Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386001919> ?p ?o ?g. }
- W4386001919 abstract "Abstract Histone deacetylases are important epigenetic regulators that have been reported to play essential roles in cancer stem cell functions and are promising therapeutic targets in many cancers including glioblastoma. However, the functionally relevant roles of specific histone deacetylases, in the maintenance of key self-renewal and growth characteristics of brain tumour stem cell (BTSC) sub-populations of glioblastoma, remain to be fully resolved. Here, using pharmacological inhibition and genetic loss and gain of function approaches, we identify HDAC2 as the most relevant histone deacetylase for re-organization of chromatin accessibility resulting in maintenance of BTSC growth and self-renewal properties. Furthermore, its specific interaction with the transforming growth factor-β pathway related proteins, SMAD3 and SKI, is crucial for the maintenance of tumorigenic potential in BTSCs in vitro and in orthotopic xenograft models. Inhibition of HDAC2 activity and disruption of the coordinated mechanisms regulated by the HDAC2-SMAD3-SKI axis are thus promising therapeutic approaches for targeting BTSCs." @default.
- W4386001919 created "2023-08-20" @default.
- W4386001919 creator A5015185322 @default.
- W4386001919 creator A5028077305 @default.
- W4386001919 creator A5029520197 @default.
- W4386001919 creator A5058427382 @default.
- W4386001919 creator A5069571795 @default.
- W4386001919 creator A5089038043 @default.
- W4386001919 creator A5089538136 @default.
- W4386001919 date "2023-08-19" @default.
- W4386001919 modified "2023-10-12" @default.
- W4386001919 title "Epigenetic and molecular coordination between HDAC2 and SMAD3-SKI regulates essential brain tumour stem cell characteristics" @default.
- W4386001919 cites W1540671324 @default.
- W4386001919 cites W1890699937 @default.
- W4386001919 cites W1951559178 @default.
- W4386001919 cites W1951630905 @default.
- W4386001919 cites W1964233786 @default.
- W4386001919 cites W1969386224 @default.
- W4386001919 cites W1984173288 @default.
- W4386001919 cites W2001544973 @default.
- W4386001919 cites W2012069537 @default.
- W4386001919 cites W2014051729 @default.
- W4386001919 cites W2014677321 @default.
- W4386001919 cites W2025183726 @default.
- W4386001919 cites W2036044314 @default.
- W4386001919 cites W2036870885 @default.
- W4386001919 cites W2041415274 @default.
- W4386001919 cites W2047098628 @default.
- W4386001919 cites W2055988323 @default.
- W4386001919 cites W2065556782 @default.
- W4386001919 cites W2078510083 @default.
- W4386001919 cites W2086711528 @default.
- W4386001919 cites W2090760765 @default.
- W4386001919 cites W2103441770 @default.
- W4386001919 cites W2110949408 @default.
- W4386001919 cites W2114265914 @default.
- W4386001919 cites W2115593774 @default.
- W4386001919 cites W2124078079 @default.
- W4386001919 cites W2124556650 @default.
- W4386001919 cites W2131271579 @default.
- W4386001919 cites W2135656436 @default.
- W4386001919 cites W2135925682 @default.
- W4386001919 cites W2136121675 @default.
- W4386001919 cites W2154618092 @default.
- W4386001919 cites W2156534427 @default.
- W4386001919 cites W2156636883 @default.
- W4386001919 cites W2167650288 @default.
- W4386001919 cites W2171808845 @default.
- W4386001919 cites W2179638825 @default.
- W4386001919 cites W2201057556 @default.
- W4386001919 cites W2252865158 @default.
- W4386001919 cites W2281977757 @default.
- W4386001919 cites W2283600846 @default.
- W4386001919 cites W2340087533 @default.
- W4386001919 cites W2527902762 @default.
- W4386001919 cites W2560072559 @default.
- W4386001919 cites W2561012755 @default.
- W4386001919 cites W2604997718 @default.
- W4386001919 cites W2614766647 @default.
- W4386001919 cites W2617506851 @default.
- W4386001919 cites W2774477342 @default.
- W4386001919 cites W2779276028 @default.
- W4386001919 cites W2792755870 @default.
- W4386001919 cites W2797319688 @default.
- W4386001919 cites W2805654943 @default.
- W4386001919 cites W2892763111 @default.
- W4386001919 cites W2895954009 @default.
- W4386001919 cites W2898545092 @default.
- W4386001919 cites W2912602884 @default.
- W4386001919 cites W2938307111 @default.
- W4386001919 cites W2971157179 @default.
- W4386001919 cites W2984708337 @default.
- W4386001919 cites W3040737854 @default.
- W4386001919 cites W3076991851 @default.
- W4386001919 cites W3197017270 @default.
- W4386001919 cites W3203080334 @default.
- W4386001919 cites W4294968846 @default.
- W4386001919 cites W574602253 @default.
- W4386001919 doi "https://doi.org/10.1038/s41467-023-40776-y" @default.
- W4386001919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37598220" @default.
- W4386001919 hasPublicationYear "2023" @default.
- W4386001919 type Work @default.
- W4386001919 citedByCount "0" @default.
- W4386001919 crossrefType "journal-article" @default.
- W4386001919 hasAuthorship W4386001919A5015185322 @default.
- W4386001919 hasAuthorship W4386001919A5028077305 @default.
- W4386001919 hasAuthorship W4386001919A5029520197 @default.
- W4386001919 hasAuthorship W4386001919A5058427382 @default.
- W4386001919 hasAuthorship W4386001919A5069571795 @default.
- W4386001919 hasAuthorship W4386001919A5089038043 @default.
- W4386001919 hasAuthorship W4386001919A5089538136 @default.
- W4386001919 hasBestOaLocation W43860019191 @default.
- W4386001919 hasConcept C104317684 @default.
- W4386001919 hasConcept C167227067 @default.
- W4386001919 hasConcept C2778305200 @default.
- W4386001919 hasConcept C28328180 @default.
- W4386001919 hasConcept C41091548 @default.
- W4386001919 hasConcept C502942594 @default.
- W4386001919 hasConcept C54355233 @default.
- W4386001919 hasConcept C552990157 @default.