sequencing with spatial transcriptomics" @default.
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- W4385998348 doi "https://doi.org/10.1101/2023.08.18.553530" @default.
- W4385998348 hasPublicationYear "2023" @default.
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