FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385999377> ?p ?o ?g. }

• W4385999377 abstract "Abstract The ability to model physiological systems through 3D neural in-vitro systems may enable new treatments for various diseases while lowering the need for challenging animal and human testing. Creating such an environment, and even more impactful, one that mimics human brain tissue under mechanical stimulation, would be extremely useful to study a range of human-specific biological processes and conditions related to brain trauma. One approach is to use human cerebral organoids (hCOs) in-vitro models. hCOs recreate key cytoarchitectural features of the human brain, distinguishing themselves from more traditional 2D cultures and organ-on-a-chip models, as well as in-vivo animal models. Here, we propose a novel approach to emulate mild and moderate traumatic brain injury (TBI) using hCOs that undergo strain rates indicative of TBI. We subjected the hCOs to mild (2 s $$^{-1}$$ <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML> <mml:msup> <mml:mrow /> <mml:mrow> <mml:mo>-</mml:mo> <mml:mn>1</mml:mn> </mml:mrow> </mml:msup> </mml:math> ) and moderate (14 s $$^{-1}$$ <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML> <mml:msup> <mml:mrow /> <mml:mrow> <mml:mo>-</mml:mo> <mml:mn>1</mml:mn> </mml:mrow> </mml:msup> </mml:math> ) loading conditions, examined the mechanotransduction response, and investigated downstream genomic effects and regulatory pathways. The revealed pathways of note were cell death and metabolic and biosynthetic pathways implicating genes such as CARD9, ENO1, and FOXP3, respectively. Additionally, we show a steeper ascent in calcium signaling as we imposed higher loading conditions on the organoids. The elucidation of neural response to mechanical stimulation in reliable human cerebral organoid models gives insights into a better understanding of TBI in humans." @default.
• W4385999377 created "2023-08-20" @default.
• W4385999377 creator A5010238204 @default.
• W4385999377 creator A5018798028 @default.
• W4385999377 creator A5022390263 @default.
• W4385999377 creator A5032225706 @default.
• W4385999377 creator A5040443011 @default.
• W4385999377 creator A5059723823 @default.
• W4385999377 creator A5063233953 @default.
• W4385999377 creator A5071289116 @default.
• W4385999377 creator A5072374777 @default.
• W4385999377 date "2023-08-19" @default.
• W4385999377 modified "2023-10-12" @default.
• W4385999377 title "Characterization of neural mechanotransduction response in human traumatic brain injury organoid model" @default.
• W4385999377 cites W1567387204 @default.
• W4385999377 cites W1763750158 @default.
• W4385999377 cites W1768523798 @default.
• W4385999377 cites W1912466591 @default.
• W4385999377 cites W1968787932 @default.
• W4385999377 cites W1969929083 @default.
• W4385999377 cites W1970283678 @default.
• W4385999377 cites W1970761811 @default.
• W4385999377 cites W1997435185 @default.
• W4385999377 cites W1999349182 @default.
• W4385999377 cites W2000498157 @default.
• W4385999377 cites W2005556241 @default.
• W4385999377 cites W2018286352 @default.
• W4385999377 cites W2041360024 @default.
• W4385999377 cites W2046165140 @default.
• W4385999377 cites W2054084798 @default.
• W4385999377 cites W2054968721 @default.
• W4385999377 cites W2077024919 @default.
• W4385999377 cites W2078682315 @default.
• W4385999377 cites W2079063094 @default.
• W4385999377 cites W2085558085 @default.
• W4385999377 cites W2093281755 @default.
• W4385999377 cites W2094430543 @default.
• W4385999377 cites W2095616696 @default.
• W4385999377 cites W2098107049 @default.
• W4385999377 cites W2099180554 @default.
• W4385999377 cites W2116016048 @default.
• W4385999377 cites W2130407823 @default.
• W4385999377 cites W2141679195 @default.
• W4385999377 cites W2141770251 @default.
• W4385999377 cites W2142046013 @default.
• W4385999377 cites W2155971051 @default.
• W4385999377 cites W2167279371 @default.
• W4385999377 cites W2311770845 @default.
• W4385999377 cites W2398013797 @default.
• W4385999377 cites W2486492325 @default.
• W4385999377 cites W2580419078 @default.
• W4385999377 cites W2605342534 @default.
• W4385999377 cites W2607444689 @default.
• W4385999377 cites W2608826008 @default.
• W4385999377 cites W2725171488 @default.
• W4385999377 cites W2739301921 @default.
• W4385999377 cites W2742887011 @default.
• W4385999377 cites W2745113344 @default.
• W4385999377 cites W2753168648 @default.
• W4385999377 cites W2784363986 @default.
• W4385999377 cites W2787895993 @default.
• W4385999377 cites W2788640168 @default.
• W4385999377 cites W2790260761 @default.
• W4385999377 cites W2888450536 @default.
• W4385999377 cites W2922854104 @default.
• W4385999377 cites W2938233427 @default.
• W4385999377 cites W2943807517 @default.
• W4385999377 cites W2968708350 @default.
• W4385999377 cites W2990737501 @default.
• W4385999377 cites W3033526288 @default.
• W4385999377 cites W3034244015 @default.
• W4385999377 cites W3082286753 @default.
• W4385999377 cites W3092621787 @default.
• W4385999377 cites W3092792575 @default.
• W4385999377 cites W3124906624 @default.
• W4385999377 cites W3178067767 @default.
• W4385999377 cites W3183486118 @default.
• W4385999377 cites W3200728186 @default.
• W4385999377 cites W3204717718 @default.
• W4385999377 cites W3213424921 @default.
• W4385999377 cites W4200457339 @default.
• W4385999377 cites W4210698503 @default.
• W4385999377 cites W4220919515 @default.
• W4385999377 cites W4239225232 @default.
• W4385999377 cites W4253308936 @default.
• W4385999377 doi "https://doi.org/10.1038/s41598-023-40431-y" @default.
• W4385999377 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37598247" @default.
• W4385999377 hasPublicationYear "2023" @default.
• W4385999377 type Work @default.
• W4385999377 citedByCount "0" @default.
• W4385999377 crossrefType "journal-article" @default.
• W4385999377 hasAuthorship W4385999377A5010238204 @default.
• W4385999377 hasAuthorship W4385999377A5018798028 @default.
• W4385999377 hasAuthorship W4385999377A5022390263 @default.
• W4385999377 hasAuthorship W4385999377A5032225706 @default.
• W4385999377 hasAuthorship W4385999377A5040443011 @default.
• W4385999377 hasAuthorship W4385999377A5059723823 @default.
• W4385999377 hasAuthorship W4385999377A5063233953 @default.
• W4385999377 hasAuthorship W4385999377A5071289116 @default.
• W4385999377 hasAuthorship W4385999377A5072374777 @default.

• next