Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386001574> ?p ?o ?g. }
- W4386001574 abstract "Abstract Purines are required for fundamental biological processes and alterations in their metabolism lead to severe genetic diseases associated with developmental defects whose etiology remains unclear. Here, we studied the developmental requirements for purine metabolism using the amphibian Xenopus laevis as a vertebrate model. We provide the first functional characterization of purine pathway-genes and show that these genes are mostly expressed in nervous and muscular embryonic tissues. Morphants were generated to decipher the functions of these genes, with a focus on the adenylosuccinate lyase ( ADSL ), an enzyme required for both salvage and de novo purine pathways. adsl.L knock-down leads to severe reduction in the expression of the Myogenic Regulatory Factors (MRFs: Myod1, Myf5 and Myogenin), thus resulting in defects in somitogenesis and in the formation and/or migration of both craniofacial and hypaxial muscle progenitors. Similar alterations were observed upon reduced expression of hprt1.L and ppat , two genes specific to the salvage and the de novo pathways, respectively. In conclusion, our data shows for the first time that de novo and recycling purine pathways are essential for myogenesis and highlight new mechanisms in the regulation of MRFs gene expression." @default.
- W4386001574 created "2023-08-20" @default.
- W4386001574 creator A5008557150 @default.
- W4386001574 creator A5052985728 @default.
- W4386001574 creator A5082543844 @default.
- W4386001574 creator A5083142515 @default.
- W4386001574 creator A5083989677 @default.
- W4386001574 creator A5088388229 @default.
- W4386001574 creator A5092665438 @default.
- W4386001574 date "2023-08-18" @default.
- W4386001574 modified "2023-10-07" @default.
- W4386001574 title "Purine biosynthesis pathways are required for myogenesis in<i>Xenopus laevis</i>" @default.
- W4386001574 cites W1502229532 @default.
- W4386001574 cites W1731477248 @default.
- W4386001574 cites W1964062070 @default.
- W4386001574 cites W1967080927 @default.
- W4386001574 cites W1975248908 @default.
- W4386001574 cites W1976790675 @default.
- W4386001574 cites W1980515463 @default.
- W4386001574 cites W1993663956 @default.
- W4386001574 cites W1995679486 @default.
- W4386001574 cites W1996646041 @default.
- W4386001574 cites W1996783999 @default.
- W4386001574 cites W1997335051 @default.
- W4386001574 cites W1997338257 @default.
- W4386001574 cites W1997866922 @default.
- W4386001574 cites W2000120778 @default.
- W4386001574 cites W2006334642 @default.
- W4386001574 cites W2019301090 @default.
- W4386001574 cites W2028690554 @default.
- W4386001574 cites W2041709728 @default.
- W4386001574 cites W2047871248 @default.
- W4386001574 cites W2052851218 @default.
- W4386001574 cites W2053127406 @default.
- W4386001574 cites W2057329733 @default.
- W4386001574 cites W2059224185 @default.
- W4386001574 cites W2062589976 @default.
- W4386001574 cites W2065752482 @default.
- W4386001574 cites W2070849951 @default.
- W4386001574 cites W2078388909 @default.
- W4386001574 cites W2086127877 @default.
- W4386001574 cites W2093569973 @default.
- W4386001574 cites W2097831093 @default.
- W4386001574 cites W2101221992 @default.
- W4386001574 cites W2102629679 @default.
- W4386001574 cites W2114313367 @default.
- W4386001574 cites W2114329214 @default.
- W4386001574 cites W2114706604 @default.
- W4386001574 cites W2165034468 @default.
- W4386001574 cites W2168615373 @default.
- W4386001574 cites W2168974900 @default.
- W4386001574 cites W2172087298 @default.
- W4386001574 cites W2304525120 @default.
- W4386001574 cites W2331564618 @default.
- W4386001574 cites W2416745586 @default.
- W4386001574 cites W2534919910 @default.
- W4386001574 cites W2575518983 @default.
- W4386001574 cites W2606144196 @default.
- W4386001574 cites W2611350333 @default.
- W4386001574 cites W27486670 @default.
- W4386001574 cites W2887491890 @default.
- W4386001574 cites W2911127775 @default.
- W4386001574 cites W2914112166 @default.
- W4386001574 cites W2959102449 @default.
- W4386001574 cites W2972208562 @default.
- W4386001574 cites W3015110479 @default.
- W4386001574 cites W3135758045 @default.
- W4386001574 cites W4206290831 @default.
- W4386001574 cites W4220761293 @default.
- W4386001574 cites W4235166814 @default.
- W4386001574 cites W4285585594 @default.
- W4386001574 doi "https://doi.org/10.1101/2023.08.17.553788" @default.
- W4386001574 hasPublicationYear "2023" @default.
- W4386001574 type Work @default.
- W4386001574 citedByCount "0" @default.
- W4386001574 crossrefType "posted-content" @default.
- W4386001574 hasAuthorship W4386001574A5008557150 @default.
- W4386001574 hasAuthorship W4386001574A5052985728 @default.
- W4386001574 hasAuthorship W4386001574A5082543844 @default.
- W4386001574 hasAuthorship W4386001574A5083142515 @default.
- W4386001574 hasAuthorship W4386001574A5083989677 @default.
- W4386001574 hasAuthorship W4386001574A5088388229 @default.
- W4386001574 hasAuthorship W4386001574A5092665438 @default.
- W4386001574 hasBestOaLocation W43860015741 @default.
- W4386001574 hasConcept C104317684 @default.
- W4386001574 hasConcept C169586020 @default.
- W4386001574 hasConcept C181199279 @default.
- W4386001574 hasConcept C194101687 @default.
- W4386001574 hasConcept C207200792 @default.
- W4386001574 hasConcept C2776476023 @default.
- W4386001574 hasConcept C2778463287 @default.
- W4386001574 hasConcept C2779535977 @default.
- W4386001574 hasConcept C3763915 @default.
- W4386001574 hasConcept C512185932 @default.
- W4386001574 hasConcept C55493867 @default.
- W4386001574 hasConcept C86803240 @default.
- W4386001574 hasConcept C95444343 @default.
- W4386001574 hasConcept C97816823 @default.
- W4386001574 hasConceptScore W4386001574C104317684 @default.
- W4386001574 hasConceptScore W4386001574C169586020 @default.