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- W4386001310 abstract "Ovarian cancer is a leading cause of death in females with gynecologic cancers. Pyroptosis is a relatively new discovered programmed cell death that is believed to be associated with inflammation. However, studies on pyroptosis-related lncRNAs in ovarian cancer are limited. In this study, we identified 29 pyroptosis-related genes and screened out 72 pyroptosis-related lncRNAs. Furthermore, the 72 lncRNAs were eliminated to 2 survival-related lncRNAs using Cox regression and Lasso regression to build an ovarian cancer prognostic prediction signature and were further validated on the test set. We adopted a riskscore from the two-gene signature, and the survival in low-risk group was higher than the high-risk group. Functional enrichment analysis indicated that the differentially expressed genes (DEGs) between two risk groups were associated with tumor immunity. This study implies that pyroptosis-related genes are closely related to tumor immunity and could be potential therapeutic factors for ovarian cancer treatment." @default.
- W4386001310 created "2023-08-20" @default.
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- W4386001310 date "2023-08-19" @default.
- W4386001310 modified "2023-09-26" @default.
- W4386001310 title "The role of pyroptosis-related lncRNA risk signature in ovarian cancer prognosis and immune system" @default.
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- W4386001310 doi "https://doi.org/10.1007/s12672-023-00767-3" @default.
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