FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386001394> ?p ?o ?g. }

• W4386001394 abstract "Autophagy is a lysosome-dependent bulk degradation process essential for cell viability but excessive autophagy leads to a unique form of cell death termed autosis. Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer with notable defect in its autophagy process. In previous studies, we developed stapled peptides that specifically targeted the essential autophagy protein Beclin 1 to induce autophagy and promote endolysosomal trafficking. Here we show that one lead peptide Tat-SP4 induced mild increase of autophagy in TNBC cells but showed potent anti-proliferative effect that could not be rescued by inhibitors of programmed cell death pathways. The cell death induced by Tat-SP4 showed typical features of autosis including sustained adherence to the substrate surface, rupture of plasma membrane and effective rescue by digoxin, a cardioglycoside that blocks the Na+/K+ ATPase. Tat-SP4 also induced prominent mitochondria dysfunction including loss of mitochondria membrane potential, elevated mitochondria reactive oxygen species and reduced oxidative phosphorylation. The anti-proliferative effect of Tat-SP4 was confirmed in a TNBC xenograft model. Our study uncovers three notable aspects of autosis. Firstly, autosis can be triggered by moderate increase in autophagy if such increase exceeds the endogenous capacity of the host cells. Secondly, mitochondria may play an essential role in autosis with dysregulated autophagy leading to mitochondria dysfunction to trigger autosis. Lastly, intrinsic autophagy deficiency and quiescent mitochondria bioenergetic profile likely render TNBC cells particularly susceptible to autosis. Our designed peptides like Tat-SP4 may serve as potential therapeutic candidates against TNBC by targeting this vulnerability." @default.
• W4386001394 created "2023-08-20" @default.
• W4386001394 creator A5002465763 @default.
• W4386001394 creator A5007204095 @default.
• W4386001394 creator A5013958305 @default.
• W4386001394 creator A5015551610 @default.
• W4386001394 creator A5017270204 @default.
• W4386001394 creator A5017424505 @default.
• W4386001394 creator A5033955713 @default.
• W4386001394 creator A5036163281 @default.
• W4386001394 creator A5068161054 @default.
• W4386001394 creator A5088533080 @default.
• W4386001394 date "2023-08-19" @default.
• W4386001394 modified "2023-10-09" @default.
• W4386001394 title "An autophagy-inducing stapled peptide induces mitochondria dysfunction and triggers autotic cell death in triple-negative breast cancer" @default.
• W4386001394 cites W1523693806 @default.
• W4386001394 cites W1562982734 @default.
• W4386001394 cites W1741052239 @default.
• W4386001394 cites W1784425676 @default.
• W4386001394 cites W1945617445 @default.
• W4386001394 cites W1975915706 @default.
• W4386001394 cites W2003380425 @default.
• W4386001394 cites W2020112232 @default.
• W4386001394 cites W2034339677 @default.
• W4386001394 cites W2045122835 @default.
• W4386001394 cites W2048030072 @default.
• W4386001394 cites W2054580728 @default.
• W4386001394 cites W2055811314 @default.
• W4386001394 cites W2064746187 @default.
• W4386001394 cites W2066800765 @default.
• W4386001394 cites W2090038499 @default.
• W4386001394 cites W2096027508 @default.
• W4386001394 cites W2109034822 @default.
• W4386001394 cites W2119215169 @default.
• W4386001394 cites W2134539328 @default.
• W4386001394 cites W2145084709 @default.
• W4386001394 cites W2159937179 @default.
• W4386001394 cites W2161594732 @default.
• W4386001394 cites W2402636472 @default.
• W4386001394 cites W2430731787 @default.
• W4386001394 cites W2560836545 @default.
• W4386001394 cites W2621271973 @default.
• W4386001394 cites W2788640168 @default.
• W4386001394 cites W2807638532 @default.
• W4386001394 cites W2886477543 @default.
• W4386001394 cites W2889608418 @default.
• W4386001394 cites W2897422388 @default.
• W4386001394 cites W2905399276 @default.
• W4386001394 cites W2909477364 @default.
• W4386001394 cites W2917403028 @default.
• W4386001394 cites W2946922275 @default.
• W4386001394 cites W2980622391 @default.
• W4386001394 cites W3000546975 @default.
• W4386001394 cites W3033869790 @default.
• W4386001394 cites W3045893613 @default.
• W4386001394 cites W3080827788 @default.
• W4386001394 cites W3092966039 @default.
• W4386001394 cites W3156641770 @default.
• W4386001394 cites W3156985612 @default.
• W4386001394 cites W3170283419 @default.
• W4386001394 cites W3196618302 @default.
• W4386001394 cites W3214677673 @default.
• W4386001394 cites W4210491356 @default.
• W4386001394 cites W4213217796 @default.
• W4386001394 cites W4229079181 @default.
• W4386001394 cites W4285992810 @default.
• W4386001394 cites W4293044445 @default.
• W4386001394 cites W4306641716 @default.
• W4386001394 doi "https://doi.org/10.1038/s41420-023-01600-0" @default.
• W4386001394 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37598181" @default.
• W4386001394 hasPublicationYear "2023" @default.
• W4386001394 type Work @default.
• W4386001394 citedByCount "0" @default.
• W4386001394 crossrefType "journal-article" @default.
• W4386001394 hasAuthorship W4386001394A5002465763 @default.
• W4386001394 hasAuthorship W4386001394A5007204095 @default.
• W4386001394 hasAuthorship W4386001394A5013958305 @default.
• W4386001394 hasAuthorship W4386001394A5015551610 @default.
• W4386001394 hasAuthorship W4386001394A5017270204 @default.
• W4386001394 hasAuthorship W4386001394A5017424505 @default.
• W4386001394 hasAuthorship W4386001394A5033955713 @default.
• W4386001394 hasAuthorship W4386001394A5036163281 @default.
• W4386001394 hasAuthorship W4386001394A5068161054 @default.
• W4386001394 hasAuthorship W4386001394A5088533080 @default.
• W4386001394 hasBestOaLocation W43860013941 @default.
• W4386001394 hasConcept C121608353 @default.
• W4386001394 hasConcept C1491633281 @default.
• W4386001394 hasConcept C181199279 @default.
• W4386001394 hasConcept C185592680 @default.
• W4386001394 hasConcept C190283241 @default.
• W4386001394 hasConcept C203522944 @default.
• W4386001394 hasConcept C2780110267 @default.
• W4386001394 hasConcept C2780216420 @default.
• W4386001394 hasConcept C28859421 @default.
• W4386001394 hasConcept C31573885 @default.
• W4386001394 hasConcept C502942594 @default.
• W4386001394 hasConcept C530470458 @default.
• W4386001394 hasConcept C54355233 @default.
• W4386001394 hasConcept C55493867 @default.
• W4386001394 hasConcept C86803240 @default.

• next