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- W4386001050 abstract "The increasing prevalence of antibiotic-resistant bacterial infections, particularly methicillin-resistant Staphylococcus aureus (MRSA), presents a significant public health concern. Timely detection of MRSA is crucial to enable prompt medical intervention, limit its spread, and reduce antimicrobial resistance. Here, we introduce a miniaturized nano-sieve device featuring a pneumatically-regulated chamber for highly efficient MRSA purification from human plasma samples. By using packed magnetic beads as a filter and leveraging the deformability of the nano-sieve channel, we achieve an on-chip concentration factor of 15 for MRSA. We integrated this device with recombinase polymerase amplification (RPA) and clustered regularly interspaced short palindromic repeats (CRISPR)-Cas detection system, resulting in an on-chip limit of detection (LOD) of approximately 100 CFU/mL. This developed approach provides a rapid, precise, and centrifuge-free solution suitable for point-of-care diagnostics, with the potential to significantly improve patient outcomes in resource-limited medical conditions." @default.
- W4386001050 created "2023-08-20" @default.
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- W4386001050 date "2023-08-18" @default.
- W4386001050 modified "2023-10-07" @default.
- W4386001050 title "Pneumatic Nano-Sieve for CRISPR-based Detection of Drug-resistant Bacteria" @default.
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- W4386001050 doi "https://doi.org/10.1101/2023.08.17.553737" @default.
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