Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386001456> ?p ?o ?g. }
- W4386001456 abstract "Bacterial RNA helicase ρ is a genome sentinel that terminates synthesis of damaged and junk RNAs that are not translated by the ribosome. Co-transcriptional RNA surveillance by ρ is essential for quality control of the transcriptome during optimal growth. However, it is unclear how bacteria protect their RNAs from overzealous ρ during dormancy or stress, conditions common in natural habitats. Here we used cryogenic electron microscopy, biochemical, and genetic approaches to show that residue substitutions, ADP, or ppGpp promote hyper-oligomerization of Escherichia coli ρ. Our results demonstrate that nucleotides bound at subunit interfaces control ρ switching from active hexamers to inactive higher-order oligomers and extended filaments. Polymers formed upon exposure to antibiotics or ppGpp disassemble when stress is relieved, thereby directly linking termination activity to cellular physiology. Inactivation of ρ through hyper-oligomerization is a regulatory strategy shared by RNA polymerases, ribosomes, and metabolic enzymes across all life." @default.
- W4386001456 created "2023-08-20" @default.
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- W4386001456 date "2023-08-18" @default.
- W4386001456 modified "2023-10-12" @default.
- W4386001456 title "Transcription termination factor ρ polymerizes under stress" @default.
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- W4386001456 doi "https://doi.org/10.1101/2023.08.18.553922" @default.
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