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- W4386001588 abstract "Acoustic coupling through hairs remains a challenge to performing transcranial-focused ultrasound procedures. Here, we demonstrated that this challenge could be addressed by using oil as the coupling medium, leveraging oil's high affinity to hairs due to their inherent hydrophobicity. We compared focused ultrasound-induced blood-brain barrier opening (FUS-BBBO) outcomes in mice under three coupling conditions: oil with hairs (oil + hairs), ultrasound gel with hair shaving (ultrasound gel + no hair), and ultrasound gel with hairs (ultrasound gel + hairs). The quality of the coupling was evaluated by [Formula: see text]-weighted magnetic resonance imaging (MRI) and passive cavitation detection (PCD). The outcome of FUS-BBBO was assessed by MRI contrast agent extravasation using in vivo [Formula: see text]-weighted contrast-enhanced MRI. It was also evaluated by ex vivo fluorescence imaging of the mouse brain after intravenous injection of a model drug, Evans blue. The results showed that oil + hairs consistently achieved high-quality acoustic coupling without trapping air bubbles. The FUS-BBBO outcome was not significantly different between the oil + hairs and the ultrasound gel + no hair groups. These two groups had significantly higher levels of BBB opening than the ultrasound gel + hairs group. This study demonstrated that oil could be a coupling medium for transcranial FUS procedures without shaving hairs." @default.
- W4386001588 created "2023-08-20" @default.
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- W4386001588 date "2023-08-19" @default.
- W4386001588 modified "2023-10-13" @default.
- W4386001588 title "Transcranial focused ultrasound-induced blood‒brain barrier opening in mice without shaving hairs" @default.
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- W4386001588 doi "https://doi.org/10.1038/s41598-023-40598-4" @default.
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